Reduction of foot-and-mouth disease virus transmission in cattle vaccinated one or two weeks before challenge using a commercial polyvalent vaccine
Immediate vaccination of the most susceptible and epidemiological relevant animals is a crucial part of control measures that facilitate virus elimination in case of entry of foot-and-mouth disease (FMD). The objective of this study was to evaluate the effect of cattle vaccination 7 and 14 days prio...
| Autores principales: | , , , , , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/7675 https://www.sciencedirect.com/science/article/pii/S2590136220300103 https://doi.org/10.1016/j.jvacx.2020.100063 |
| _version_ | 1855035901414998016 |
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| author | Duffy, Sergio Fondevila, Norberto Antonio Galdo Novo, Sabrina Aznar, Maria Natalia Garro, Carlos Javier Smitsaart, Eliana Monti, Gustavo |
| author_browse | Aznar, Maria Natalia Duffy, Sergio Fondevila, Norberto Antonio Galdo Novo, Sabrina Garro, Carlos Javier Monti, Gustavo Smitsaart, Eliana |
| author_facet | Duffy, Sergio Fondevila, Norberto Antonio Galdo Novo, Sabrina Aznar, Maria Natalia Garro, Carlos Javier Smitsaart, Eliana Monti, Gustavo |
| author_sort | Duffy, Sergio |
| collection | INTA Digital |
| description | Immediate vaccination of the most susceptible and epidemiological relevant animals is a crucial part of control measures that facilitate virus elimination in case of entry of foot-and-mouth disease (FMD). The objective of this study was to evaluate the effect of cattle vaccination 7 and 14 days prior challenge using a vaccine commonly applied in systematic vaccination campaigns against transmission of FMD virus (FMDV). Transmission of FMDV was investigated in three groups of ten cattle each: one non-vaccinated group and two groups that were either vaccinated 7 days (−7/vaccinated group) or 14 days (−14/vaccinated group) before intranasal (IN) inoculation. Five cattle heads from each group were inoculated using the IN-route with the A/Argentina/2001 FMDV strain, while the remaining five cattle heads of each group were contact-exposed to inoculated cattle. Clinical signs were recorded; virus isolation and genome detection by RT-PCR were carried out on oesophageal–pharyngeal fluid (OPF) and blood. Neutralizing antibody titers and antibodies against non-structural proteins (NSP) of FMDV were also determined. Results suggest that the experimental design, virus challenge dose, and virus infectivity were appropriate and that the virus had been transmitted to naïve calves. Under the outlined experimental conditions, vaccination 7 and 14 days prior to challenge induced full clinical protection against virus inoculation. Moreover, −7/ or −14/vaccinated calves that had been contact-exposed to −7/ or −14/vaccinated IN-challenged calves, did not become infected. Consequently, no virus transmission occurred from vaccinated and subsequently infected calves to cohabitating vaccinated calves (R = 0). According to our results, early vaccination during an outbreak is effective as virus transmission can be significantly reduced using a vaccine commercially available, routinely applied in systematic vaccination campaigns. |
| format | info:ar-repo/semantics/artículo |
| id | INTA7675 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA76752020-08-05T19:26:13Z Reduction of foot-and-mouth disease virus transmission in cattle vaccinated one or two weeks before challenge using a commercial polyvalent vaccine Duffy, Sergio Fondevila, Norberto Antonio Galdo Novo, Sabrina Aznar, Maria Natalia Garro, Carlos Javier Smitsaart, Eliana Monti, Gustavo Enfermedades de los Animales Fiebre Aftosa Ganado Bovino Vacunación Control de Enfermedades Animal Diseases Foot and Mouth Disease Cattle Vaccination Diseases Control Immediate vaccination of the most susceptible and epidemiological relevant animals is a crucial part of control measures that facilitate virus elimination in case of entry of foot-and-mouth disease (FMD). The objective of this study was to evaluate the effect of cattle vaccination 7 and 14 days prior challenge using a vaccine commonly applied in systematic vaccination campaigns against transmission of FMD virus (FMDV). Transmission of FMDV was investigated in three groups of ten cattle each: one non-vaccinated group and two groups that were either vaccinated 7 days (−7/vaccinated group) or 14 days (−14/vaccinated group) before intranasal (IN) inoculation. Five cattle heads from each group were inoculated using the IN-route with the A/Argentina/2001 FMDV strain, while the remaining five cattle heads of each group were contact-exposed to inoculated cattle. Clinical signs were recorded; virus isolation and genome detection by RT-PCR were carried out on oesophageal–pharyngeal fluid (OPF) and blood. Neutralizing antibody titers and antibodies against non-structural proteins (NSP) of FMDV were also determined. Results suggest that the experimental design, virus challenge dose, and virus infectivity were appropriate and that the virus had been transmitted to naïve calves. Under the outlined experimental conditions, vaccination 7 and 14 days prior to challenge induced full clinical protection against virus inoculation. Moreover, −7/ or −14/vaccinated calves that had been contact-exposed to −7/ or −14/vaccinated IN-challenged calves, did not become infected. Consequently, no virus transmission occurred from vaccinated and subsequently infected calves to cohabitating vaccinated calves (R = 0). According to our results, early vaccination during an outbreak is effective as virus transmission can be significantly reduced using a vaccine commercially available, routinely applied in systematic vaccination campaigns. Instituto de Patobiología Fil: Duffy, Sergio. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina Fil: Fondevila, Norberto Antonio. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Galdo Novo, Sabrina. Servicio Nacional de Sanidad y Calidad Agroalimentaria (SENASA); Argentina Fil: Aznar, Maria Natalia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina Fil: Garro, Carlos Javier. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina Fil: Smitsaart, Eliana N. Biogénesis Bagó S.A.; Argentina Fil: Monti, Gustavo. Universidad Austral de Chile. Facultad de Ciencias Veterinarias; Chile 2020-08-05T19:21:57Z 2020-08-05T19:21:57Z 2020-08 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/7675 https://www.sciencedirect.com/science/article/pii/S2590136220300103 2590-1362 https://doi.org/10.1016/j.jvacx.2020.100063 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Elsevier Vaccine: X 5 : 100063 (August 2020) |
| spellingShingle | Enfermedades de los Animales Fiebre Aftosa Ganado Bovino Vacunación Control de Enfermedades Animal Diseases Foot and Mouth Disease Cattle Vaccination Diseases Control Duffy, Sergio Fondevila, Norberto Antonio Galdo Novo, Sabrina Aznar, Maria Natalia Garro, Carlos Javier Smitsaart, Eliana Monti, Gustavo Reduction of foot-and-mouth disease virus transmission in cattle vaccinated one or two weeks before challenge using a commercial polyvalent vaccine |
| title | Reduction of foot-and-mouth disease virus transmission in cattle vaccinated one or two weeks before challenge using a commercial polyvalent vaccine |
| title_full | Reduction of foot-and-mouth disease virus transmission in cattle vaccinated one or two weeks before challenge using a commercial polyvalent vaccine |
| title_fullStr | Reduction of foot-and-mouth disease virus transmission in cattle vaccinated one or two weeks before challenge using a commercial polyvalent vaccine |
| title_full_unstemmed | Reduction of foot-and-mouth disease virus transmission in cattle vaccinated one or two weeks before challenge using a commercial polyvalent vaccine |
| title_short | Reduction of foot-and-mouth disease virus transmission in cattle vaccinated one or two weeks before challenge using a commercial polyvalent vaccine |
| title_sort | reduction of foot and mouth disease virus transmission in cattle vaccinated one or two weeks before challenge using a commercial polyvalent vaccine |
| topic | Enfermedades de los Animales Fiebre Aftosa Ganado Bovino Vacunación Control de Enfermedades Animal Diseases Foot and Mouth Disease Cattle Vaccination Diseases Control |
| url | http://hdl.handle.net/20.500.12123/7675 https://www.sciencedirect.com/science/article/pii/S2590136220300103 https://doi.org/10.1016/j.jvacx.2020.100063 |
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