Understanding the intracellular-to-extracellular localization switch of polyhydroxybutyrate polymerase in pseudomonas backgrounds as a microevolutionary process
After gene duplication, paralogous genes evolve independently, and consequently, the new proteins encoded by these duplicated genes are exposed to changes in their subcellular location. Although there are increasing evidence that phylogenetically related proteins play different functions in differen...
| Autores principales: | , , , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/6701 https://www.sciencedirect.com/science/article/pii/S0022519318303680 https://doi.org/10.1016/j.jtbi.2018.07.039 |
| _version_ | 1855035722965188608 |
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| author | Stritzler, Margarita Berini, Carolina Andrea Jozefkowicz, Cintia Soto, Gabriela Cinthia Ayub, Nicolás Daniel |
| author_browse | Ayub, Nicolás Daniel Berini, Carolina Andrea Jozefkowicz, Cintia Soto, Gabriela Cinthia Stritzler, Margarita |
| author_facet | Stritzler, Margarita Berini, Carolina Andrea Jozefkowicz, Cintia Soto, Gabriela Cinthia Ayub, Nicolás Daniel |
| author_sort | Stritzler, Margarita |
| collection | INTA Digital |
| description | After gene duplication, paralogous genes evolve independently, and consequently, the new proteins encoded by these duplicated genes are exposed to changes in their subcellular location. Although there are increasing evidence that phylogenetically related proteins play different functions in different subcellular compartments, the number of evolutionary steps required for the emergence of a novel protein with a novel subcellular localization remains unclear. Regarding this intriguing topic, here we examine in depth our previous reports describing both intracellular and extracellular polyhydroxybutyrate polymerases (PhaC) in the Pseudomonadales group. The recapitulation of the intracellular-to-extracellular localization switch of PhaC in these strains shows a gradual evolution from a simple cytosolic PhaC form to a complex extracellular PhaC form specifically secreted via the type 1 secretion system. This gradual evolution includes several adaptive and pre-adaptive changes at the genomic, genetic and enzymatic levels, which are intimately related to the lifestyle of organisms during the evolution of protein localization. We conclude that the protein localization switch can be an extremely complex process in nature. |
| format | info:ar-repo/semantics/artículo |
| id | INTA6701 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA67012020-02-10T13:39:26Z Understanding the intracellular-to-extracellular localization switch of polyhydroxybutyrate polymerase in pseudomonas backgrounds as a microevolutionary process Stritzler, Margarita Berini, Carolina Andrea Jozefkowicz, Cintia Soto, Gabriela Cinthia Ayub, Nicolás Daniel Pseudomonas Evolución Evolution Microevolution Microevolución Polyhydroxybutyrate polymerase After gene duplication, paralogous genes evolve independently, and consequently, the new proteins encoded by these duplicated genes are exposed to changes in their subcellular location. Although there are increasing evidence that phylogenetically related proteins play different functions in different subcellular compartments, the number of evolutionary steps required for the emergence of a novel protein with a novel subcellular localization remains unclear. Regarding this intriguing topic, here we examine in depth our previous reports describing both intracellular and extracellular polyhydroxybutyrate polymerases (PhaC) in the Pseudomonadales group. The recapitulation of the intracellular-to-extracellular localization switch of PhaC in these strains shows a gradual evolution from a simple cytosolic PhaC form to a complex extracellular PhaC form specifically secreted via the type 1 secretion system. This gradual evolution includes several adaptive and pre-adaptive changes at the genomic, genetic and enzymatic levels, which are intimately related to the lifestyle of organisms during the evolution of protein localization. We conclude that the protein localization switch can be an extremely complex process in nature. Instituto de Genética Fil: Stritzler, Margarita. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Berini, Carolina Andrea. Instituto de Investigaciones Biomédicas en Retrovirus y SIDA; Argentina Fil: Jozefkowicz, Cintia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Soto, Gabriela Cinthia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Ayub, Nicolás Daniel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2020-02-10T13:29:38Z 2020-02-10T13:29:38Z 2018-11 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/6701 https://www.sciencedirect.com/science/article/pii/S0022519318303680 1095-8541 https://doi.org/10.1016/j.jtbi.2018.07.039 eng info:eu-repo/semantics/restrictedAccess application/pdf Elsevier Journal of Theoretical Biology 456 : 29-33 (Noviembre 2018) |
| spellingShingle | Pseudomonas Evolución Evolution Microevolution Microevolución Polyhydroxybutyrate polymerase Stritzler, Margarita Berini, Carolina Andrea Jozefkowicz, Cintia Soto, Gabriela Cinthia Ayub, Nicolás Daniel Understanding the intracellular-to-extracellular localization switch of polyhydroxybutyrate polymerase in pseudomonas backgrounds as a microevolutionary process |
| title | Understanding the intracellular-to-extracellular localization switch of polyhydroxybutyrate polymerase in pseudomonas backgrounds as a microevolutionary process |
| title_full | Understanding the intracellular-to-extracellular localization switch of polyhydroxybutyrate polymerase in pseudomonas backgrounds as a microevolutionary process |
| title_fullStr | Understanding the intracellular-to-extracellular localization switch of polyhydroxybutyrate polymerase in pseudomonas backgrounds as a microevolutionary process |
| title_full_unstemmed | Understanding the intracellular-to-extracellular localization switch of polyhydroxybutyrate polymerase in pseudomonas backgrounds as a microevolutionary process |
| title_short | Understanding the intracellular-to-extracellular localization switch of polyhydroxybutyrate polymerase in pseudomonas backgrounds as a microevolutionary process |
| title_sort | understanding the intracellular to extracellular localization switch of polyhydroxybutyrate polymerase in pseudomonas backgrounds as a microevolutionary process |
| topic | Pseudomonas Evolución Evolution Microevolution Microevolución Polyhydroxybutyrate polymerase |
| url | http://hdl.handle.net/20.500.12123/6701 https://www.sciencedirect.com/science/article/pii/S0022519318303680 https://doi.org/10.1016/j.jtbi.2018.07.039 |
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