Immune mediators of pathology in neurobrucellosis: from blood to central nervous system
Neurobrucellosis, which is the most morbid form of brucellosis disease, presents with inflammatory signs and symptoms. Recent experimental evidence clearly indicates that deregulation of astrocytes and microglia caused by Brucella infection creates a microenvironment in the central nervous system (C...
| Autores principales: | , , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/6331 https://www.sciencedirect.com/science/article/pii/S0306452219303343 https://doi.org/10.1016/j.neuroscience.2019.05.018 |
| _version_ | 1855035656142585856 |
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| author | Rodriguez, Ana María Delpino, María Victoria Miraglia, Maria Cruz Giambartolomei, Guillermo Hernán |
| author_browse | Delpino, María Victoria Giambartolomei, Guillermo Hernán Miraglia, Maria Cruz Rodriguez, Ana María |
| author_facet | Rodriguez, Ana María Delpino, María Victoria Miraglia, Maria Cruz Giambartolomei, Guillermo Hernán |
| author_sort | Rodriguez, Ana María |
| collection | INTA Digital |
| description | Neurobrucellosis, which is the most morbid form of brucellosis disease, presents with inflammatory signs and symptoms. Recent experimental evidence clearly indicates that deregulation of astrocytes and microglia caused by Brucella infection creates a microenvironment in the central nervous system (CNS) in which secretion of pro-inflammatory mediators lead to destabilization of the glial structure, the damage of the blood brain barrier (BBB) and neuronal demise. This review of Brucella interactions with cells of the CNS and the BBB is intended to present recent immunological findings that can explain, at least in part, the basis for the inflammatory pathogenesis of the nervous system that takes place upon Brucella infection. |
| format | info:ar-repo/semantics/artículo |
| id | INTA6331 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA63312025-09-08T10:16:05Z Immune mediators of pathology in neurobrucellosis: from blood to central nervous system Rodriguez, Ana María Delpino, María Victoria Miraglia, Maria Cruz Giambartolomei, Guillermo Hernán Brucellosis Central Nervous System Pathogenesis Immunology Nervous System Diseases Brucelosis Sistema Nervioso Central Patogénesis Inmunología Trastornos del Sistema Nervioso Neurobrucellosis, which is the most morbid form of brucellosis disease, presents with inflammatory signs and symptoms. Recent experimental evidence clearly indicates that deregulation of astrocytes and microglia caused by Brucella infection creates a microenvironment in the central nervous system (CNS) in which secretion of pro-inflammatory mediators lead to destabilization of the glial structure, the damage of the blood brain barrier (BBB) and neuronal demise. This review of Brucella interactions with cells of the CNS and the BBB is intended to present recent immunological findings that can explain, at least in part, the basis for the inflammatory pathogenesis of the nervous system that takes place upon Brucella infection. Instituto de Virología Fil: Rodriguez, Ana María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Inmunología, Genética y Metabolismo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Delpino, María Victoria. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Inmunología, Genética y Metabolismo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Miraglia, María Cruz. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Giambartolomei, Guillermo Hernán. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Inmunología, Genética y Metabolismo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2019-11-19T13:46:04Z 2019-11-19T13:46:04Z 2019-07 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/6331 https://www.sciencedirect.com/science/article/pii/S0306452219303343 0306-4522 https://doi.org/10.1016/j.neuroscience.2019.05.018 eng info:eu-repo/semantics/restrictedAccess application/pdf Elsevier Neuroscience 410 : 264-273 (2019) |
| spellingShingle | Brucellosis Central Nervous System Pathogenesis Immunology Nervous System Diseases Brucelosis Sistema Nervioso Central Patogénesis Inmunología Trastornos del Sistema Nervioso Rodriguez, Ana María Delpino, María Victoria Miraglia, Maria Cruz Giambartolomei, Guillermo Hernán Immune mediators of pathology in neurobrucellosis: from blood to central nervous system |
| title | Immune mediators of pathology in neurobrucellosis: from blood to central nervous system |
| title_full | Immune mediators of pathology in neurobrucellosis: from blood to central nervous system |
| title_fullStr | Immune mediators of pathology in neurobrucellosis: from blood to central nervous system |
| title_full_unstemmed | Immune mediators of pathology in neurobrucellosis: from blood to central nervous system |
| title_short | Immune mediators of pathology in neurobrucellosis: from blood to central nervous system |
| title_sort | immune mediators of pathology in neurobrucellosis from blood to central nervous system |
| topic | Brucellosis Central Nervous System Pathogenesis Immunology Nervous System Diseases Brucelosis Sistema Nervioso Central Patogénesis Inmunología Trastornos del Sistema Nervioso |
| url | http://hdl.handle.net/20.500.12123/6331 https://www.sciencedirect.com/science/article/pii/S0306452219303343 https://doi.org/10.1016/j.neuroscience.2019.05.018 |
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