Dynamics of neutralizing antibodies against Bovine respiratory syncytial virus in a dairy herd from Santa Fe Province, Argentina = Dinámica de anticuerpos neutralizantes contra el virus respiratorio sincitial bovino en un rodeo lechero de la provincia de Santa Fe, Argentina
Bovine respiratory syncytial virus (BRSV) is one of the most relevant agents responsible for respiratory disease in cattle from both dairy and beef farms. BRSV is spread by horizontal contact causing a constant presence of seropositive animals that favors viral circulation throughout the year. Moreo...
| Main Authors: | , , , , , |
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| Format: | Artículo |
| Language: | Inglés |
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Elsevier
2020
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| Online Access: | http://hdl.handle.net/20.500.12123/7758 https://www.sciencedirect.com/science/article/pii/S0325754120300274 https://doi.org/10.1016/j.ram.2020.04.003 |
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| author | Ferella, Alejandra Perez Aguirreburiald, Maria Sol Sammarruco, Romina Ayelén Parreño, Viviana Dus Santos, Maria Jose Mozgovoj, Marina Valeria |
| author_browse | Dus Santos, Maria Jose Ferella, Alejandra Mozgovoj, Marina Valeria Parreño, Viviana Perez Aguirreburiald, Maria Sol Sammarruco, Romina Ayelén |
| author_facet | Ferella, Alejandra Perez Aguirreburiald, Maria Sol Sammarruco, Romina Ayelén Parreño, Viviana Dus Santos, Maria Jose Mozgovoj, Marina Valeria |
| author_sort | Ferella, Alejandra |
| collection | INTA Digital |
| description | Bovine respiratory syncytial virus (BRSV) is one of the most relevant agents responsible for respiratory disease in cattle from both dairy and beef farms. BRSV is spread by horizontal contact causing a constant presence of seropositive animals that favors viral circulation throughout the year. Moreover, reinfections with BRSV are frequent between animals regardless of their age as BRSV does not confer long-lasting protective immunity. Several studies have demonstrated the circulation of BRSV in cattle from different regions of the world; however, little is known about the dynamics of BRSV infection in cows before and after they begin lactation. The aim of this work was to study the dynamics of BRSV neutralizing antibodies from birth up to 36 months of age in a closed dairy herd of Argentina specifically around the lactation period. Passive maternal antibodies against BRSV started to decrease monthly and became almost undetectable at 8 months of age. We detected two potential infection points at months 11 and 27 after birth, in which 30% and 45% of the animals showed seroconversion, respectively. Specifically, an increase in the proportion of seropositive cows after the start of lactation suggests that they became reinfected around the time they began lactating. We demonstrate the importance of understanding BRSV dynamics in a closed dairy herd to review the vaccination schedule of the animals to achieve protection against BRSV infection. |
| format | Artículo |
| id | INTA7758 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA77582020-08-21T14:43:15Z Dynamics of neutralizing antibodies against Bovine respiratory syncytial virus in a dairy herd from Santa Fe Province, Argentina = Dinámica de anticuerpos neutralizantes contra el virus respiratorio sincitial bovino en un rodeo lechero de la provincia de Santa Fe, Argentina Ferella, Alejandra Perez Aguirreburiald, Maria Sol Sammarruco, Romina Ayelén Parreño, Viviana Dus Santos, Maria Jose Mozgovoj, Marina Valeria Ganado Bovino Enfermedades de los Animales Virus Sincitial Respiratorio Bovino Anticuerpos Ganado de Leche Cattle Animal Diseases Bovine Respiratory Syncytial Virus Antibodies Dairy Cattle Santa Fé, Argentina Bovine respiratory syncytial virus (BRSV) is one of the most relevant agents responsible for respiratory disease in cattle from both dairy and beef farms. BRSV is spread by horizontal contact causing a constant presence of seropositive animals that favors viral circulation throughout the year. Moreover, reinfections with BRSV are frequent between animals regardless of their age as BRSV does not confer long-lasting protective immunity. Several studies have demonstrated the circulation of BRSV in cattle from different regions of the world; however, little is known about the dynamics of BRSV infection in cows before and after they begin lactation. The aim of this work was to study the dynamics of BRSV neutralizing antibodies from birth up to 36 months of age in a closed dairy herd of Argentina specifically around the lactation period. Passive maternal antibodies against BRSV started to decrease monthly and became almost undetectable at 8 months of age. We detected two potential infection points at months 11 and 27 after birth, in which 30% and 45% of the animals showed seroconversion, respectively. Specifically, an increase in the proportion of seropositive cows after the start of lactation suggests that they became reinfected around the time they began lactating. We demonstrate the importance of understanding BRSV dynamics in a closed dairy herd to review the vaccination schedule of the animals to achieve protection against BRSV infection. El virus respiratorio sincitial bovino (Bovine respiratory syncytial virus, [BRSV]) es uno de los principales agentes responsables de la enfermedad respiratoria en bovinos, tanto de tambos como de cría. El virus se transmite horizontalmente y causa la presencia constante de animales seropositivos, lo cual favorece la circulación viral a lo largo del año. A su vez, las reinfecciones por BRSV son frecuentes entre animales independientemente de su edad, dado que el virus no confiere inmunidad protectora a largo plazo. Numerosos estudios han demostrado la circulación de BRSV en bovinos de diferentes regiones del mundo, sin embargo, poco se conoce acerca de la dinámica de infección en vacas antes y después del inicio de la fase de lactancia. El objetivo de este trabajo fue estudiar la dinámica de anticuerpos neutralizantes anti- BRSV en vacas lecheras desde el nacimiento hasta los 36 meses de vida en un tambo cerrado de Argentina, específicamente, en el período de lactancia. Los anticuerpos pasivos específicos para BRSV comenzaron a declinar mensualmente hasta ser casi indetectables a los 6 meses. Detectamos dos potenciales puntos de infección a los meses 11 y 27 luego del nacimiento, momentos en los que el 30 y el 45% de los animales mostraron seroconversión, respectivamente. El incremento en la proporción de vacas seropositivas luego del comienzo de la lactancia sugiere que estas se reinfectaron en el inicio de dicha etapa. Demostramos la importancia de entender la dinámica de circulación del BRSV en un tambo cerrado, a fin de revisar el esquema de vacunación de los animales para que estén protegidos frente a la posible infección por este virus. Instituto de Virología Fil: Ferella, Alejandra. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Pérez Aguirreburualde, María Sol. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Sammarruco, Romina Ayelén. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Parreño, Viviana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Dus Santos, Maria Jose. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Mozgovoj, Marina Valeria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2020-08-21T14:40:19Z 2020-08-21T14:40:19Z 2020-05 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion http://hdl.handle.net/20.500.12123/7758 https://www.sciencedirect.com/science/article/pii/S0325754120300274 0325-7541 1851-7617 https://doi.org/10.1016/j.ram.2020.04.003 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Elsevier Revista Argentina de Microbiología (Available online 11 May 2020) |
| spellingShingle | Ganado Bovino Enfermedades de los Animales Virus Sincitial Respiratorio Bovino Anticuerpos Ganado de Leche Cattle Animal Diseases Bovine Respiratory Syncytial Virus Antibodies Dairy Cattle Santa Fé, Argentina Ferella, Alejandra Perez Aguirreburiald, Maria Sol Sammarruco, Romina Ayelén Parreño, Viviana Dus Santos, Maria Jose Mozgovoj, Marina Valeria Dynamics of neutralizing antibodies against Bovine respiratory syncytial virus in a dairy herd from Santa Fe Province, Argentina = Dinámica de anticuerpos neutralizantes contra el virus respiratorio sincitial bovino en un rodeo lechero de la provincia de Santa Fe, Argentina |
| title | Dynamics of neutralizing antibodies against Bovine respiratory syncytial virus in a dairy herd from Santa Fe Province, Argentina = Dinámica de anticuerpos neutralizantes contra el virus respiratorio sincitial bovino en un rodeo lechero de la provincia de Santa Fe, Argentina |
| title_full | Dynamics of neutralizing antibodies against Bovine respiratory syncytial virus in a dairy herd from Santa Fe Province, Argentina = Dinámica de anticuerpos neutralizantes contra el virus respiratorio sincitial bovino en un rodeo lechero de la provincia de Santa Fe, Argentina |
| title_fullStr | Dynamics of neutralizing antibodies against Bovine respiratory syncytial virus in a dairy herd from Santa Fe Province, Argentina = Dinámica de anticuerpos neutralizantes contra el virus respiratorio sincitial bovino en un rodeo lechero de la provincia de Santa Fe, Argentina |
| title_full_unstemmed | Dynamics of neutralizing antibodies against Bovine respiratory syncytial virus in a dairy herd from Santa Fe Province, Argentina = Dinámica de anticuerpos neutralizantes contra el virus respiratorio sincitial bovino en un rodeo lechero de la provincia de Santa Fe, Argentina |
| title_short | Dynamics of neutralizing antibodies against Bovine respiratory syncytial virus in a dairy herd from Santa Fe Province, Argentina = Dinámica de anticuerpos neutralizantes contra el virus respiratorio sincitial bovino en un rodeo lechero de la provincia de Santa Fe, Argentina |
| title_sort | dynamics of neutralizing antibodies against bovine respiratory syncytial virus in a dairy herd from santa fe province argentina dinamica de anticuerpos neutralizantes contra el virus respiratorio sincitial bovino en un rodeo lechero de la provincia de santa fe argentina |
| topic | Ganado Bovino Enfermedades de los Animales Virus Sincitial Respiratorio Bovino Anticuerpos Ganado de Leche Cattle Animal Diseases Bovine Respiratory Syncytial Virus Antibodies Dairy Cattle Santa Fé, Argentina |
| url | http://hdl.handle.net/20.500.12123/7758 https://www.sciencedirect.com/science/article/pii/S0325754120300274 https://doi.org/10.1016/j.ram.2020.04.003 |
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