Doramectin efficacy against Psoroptes ovis in sheep: Evaluation of pharmacological strategies
The aims of this study were to evaluate the efficacy of two injectable formulations of doramectin (DRM) against Psoroptes ovis in sheep infested under controlled experimental conditions and to characterize the DRM plasma disposition kinetics in the infested animals. To this end, sheep were experimen...
| Autores principales: | , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/8088 https://www.sciencedirect.com/science/article/abs/pii/S001448942030196X https://doi.org/10.1016/j.exppara.2020.107998 |
| _version_ | 1855484132103028736 |
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| author | Larroza, Marcela Patricia Soler, Paula Robles, Carlos Alejandro Cabrera, Francisco Raúl Ballent, Mariana Lanusse, Carlos Lifschitz, Adrian Luis |
| author_browse | Ballent, Mariana Cabrera, Francisco Raúl Lanusse, Carlos Larroza, Marcela Patricia Lifschitz, Adrian Luis Robles, Carlos Alejandro Soler, Paula |
| author_facet | Larroza, Marcela Patricia Soler, Paula Robles, Carlos Alejandro Cabrera, Francisco Raúl Ballent, Mariana Lanusse, Carlos Lifschitz, Adrian Luis |
| author_sort | Larroza, Marcela Patricia |
| collection | INTA Digital |
| description | The aims of this study were to evaluate the efficacy of two injectable formulations of doramectin (DRM) against Psoroptes ovis in sheep infested under controlled experimental conditions and to characterize the DRM plasma disposition kinetics in the infested animals. To this end, sheep were experimentally infested with a P. ovis strain from a farm with a history of treatment failure, and then treated either with DRM 1% (traditional preparation) on days 0 and 7 or with DRM 3.15% (long-acting formulation) on day 0. The efficacy of each treatment was calculated by counting live mites in skin scrapings. Plasma samples were obtained from each animal and DRM concentrations were measured by HPLC. After the two doses of DRM 1%, the maximum efficacy (98.8%) was reached on day 28, whereas after the single dose of DRM 3.15%, the maximum efficacy (100%) was reached on day 35 and ratified on day 42. The longacting formulation allowed obtaining higher exposure and more sustained concentrations of DRM than the traditional preparation. Although both DRM formulations studied were effective according to international protocols, they did not reach 100% effectiveness in the time required for approved pharmaceutical products against sheep scab, according to Argentine regulations. |
| format | Artículo |
| id | INTA8088 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA80882022-11-04T14:21:19Z Doramectin efficacy against Psoroptes ovis in sheep: Evaluation of pharmacological strategies Larroza, Marcela Patricia Soler, Paula Robles, Carlos Alejandro Cabrera, Francisco Raúl Ballent, Mariana Lanusse, Carlos Lifschitz, Adrian Luis Psoroptes Ovis Enfermedades de los Animales Control de Enfermedades Animal Diseases Disease Control DRM The aims of this study were to evaluate the efficacy of two injectable formulations of doramectin (DRM) against Psoroptes ovis in sheep infested under controlled experimental conditions and to characterize the DRM plasma disposition kinetics in the infested animals. To this end, sheep were experimentally infested with a P. ovis strain from a farm with a history of treatment failure, and then treated either with DRM 1% (traditional preparation) on days 0 and 7 or with DRM 3.15% (long-acting formulation) on day 0. The efficacy of each treatment was calculated by counting live mites in skin scrapings. Plasma samples were obtained from each animal and DRM concentrations were measured by HPLC. After the two doses of DRM 1%, the maximum efficacy (98.8%) was reached on day 28, whereas after the single dose of DRM 3.15%, the maximum efficacy (100%) was reached on day 35 and ratified on day 42. The longacting formulation allowed obtaining higher exposure and more sustained concentrations of DRM than the traditional preparation. Although both DRM formulations studied were effective according to international protocols, they did not reach 100% effectiveness in the time required for approved pharmaceutical products against sheep scab, according to Argentine regulations. Estación Experimental Agropecuaria Bariloche Fil: Larroza, Marcela Patricia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área Producción Animal. Grupo Sanidad Animal; Argentina Fil: Soler, Paula. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área Producción Animal. Grupo Sanidad Animal; Argentina Fil: Robles, Carlos Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Area de Produccion Animal. Grupo de Sanidad Animal; Argentina Fil: Cabrera, Francisco Raúl. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Area de Produccion Animal. Grupo de Sanidad Animal; Argentina Fil: Ballent, Mariana. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias.Centro de Investigación Veterinaria de Tandil. Laboratorio de Farmacología; Argentina Fil: Lanusse, Carlos. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias.Centro de Investigación Veterinaria de Tandil. Laboratorio de Farmacología; Argentina Fil: Lifschitz, Adrián Luis. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias.Centro de Investigación Veterinaria de Tandil. Laboratorio de Farmacología; Argentina 2020-10-20T14:52:19Z 2020-10-20T14:52:19Z 2020-11 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/8088 https://www.sciencedirect.com/science/article/abs/pii/S001448942030196X 0014-4894 https://doi.org/10.1016/j.exppara.2020.107998 eng info:eu-repo/semantics/restrictedAccess application/pdf Elsevier Experimental Parasitology 218 : Art:107998 (Noviembre 2020) |
| spellingShingle | Psoroptes Ovis Enfermedades de los Animales Control de Enfermedades Animal Diseases Disease Control DRM Larroza, Marcela Patricia Soler, Paula Robles, Carlos Alejandro Cabrera, Francisco Raúl Ballent, Mariana Lanusse, Carlos Lifschitz, Adrian Luis Doramectin efficacy against Psoroptes ovis in sheep: Evaluation of pharmacological strategies |
| title | Doramectin efficacy against Psoroptes ovis in sheep: Evaluation of pharmacological strategies |
| title_full | Doramectin efficacy against Psoroptes ovis in sheep: Evaluation of pharmacological strategies |
| title_fullStr | Doramectin efficacy against Psoroptes ovis in sheep: Evaluation of pharmacological strategies |
| title_full_unstemmed | Doramectin efficacy against Psoroptes ovis in sheep: Evaluation of pharmacological strategies |
| title_short | Doramectin efficacy against Psoroptes ovis in sheep: Evaluation of pharmacological strategies |
| title_sort | doramectin efficacy against psoroptes ovis in sheep evaluation of pharmacological strategies |
| topic | Psoroptes Ovis Enfermedades de los Animales Control de Enfermedades Animal Diseases Disease Control DRM |
| url | http://hdl.handle.net/20.500.12123/8088 https://www.sciencedirect.com/science/article/abs/pii/S001448942030196X https://doi.org/10.1016/j.exppara.2020.107998 |
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