Repeated maternal separation: Alcohol consumption, anxious behavior and corticosterone were reversed by a non-pharmacological treatment
Adverse events in early life have been related to a maladaptive stress response during adulthood, which could predispose individuals to psychiatric and physiological disorders. The purpose of this work was to study the implications of repeated maternal separation (RMS) plus a physical stressor (cold...
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| Format: | info:ar-repo/semantics/artículo |
| Language: | Inglés |
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Elsevier
2020
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| Online Access: | http://hdl.handle.net/20.500.12123/7628 https://www.sciencedirect.com/science/article/abs/pii/S027858461930497X https://doi.org/10.1016/j.pnpbp.2019.109726 |
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| author | Odeon, Maria Mercedes Acosta, Gabriela Beatriz |
| author_browse | Acosta, Gabriela Beatriz Odeon, Maria Mercedes |
| author_facet | Odeon, Maria Mercedes Acosta, Gabriela Beatriz |
| author_sort | Odeon, Maria Mercedes |
| collection | INTA Digital |
| description | Adverse events in early life have been related to a maladaptive stress response during adulthood, which could predispose individuals to psychiatric and physiological disorders. The purpose of this work was to study the implications of repeated maternal separation (RMS) plus a physical stressor (cold stress), voluntary ethanol consumption and plasmatic levels of corticosterone (Cor) via conflict behavior tests. To this aim, pups were separated daily from their mothers for one hour and subjected to cold stress (4 °C) between postnatal days (PD) 2 and 20. Control groups were left undisturbed with their mothers. Afterwards, all groups were exposed to voluntary ethanol (6%) or dextrose (1%) intake for 7 days. After a 30-day period of environmental enrichment (EE), the animals were again exposed to the voluntary intake protocol for 7 days. At 66 days, they were subjected to different conflict tests. Thereafter, rats were sacrificed by decapitation and blood trunk was collected to determine plasma corticosterone levels. We demonstrated that early RMS increased both voluntary alcohol intake and Cor levels. Moreover, young adult animals showed excessive activity in conflict tests. Whereas in animals exposed to a non-pharmacological treatment, known as environmental enrichment (EE), the effects
previously obtained were reversed and/or prevented. In summary, we can conclude that the combination of
maternal separation in early life plus cold stress increase both the voluntary exposure to alcohol and disruptive
behaviors. This is a risk factor for the development of chronic diseases such as alcoholism and long-term depression.
However, we found that an enriched environment may have a beneficial effect with respect to alcohol intake and aggressive behaviors. |
| format | info:ar-repo/semantics/artículo |
| id | INTA7628 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA76282020-07-28T16:54:31Z Repeated maternal separation: Alcohol consumption, anxious behavior and corticosterone were reversed by a non-pharmacological treatment Odeon, Maria Mercedes Acosta, Gabriela Beatriz Respuesta a la Selección Estrés de Frío Tolerancia al Frío Corticosterona Selection Responses Cold Stress Cold Tolerance Corticosterone Paramétros de Comportamiento Adverse events in early life have been related to a maladaptive stress response during adulthood, which could predispose individuals to psychiatric and physiological disorders. The purpose of this work was to study the implications of repeated maternal separation (RMS) plus a physical stressor (cold stress), voluntary ethanol consumption and plasmatic levels of corticosterone (Cor) via conflict behavior tests. To this aim, pups were separated daily from their mothers for one hour and subjected to cold stress (4 °C) between postnatal days (PD) 2 and 20. Control groups were left undisturbed with their mothers. Afterwards, all groups were exposed to voluntary ethanol (6%) or dextrose (1%) intake for 7 days. After a 30-day period of environmental enrichment (EE), the animals were again exposed to the voluntary intake protocol for 7 days. At 66 days, they were subjected to different conflict tests. Thereafter, rats were sacrificed by decapitation and blood trunk was collected to determine plasma corticosterone levels. We demonstrated that early RMS increased both voluntary alcohol intake and Cor levels. Moreover, young adult animals showed excessive activity in conflict tests. Whereas in animals exposed to a non-pharmacological treatment, known as environmental enrichment (EE), the effects previously obtained were reversed and/or prevented. In summary, we can conclude that the combination of maternal separation in early life plus cold stress increase both the voluntary exposure to alcohol and disruptive behaviors. This is a risk factor for the development of chronic diseases such as alcoholism and long-term depression. However, we found that an enriched environment may have a beneficial effect with respect to alcohol intake and aggressive behaviors. Estación Experimental Agropecuaria Bariloche Fil: Odeon, Maria Mercedes. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Consejo Nacional de Investigaciones Cientıicas y Tecnicas. Instituto de Investigaciones Forestales y Agropecuarias Bariloche; Argentina Fil: Acosta, Gabriela Beatriz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2020-07-28T16:38:09Z 2020-07-28T16:38:09Z 2019-12-29 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/7628 https://www.sciencedirect.com/science/article/abs/pii/S027858461930497X 0278-5846 https://doi.org/10.1016/j.pnpbp.2019.109726 eng info:eu-repo/semantics/restrictedAccess application/pdf Elsevier Progress in Neuropsychopharmacology & Biological Psychiatry 95 : 109726 (2019) |
| spellingShingle | Respuesta a la Selección Estrés de Frío Tolerancia al Frío Corticosterona Selection Responses Cold Stress Cold Tolerance Corticosterone Paramétros de Comportamiento Odeon, Maria Mercedes Acosta, Gabriela Beatriz Repeated maternal separation: Alcohol consumption, anxious behavior and corticosterone were reversed by a non-pharmacological treatment |
| title | Repeated maternal separation: Alcohol consumption, anxious behavior and corticosterone were reversed by a non-pharmacological treatment |
| title_full | Repeated maternal separation: Alcohol consumption, anxious behavior and corticosterone were reversed by a non-pharmacological treatment |
| title_fullStr | Repeated maternal separation: Alcohol consumption, anxious behavior and corticosterone were reversed by a non-pharmacological treatment |
| title_full_unstemmed | Repeated maternal separation: Alcohol consumption, anxious behavior and corticosterone were reversed by a non-pharmacological treatment |
| title_short | Repeated maternal separation: Alcohol consumption, anxious behavior and corticosterone were reversed by a non-pharmacological treatment |
| title_sort | repeated maternal separation alcohol consumption anxious behavior and corticosterone were reversed by a non pharmacological treatment |
| topic | Respuesta a la Selección Estrés de Frío Tolerancia al Frío Corticosterona Selection Responses Cold Stress Cold Tolerance Corticosterone Paramétros de Comportamiento |
| url | http://hdl.handle.net/20.500.12123/7628 https://www.sciencedirect.com/science/article/abs/pii/S027858461930497X https://doi.org/10.1016/j.pnpbp.2019.109726 |
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