Effect of dexamethasone in Neospora Caninum seropositive calves
The aim of this study was to evaluate the effect of Dexamethasone (DXM) on clinical parameters, absolute and differential leukocyte count, specific IgG titers, IFN-γ production and parasitemia in beef calves seropositive to Neospora caninum. Fifteen calves were assigned to four experimental groups a...
| Autores principales: | , , , , , , , , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
| Publicado: |
Multidisciplinary Digital Publishing Institute (MDPI)
2020
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/7460 http://kjclinicalmedicine.org/files/KJCM-1004.pdf |
| _version_ | 1855035862825304064 |
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| author | Idarraga Bedoya, Samuel Armendano, Joaquín Ignacio Gual, Ignacio Hecker, Yanina Leunda, Maria Rosa Pereyra, Susana Beatriz Verna, Andrea Elizabeth Campero, Carlos Manuel Odeon, Anselmo Carlos Moore, Prando Dadin |
| author_browse | Armendano, Joaquín Ignacio Campero, Carlos Manuel Gual, Ignacio Hecker, Yanina Idarraga Bedoya, Samuel Leunda, Maria Rosa Moore, Prando Dadin Odeon, Anselmo Carlos Pereyra, Susana Beatriz Verna, Andrea Elizabeth |
| author_facet | Idarraga Bedoya, Samuel Armendano, Joaquín Ignacio Gual, Ignacio Hecker, Yanina Leunda, Maria Rosa Pereyra, Susana Beatriz Verna, Andrea Elizabeth Campero, Carlos Manuel Odeon, Anselmo Carlos Moore, Prando Dadin |
| author_sort | Idarraga Bedoya, Samuel |
| collection | INTA Digital |
| description | The aim of this study was to evaluate the effect of Dexamethasone (DXM) on clinical parameters, absolute and differential leukocyte count, specific IgG titers, IFN-γ production and parasitemia in beef calves seropositive to Neospora caninum. Fifteen calves were assigned to four experimental groups as follow: group A: 4 sero- positive calves treated with DXM; group B: 4 seropositive calves without DXM; group C: 3 seronegative calves treated with DXM, and group D: 4 seronegative calves without DXM treatment. The absolute leukocyte count was higher in both groups A and C in the 3rd day after the first dose of DXM mainly due to a significant neutrophilia (p<0.05). No changes in the total specific IgG titers or ratios between their subisotypes or antibodies against NcGRA7 and NcSAG4 antigens were observed in calves from group A com- pared with those in group B (p>0.05). Similarly, IFN-γ levels did not change among experimental groups (p>0.05). DNA was de- tected in calves from groups A and B at 7 Days Post Administra- tion (dpa) and from group A at 14 dpa. Even when DXM adminis- tration induced hemotological parameter changes, no reactivation of Neospora-infection was observed according to specific IgG titers and presence of the parasite on leukocytes in naturally seropositive beef male calves. |
| format | info:ar-repo/semantics/artículo |
| id | INTA7460 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Multidisciplinary Digital Publishing Institute (MDPI) |
| publisherStr | Multidisciplinary Digital Publishing Institute (MDPI) |
| record_format | dspace |
| spelling | INTA74602020-06-23T16:52:21Z Effect of dexamethasone in Neospora Caninum seropositive calves Idarraga Bedoya, Samuel Armendano, Joaquín Ignacio Gual, Ignacio Hecker, Yanina Leunda, Maria Rosa Pereyra, Susana Beatriz Verna, Andrea Elizabeth Campero, Carlos Manuel Odeon, Anselmo Carlos Moore, Prando Dadin Ternero Dexametasona Neospora Caninum Inmunología Serología Enfermedades de los Animales Calves Dexamethasone Immunology Serology Animal Diseases The aim of this study was to evaluate the effect of Dexamethasone (DXM) on clinical parameters, absolute and differential leukocyte count, specific IgG titers, IFN-γ production and parasitemia in beef calves seropositive to Neospora caninum. Fifteen calves were assigned to four experimental groups as follow: group A: 4 sero- positive calves treated with DXM; group B: 4 seropositive calves without DXM; group C: 3 seronegative calves treated with DXM, and group D: 4 seronegative calves without DXM treatment. The absolute leukocyte count was higher in both groups A and C in the 3rd day after the first dose of DXM mainly due to a significant neutrophilia (p<0.05). No changes in the total specific IgG titers or ratios between their subisotypes or antibodies against NcGRA7 and NcSAG4 antigens were observed in calves from group A com- pared with those in group B (p>0.05). Similarly, IFN-γ levels did not change among experimental groups (p>0.05). DNA was de- tected in calves from groups A and B at 7 Days Post Administra- tion (dpa) and from group A at 14 dpa. Even when DXM adminis- tration induced hemotological parameter changes, no reactivation of Neospora-infection was observed according to specific IgG titers and presence of the parasite on leukocytes in naturally seropositive beef male calves. Fil: Idarraga-Bedoya Samuel. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina. Fil: Armendano Joaquin Ignacio. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina. Fil: Gual, Ignacio. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina. Fil: Hecker Yanina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fil: Leunda María Rosa. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Fil: Pereyra Susana. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Fil: Verna Andrea Elizabeth. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Fil: Campero Carlos Manuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Fil: Odeon Anselmo Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Fil: Moore Dadin Prando. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. 2020-06-23T16:28:47Z 2020-06-23T16:28:47Z 2020-03-09 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/7460 http://kjclinicalmedicine.org/files/KJCM-1004.pdf 2077-0383 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Multidisciplinary Digital Publishing Institute (MDPI) Korean Journal of Clinical Medicine 1 (1) : 1-6 (2020) |
| spellingShingle | Ternero Dexametasona Neospora Caninum Inmunología Serología Enfermedades de los Animales Calves Dexamethasone Immunology Serology Animal Diseases Idarraga Bedoya, Samuel Armendano, Joaquín Ignacio Gual, Ignacio Hecker, Yanina Leunda, Maria Rosa Pereyra, Susana Beatriz Verna, Andrea Elizabeth Campero, Carlos Manuel Odeon, Anselmo Carlos Moore, Prando Dadin Effect of dexamethasone in Neospora Caninum seropositive calves |
| title | Effect of dexamethasone in Neospora Caninum seropositive calves |
| title_full | Effect of dexamethasone in Neospora Caninum seropositive calves |
| title_fullStr | Effect of dexamethasone in Neospora Caninum seropositive calves |
| title_full_unstemmed | Effect of dexamethasone in Neospora Caninum seropositive calves |
| title_short | Effect of dexamethasone in Neospora Caninum seropositive calves |
| title_sort | effect of dexamethasone in neospora caninum seropositive calves |
| topic | Ternero Dexametasona Neospora Caninum Inmunología Serología Enfermedades de los Animales Calves Dexamethasone Immunology Serology Animal Diseases |
| url | http://hdl.handle.net/20.500.12123/7460 http://kjclinicalmedicine.org/files/KJCM-1004.pdf |
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