Does Mycobacterium bovis persist in cattle in a non-replicative latent state as Mycobacterium tuberculosis in human beings?
Members of the Mycobacterium tuberculosis complex (MTBC) are responsible for tuberculosis in several mammals. In this complex, Mycobacterium tuberculosis and Mycobacterium bovis, which are closely related, show host preference for humans and cattle, respectively. Although human and bovine tuberculos...
| Autores principales: | , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/7981 https://www.sciencedirect.com/science/article/pii/S037811352030359X https://doi.org/10.1016/j.vetmic.2020.108758 |
| _version_ | 1855484111224832000 |
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| author | Sabio Y Garcia, Julia Veronica Bigi, María Mercedes Klepp, Laura Ines Garcia, Elizabeth Andrea Blanco, Federico Carlos Bigi, Fabiana |
| author_browse | Bigi, Fabiana Bigi, María Mercedes Blanco, Federico Carlos Garcia, Elizabeth Andrea Klepp, Laura Ines Sabio Y Garcia, Julia Veronica |
| author_facet | Sabio Y Garcia, Julia Veronica Bigi, María Mercedes Klepp, Laura Ines Garcia, Elizabeth Andrea Blanco, Federico Carlos Bigi, Fabiana |
| author_sort | Sabio Y Garcia, Julia Veronica |
| collection | INTA Digital |
| description | Members of the Mycobacterium tuberculosis complex (MTBC) are responsible for tuberculosis in several mammals. In this complex, Mycobacterium tuberculosis and Mycobacterium bovis, which are closely related, show host preference for humans and cattle, respectively. Although human and bovine tuberculosis are clinically similar, M. tuberculosis mostly causes latent infection in humans, whereas M. bovis frequently leads to an acute infection in cattle. This review attempts to connect the pathology in experimental animal models as well as the cellular responses to M. bovis and M. tuberculosis regarding the differences in protein expression and regulatory mechanisms of both pathogens that could explain their apparent divergent latency behaviour. The occurrence of latent bovine tuberculosis (bTB) would represent a serious complication for the eradication of the disease in cattle, with the risk of onward transmission to humans. Thus, understanding the physiological events that may lead to the state of latency in bTB could assist in the development of appropriate prevention and control tools. |
| format | Artículo |
| id | INTA7981 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA79812020-09-28T17:03:25Z Does Mycobacterium bovis persist in cattle in a non-replicative latent state as Mycobacterium tuberculosis in human beings? Sabio Y Garcia, Julia Veronica Bigi, María Mercedes Klepp, Laura Ines Garcia, Elizabeth Andrea Blanco, Federico Carlos Bigi, Fabiana Mycobacterium bovis Mycobacterium tuberculosis Infecciones Latentes Ganado Bovino Género Humano Latent Infections Cattle Humans Members of the Mycobacterium tuberculosis complex (MTBC) are responsible for tuberculosis in several mammals. In this complex, Mycobacterium tuberculosis and Mycobacterium bovis, which are closely related, show host preference for humans and cattle, respectively. Although human and bovine tuberculosis are clinically similar, M. tuberculosis mostly causes latent infection in humans, whereas M. bovis frequently leads to an acute infection in cattle. This review attempts to connect the pathology in experimental animal models as well as the cellular responses to M. bovis and M. tuberculosis regarding the differences in protein expression and regulatory mechanisms of both pathogens that could explain their apparent divergent latency behaviour. The occurrence of latent bovine tuberculosis (bTB) would represent a serious complication for the eradication of the disease in cattle, with the risk of onward transmission to humans. Thus, understanding the physiological events that may lead to the state of latency in bTB could assist in the development of appropriate prevention and control tools. Instituto de Biotecnología Fil: Sabio Y Garcia, Julia Veronica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Bigi, María Mercedes. Universidad de Buenos Aires. Facultad de Agronomía. Cátedra de Microbiología Agrícola; Argentina Fil: Klepp, Laura Ines. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Garcia, Elizabeth Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2020-09-28T16:57:59Z 2020-09-28T16:57:59Z 2020-08 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/7981 https://www.sciencedirect.com/science/article/pii/S037811352030359X 0378-1135 https://doi.org/10.1016/j.vetmic.2020.108758 eng info:eu-repo/semantics/restrictedAccess application/pdf Elsevier Veterinary Microbiology 247 : 108758 (Agosto 2020) |
| spellingShingle | Mycobacterium bovis Mycobacterium tuberculosis Infecciones Latentes Ganado Bovino Género Humano Latent Infections Cattle Humans Sabio Y Garcia, Julia Veronica Bigi, María Mercedes Klepp, Laura Ines Garcia, Elizabeth Andrea Blanco, Federico Carlos Bigi, Fabiana Does Mycobacterium bovis persist in cattle in a non-replicative latent state as Mycobacterium tuberculosis in human beings? |
| title | Does Mycobacterium bovis persist in cattle in a non-replicative latent state as Mycobacterium tuberculosis in human beings? |
| title_full | Does Mycobacterium bovis persist in cattle in a non-replicative latent state as Mycobacterium tuberculosis in human beings? |
| title_fullStr | Does Mycobacterium bovis persist in cattle in a non-replicative latent state as Mycobacterium tuberculosis in human beings? |
| title_full_unstemmed | Does Mycobacterium bovis persist in cattle in a non-replicative latent state as Mycobacterium tuberculosis in human beings? |
| title_short | Does Mycobacterium bovis persist in cattle in a non-replicative latent state as Mycobacterium tuberculosis in human beings? |
| title_sort | does mycobacterium bovis persist in cattle in a non replicative latent state as mycobacterium tuberculosis in human beings |
| topic | Mycobacterium bovis Mycobacterium tuberculosis Infecciones Latentes Ganado Bovino Género Humano Latent Infections Cattle Humans |
| url | http://hdl.handle.net/20.500.12123/7981 https://www.sciencedirect.com/science/article/pii/S037811352030359X https://doi.org/10.1016/j.vetmic.2020.108758 |
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