Immune cells transferred by colostrum do not influence the immune responses to foot-and-mouth disease primary vaccination
Little is known about the influence of maternal antibodies and immune cells transferred through colostrum on the immune responses of calves to the currently used foot-and-mouth disease (FMD) vaccines. Here we evaluated the humoral and cellular immune responses induced by vaccination of colostrum-dep...
| Autores principales: | , , , , , , , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
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Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.journalofdairyscience.org/article/S0022-0302(19)30584-3/fulltext http://hdl.handle.net/20.500.12123/6336 https://doi.org/10.3168/jds.2018-15781 |
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| author | Bucafusco, Danilo Pereyra, Walter Rodrigo Mansilla, Florencia Celeste Malacari, Darío Amilcar Juncos, María S. Di Giacomo, Sebastián Ayude, Andrea Fabiana Perez Filgueira, Daniel Mariano Capozzo, Alejandra Victoria |
| author_browse | Ayude, Andrea Fabiana Bucafusco, Danilo Capozzo, Alejandra Victoria Di Giacomo, Sebastián Juncos, María S. Malacari, Darío Amilcar Mansilla, Florencia Celeste Pereyra, Walter Rodrigo Perez Filgueira, Daniel Mariano |
| author_facet | Bucafusco, Danilo Pereyra, Walter Rodrigo Mansilla, Florencia Celeste Malacari, Darío Amilcar Juncos, María S. Di Giacomo, Sebastián Ayude, Andrea Fabiana Perez Filgueira, Daniel Mariano Capozzo, Alejandra Victoria |
| author_sort | Bucafusco, Danilo |
| collection | INTA Digital |
| description | Little is known about the influence of maternal antibodies and immune cells transferred through colostrum on the immune responses of calves to the currently used foot-and-mouth disease (FMD) vaccines. Here we evaluated the humoral and cellular immune responses induced by vaccination of colostrum-deprived calves and calves that received equivalent amounts of colostrum preparations that differed in the presence or absence of maternal immune cells but contained the same quantity and quality of anti-foot-and-mouth disease virus (FMDV) antibodies. Three groups of 32-d-old calves (n = 3 per group) were deprived of colostrum and fed either whole immune colostrum or a cell-free colostrum preparation containing only anti-FMDV antibodies. All groups were immunized with 1 dose of an oil-adjuvanted commercial vaccine. Blood samples were collected periodically before vaccination and weekly after vaccination. Immune responses specific to FMDV were assessed based on T-cell proliferation, IFN-γ production, total and neutralizing serum antibodies, and isotype profile. All vaccinated calves developed IFN-γ and lymphoproliferative responses, irrespective of the colostrum received. Colostrum-deprived animals responded to vaccination with a primary IgM response followed by an increase of IgG1 titers. Conversely, antibody titers decreased in all colostrum-fed calves after vaccination. This study demonstrates for the first time that maternal immune cells transferred to the calves through colostrum do not modify immune responses to FMD vaccine, and it confirms the interference of maternal antibodies in the induction of humoral but not cell-mediated immune responses. |
| format | info:ar-repo/semantics/artículo |
| id | INTA6336 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA63362019-11-19T17:37:09Z Immune cells transferred by colostrum do not influence the immune responses to foot-and-mouth disease primary vaccination Bucafusco, Danilo Pereyra, Walter Rodrigo Mansilla, Florencia Celeste Malacari, Darío Amilcar Juncos, María S. Di Giacomo, Sebastián Ayude, Andrea Fabiana Perez Filgueira, Daniel Mariano Capozzo, Alejandra Victoria Foot and Mouth Disease Vaccines Maternal Immunity Calves Colostrum Immune Response Fiebre Aftosa Vacuna Inmunidad Maternal Ternero Calostro Respuesta Inmunológica Little is known about the influence of maternal antibodies and immune cells transferred through colostrum on the immune responses of calves to the currently used foot-and-mouth disease (FMD) vaccines. Here we evaluated the humoral and cellular immune responses induced by vaccination of colostrum-deprived calves and calves that received equivalent amounts of colostrum preparations that differed in the presence or absence of maternal immune cells but contained the same quantity and quality of anti-foot-and-mouth disease virus (FMDV) antibodies. Three groups of 32-d-old calves (n = 3 per group) were deprived of colostrum and fed either whole immune colostrum or a cell-free colostrum preparation containing only anti-FMDV antibodies. All groups were immunized with 1 dose of an oil-adjuvanted commercial vaccine. Blood samples were collected periodically before vaccination and weekly after vaccination. Immune responses specific to FMDV were assessed based on T-cell proliferation, IFN-γ production, total and neutralizing serum antibodies, and isotype profile. All vaccinated calves developed IFN-γ and lymphoproliferative responses, irrespective of the colostrum received. Colostrum-deprived animals responded to vaccination with a primary IgM response followed by an increase of IgG1 titers. Conversely, antibody titers decreased in all colostrum-fed calves after vaccination. This study demonstrates for the first time that maternal immune cells transferred to the calves through colostrum do not modify immune responses to FMD vaccine, and it confirms the interference of maternal antibodies in the induction of humoral but not cell-mediated immune responses. Instituto de Virología Fil: Bucafusco, Danilo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Pereyra, Walter Rodrigo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Cerrillos; Argentina Fil: Mansilla, Florencia Celeste. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Malacari, Darío Amilcar. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Juncos, María S. Veterinaria independiente; Argentina Fil: Di Giacomo, Sebastián. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Ayude, Andrea Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Perez Filgueira, Daniel Mariano. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Capozzo, Alejandra Victoria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2019-11-19T17:30:17Z 2019-11-19T17:30:17Z 2019-09 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.journalofdairyscience.org/article/S0022-0302(19)30584-3/fulltext http://hdl.handle.net/20.500.12123/6336 0022-0302 https://doi.org/10.3168/jds.2018-15781 eng info:eu-repo/semantics/restrictedAccess application/pdf Elsevier Journal of dairy science 102 (9) : 8376-8384. (Septiembre 2019) |
| spellingShingle | Foot and Mouth Disease Vaccines Maternal Immunity Calves Colostrum Immune Response Fiebre Aftosa Vacuna Inmunidad Maternal Ternero Calostro Respuesta Inmunológica Bucafusco, Danilo Pereyra, Walter Rodrigo Mansilla, Florencia Celeste Malacari, Darío Amilcar Juncos, María S. Di Giacomo, Sebastián Ayude, Andrea Fabiana Perez Filgueira, Daniel Mariano Capozzo, Alejandra Victoria Immune cells transferred by colostrum do not influence the immune responses to foot-and-mouth disease primary vaccination |
| title | Immune cells transferred by colostrum do not influence the immune responses to foot-and-mouth disease primary vaccination |
| title_full | Immune cells transferred by colostrum do not influence the immune responses to foot-and-mouth disease primary vaccination |
| title_fullStr | Immune cells transferred by colostrum do not influence the immune responses to foot-and-mouth disease primary vaccination |
| title_full_unstemmed | Immune cells transferred by colostrum do not influence the immune responses to foot-and-mouth disease primary vaccination |
| title_short | Immune cells transferred by colostrum do not influence the immune responses to foot-and-mouth disease primary vaccination |
| title_sort | immune cells transferred by colostrum do not influence the immune responses to foot and mouth disease primary vaccination |
| topic | Foot and Mouth Disease Vaccines Maternal Immunity Calves Colostrum Immune Response Fiebre Aftosa Vacuna Inmunidad Maternal Ternero Calostro Respuesta Inmunológica |
| url | https://www.journalofdairyscience.org/article/S0022-0302(19)30584-3/fulltext http://hdl.handle.net/20.500.12123/6336 https://doi.org/10.3168/jds.2018-15781 |
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