Vaccines against bovine babesiosis: where we are now and possible roads ahead
Bovine babesiosis caused by the tick-transmitted haemoprotozoans Babesia bovis, Babesia bigemina and Babesia divergens commonly results in substantial cattle morbidity and mortality in vast world areas. Although existing live vaccines confer protection, they have considerable disadvantages. Therefor...
| Autores principales: | , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
Cambridge University Press
2020
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| Acceso en línea: | http://hdl.handle.net/20.500.12123/6712 https://www.cambridge.org/core/journals/parasitology/article/vaccines-against-bovine-babesiosis-where-we-are-now-and-possible-roads-ahead/AB57CCC9D2E129C420762F66D7A3DF33 https://doi.org/10.1017/S0031182014000961 |
| _version_ | 1855483867270479872 |
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| author | Florin-Christensen, Mónica Suarez, Carlos Esteban Rodriguez, Anabel Elisa Flores, Daniela Schnittger, Leonhard |
| author_browse | Flores, Daniela Florin-Christensen, Mónica Rodriguez, Anabel Elisa Schnittger, Leonhard Suarez, Carlos Esteban |
| author_facet | Florin-Christensen, Mónica Suarez, Carlos Esteban Rodriguez, Anabel Elisa Flores, Daniela Schnittger, Leonhard |
| author_sort | Florin-Christensen, Mónica |
| collection | INTA Digital |
| description | Bovine babesiosis caused by the tick-transmitted haemoprotozoans Babesia bovis, Babesia bigemina and Babesia divergens commonly results in substantial cattle morbidity and mortality in vast world areas. Although existing live vaccines confer protection, they have considerable disadvantages. Therefore, particularly in countries where large numbers of cattle are at risk, important research is directed towards improved vaccination strategies. Here a comprehensive overview of currently used live vaccines and of the status quo of experimental vaccine trials is presented. In addition, pertinent research fields potentially contributing to the development of novel non-live and/or live vaccines are discussed, including parasite antigens involved in host cell invasion and in pathogen-tick interactions, as well as the protective immunity against infection. The mining of available parasite genomes is continuously enlarging the array of potential vaccine candidates and, additionally, the recent development of a transfection tool for Babesia can significantly contribute to vaccine design. However, the complication and high cost of vaccination trials hinder Babesia vaccine research, and have so far seriously limited the systematic examination of antigen candidates and prevented an in-depth testing of formulations using different immunomodulators and antigen delivery systems. |
| format | Artículo |
| id | INTA6712 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Cambridge University Press |
| publisherStr | Cambridge University Press |
| record_format | dspace |
| spelling | INTA67122020-02-11T11:17:58Z Vaccines against bovine babesiosis: where we are now and possible roads ahead Florin-Christensen, Mónica Suarez, Carlos Esteban Rodriguez, Anabel Elisa Flores, Daniela Schnittger, Leonhard Babesiosis Vacuna Viva Eritrocitos Enfermedades Transmitidas por Garrapatas Respuesta Inmunológica Ganado Bovino Live Vaccines Erythrocytes Tick-borne Diseases Immune Response Cattle Bovine babesiosis caused by the tick-transmitted haemoprotozoans Babesia bovis, Babesia bigemina and Babesia divergens commonly results in substantial cattle morbidity and mortality in vast world areas. Although existing live vaccines confer protection, they have considerable disadvantages. Therefore, particularly in countries where large numbers of cattle are at risk, important research is directed towards improved vaccination strategies. Here a comprehensive overview of currently used live vaccines and of the status quo of experimental vaccine trials is presented. In addition, pertinent research fields potentially contributing to the development of novel non-live and/or live vaccines are discussed, including parasite antigens involved in host cell invasion and in pathogen-tick interactions, as well as the protective immunity against infection. The mining of available parasite genomes is continuously enlarging the array of potential vaccine candidates and, additionally, the recent development of a transfection tool for Babesia can significantly contribute to vaccine design. However, the complication and high cost of vaccination trials hinder Babesia vaccine research, and have so far seriously limited the systematic examination of antigen candidates and prevented an in-depth testing of formulations using different immunomodulators and antigen delivery systems. Instituto de Patobiología Fil: Florin-Christensen, Monica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Suarez, Carlos Esteban. Washington State University. Department of Veterinary Microbiology and Pathology; Estados Unidos Fil: Rodriguez, Anabel Elisa. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina Fil: Flores, Daniela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. ANPCyT; Argentina Fil: Schnittger, Leonhard. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2020-02-11T11:08:24Z 2020-02-11T11:08:24Z 2014-10 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/6712 https://www.cambridge.org/core/journals/parasitology/article/vaccines-against-bovine-babesiosis-where-we-are-now-and-possible-roads-ahead/AB57CCC9D2E129C420762F66D7A3DF33 1469-8161 https://doi.org/10.1017/S0031182014000961 eng info:eu-repo/semantics/restrictedAccess application/pdf Cambridge University Press Parasitology 141 (12) : 1563-1592 (Octubre 2014) |
| spellingShingle | Babesiosis Vacuna Viva Eritrocitos Enfermedades Transmitidas por Garrapatas Respuesta Inmunológica Ganado Bovino Live Vaccines Erythrocytes Tick-borne Diseases Immune Response Cattle Florin-Christensen, Mónica Suarez, Carlos Esteban Rodriguez, Anabel Elisa Flores, Daniela Schnittger, Leonhard Vaccines against bovine babesiosis: where we are now and possible roads ahead |
| title | Vaccines against bovine babesiosis: where we are now and possible roads ahead |
| title_full | Vaccines against bovine babesiosis: where we are now and possible roads ahead |
| title_fullStr | Vaccines against bovine babesiosis: where we are now and possible roads ahead |
| title_full_unstemmed | Vaccines against bovine babesiosis: where we are now and possible roads ahead |
| title_short | Vaccines against bovine babesiosis: where we are now and possible roads ahead |
| title_sort | vaccines against bovine babesiosis where we are now and possible roads ahead |
| topic | Babesiosis Vacuna Viva Eritrocitos Enfermedades Transmitidas por Garrapatas Respuesta Inmunológica Ganado Bovino Live Vaccines Erythrocytes Tick-borne Diseases Immune Response Cattle |
| url | http://hdl.handle.net/20.500.12123/6712 https://www.cambridge.org/core/journals/parasitology/article/vaccines-against-bovine-babesiosis-where-we-are-now-and-possible-roads-ahead/AB57CCC9D2E129C420762F66D7A3DF33 https://doi.org/10.1017/S0031182014000961 |
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