Fatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine Patagonia
The present study describes the spontaneous and experimental poisoning of goats by Festuca argentina in Argentine Patagonia. In April 2017, eight seven-month-old Creole male goats were accidentally introduced into a paddock that contained F. argentina. After four days, two of the goats were found de...
| Main Authors: | , , , , , , , , |
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| Format: | info:ar-repo/semantics/artículo |
| Language: | Inglés |
| Published: |
Elsevier
2020
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.12123/7765 https://www.sciencedirect.com/science/article/abs/pii/S0041010120303445 https://doi.org/10.1016/j.toxicon.2020.08.004 |
| _version_ | 1855035916805996544 |
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| author | Martinez, Agustin Cook, Daniel Lee, Stephen T. Sola, Diego Bain, Luciana Borrelli, Laura Beatriz Acín, Cristina Gardner, Dale R. Robles, Carlos Alejandro |
| author_browse | Acín, Cristina Bain, Luciana Borrelli, Laura Beatriz Cook, Daniel Gardner, Dale R. Lee, Stephen T. Martinez, Agustin Robles, Carlos Alejandro Sola, Diego |
| author_facet | Martinez, Agustin Cook, Daniel Lee, Stephen T. Sola, Diego Bain, Luciana Borrelli, Laura Beatriz Acín, Cristina Gardner, Dale R. Robles, Carlos Alejandro |
| author_sort | Martinez, Agustin |
| collection | INTA Digital |
| description | The present study describes the spontaneous and experimental poisoning of goats by Festuca argentina in Argentine Patagonia. In April 2017, eight seven-month-old Creole male goats were accidentally introduced into a paddock that contained F. argentina. After four days, two of the goats were found dead and four out of the six remaining goats were clinically affected. Two of the latter had to be later euthanized in extremis. The main clinical signs were progressive nervous signs, starting with moderate muscle tremors, wide-based stance and ataxia. Postmortem examination was performed on the two euthanized goats. Epidermal fragments of F. argentina
were found in the rumen samples from the necropsied goats and the fecal samples from the four affected goats. For the experimental poisoning, fresh sheaths of F. argentina collected from the paddock were offered to two goats at 10 g/kg body weight for 3 days. After 24–36 h, both animals exhibited severe muscle tremors, reluctance to move, tetanic convulsions, and opisthotonus. In both the spontaneously and experimentally poisoned goats, gross lesions were similar and consisted of dehydration, petechial hemorrhages in the epicardium and congestion. The main microscopic findings consisted of degeneration and loss of Purkinje cells and torpedoes in the granular layer of the cerebellum. The F. argentina sheaths collected from the pasture were found to contain tremorgenic indole-diterpene alkaloids. Taken together, the results of the present study suggest that the tremorgenic syndrome observed in the spontaneously poisoned goats was due to poisoning by F. argentina. |
| format | info:ar-repo/semantics/artículo |
| id | INTA7765 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA77652020-08-25T11:44:53Z Fatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine Patagonia Martinez, Agustin Cook, Daniel Lee, Stephen T. Sola, Diego Bain, Luciana Borrelli, Laura Beatriz Acín, Cristina Gardner, Dale R. Robles, Carlos Alejandro Envenenamiento Toxicidad por Ingestión Festuca Cabra Caprinos Enfermedades de los Animales Poisoning Ingestion Toxicity Nannygoats Goats Animal Diseases Región Patagónica Festuca Argentina Cabras Criollas The present study describes the spontaneous and experimental poisoning of goats by Festuca argentina in Argentine Patagonia. In April 2017, eight seven-month-old Creole male goats were accidentally introduced into a paddock that contained F. argentina. After four days, two of the goats were found dead and four out of the six remaining goats were clinically affected. Two of the latter had to be later euthanized in extremis. The main clinical signs were progressive nervous signs, starting with moderate muscle tremors, wide-based stance and ataxia. Postmortem examination was performed on the two euthanized goats. Epidermal fragments of F. argentina were found in the rumen samples from the necropsied goats and the fecal samples from the four affected goats. For the experimental poisoning, fresh sheaths of F. argentina collected from the paddock were offered to two goats at 10 g/kg body weight for 3 days. After 24–36 h, both animals exhibited severe muscle tremors, reluctance to move, tetanic convulsions, and opisthotonus. In both the spontaneously and experimentally poisoned goats, gross lesions were similar and consisted of dehydration, petechial hemorrhages in the epicardium and congestion. The main microscopic findings consisted of degeneration and loss of Purkinje cells and torpedoes in the granular layer of the cerebellum. The F. argentina sheaths collected from the pasture were found to contain tremorgenic indole-diterpene alkaloids. Taken together, the results of the present study suggest that the tremorgenic syndrome observed in the spontaneously poisoned goats was due to poisoning by F. argentina. Estación Experimental Agropecuaria Bariloche Fil: Martinez, Agustin. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área Producción Animal. Grupo Sanidad Animal; Argentina Fil: Cook, Daniel. US Department of Agriculture. Agricultural Research Service (ARS). Poisonous Plant Research Laboratory; Estados Unidos Fil: Lee, Stephen T. US Department of Agriculture. Agricultural Research Service (ARS). Poisonous Plant Research Laboratory; Estados Unidos Fil: Sola, Diego. Universidad de Zaragoza. Centro de Encefalopatías y Enfermedades Transmisibles Emergentes; España Fil: Bain, Luciana. Universidad Nacional del Centro de la Povincia de Buenos Aires; Argentina Fil: Borrelli, Laura Beatriz. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Laboratorio de Microhistología; Argentina Fil: Acín, Cristina. Universidad de Zaragoza. Centro de Encefalopatías y Enfermedades Transmisibles Emergentes; España Fil: Gardner, Dale R. US Department of Agriculture. Agricultural Research Service (ARS). Poisonous Plant Research Laboratory; Estados Unidos Fil: Robles, Carlos Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Area de Produccion Animal. Grupo de Sanidad Animal; Argentina 2020-08-25T11:37:08Z 2020-08-25T11:37:08Z 2020-10-30 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/7765 https://www.sciencedirect.com/science/article/abs/pii/S0041010120303445 0041-0101 https://doi.org/10.1016/j.toxicon.2020.08.004 eng info:eu-repo/semantics/restrictedAccess application/pdf Elsevier Toxicon 186 : 191-197 (Octubre 2020) |
| spellingShingle | Envenenamiento Toxicidad por Ingestión Festuca Cabra Caprinos Enfermedades de los Animales Poisoning Ingestion Toxicity Nannygoats Goats Animal Diseases Región Patagónica Festuca Argentina Cabras Criollas Martinez, Agustin Cook, Daniel Lee, Stephen T. Sola, Diego Bain, Luciana Borrelli, Laura Beatriz Acín, Cristina Gardner, Dale R. Robles, Carlos Alejandro Fatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine Patagonia |
| title | Fatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine Patagonia |
| title_full | Fatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine Patagonia |
| title_fullStr | Fatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine Patagonia |
| title_full_unstemmed | Fatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine Patagonia |
| title_short | Fatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine Patagonia |
| title_sort | fatal stagger poisoning by consumption of festuca argentina speg parodi in goats from argentine patagonia |
| topic | Envenenamiento Toxicidad por Ingestión Festuca Cabra Caprinos Enfermedades de los Animales Poisoning Ingestion Toxicity Nannygoats Goats Animal Diseases Región Patagónica Festuca Argentina Cabras Criollas |
| url | http://hdl.handle.net/20.500.12123/7765 https://www.sciencedirect.com/science/article/abs/pii/S0041010120303445 https://doi.org/10.1016/j.toxicon.2020.08.004 |
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