BLV: lessons on vaccine development
Vaccination against retroviruses is a challenge because of their ability to stably integrate into the host genome, undergo long-term latency in a proportion of infected cells and thereby escape immune response. Since clearance of the virus is almost impossible once infection is established, the prim...
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| Format: | info:ar-repo/semantics/artículo |
| Language: | Inglés |
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BMC
2019
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| Online Access: | https://retrovirology.biomedcentral.com/articles/10.1186/s12977-019-0488-8 http://hdl.handle.net/20.500.12123/6118 https://doi.org/10.1186/s12977-019-0488-8 |
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| author | Abdala, Alejandro Ariel Alvarez, Irene Brossel, Hélène Calvinho, Luis Fernando Carignano, Hugo Franco, Lautaro Nahuel Gazon, Hélène Gillissen, Christelle Hamaidia, Malik Hoyos, Clotilde Jacques, Jean-Rock Joris, Thomas Laval, Florent Petersen, Marcos Iván Porquet, Florent Porta, Natalia Gabriela Ruiz, Vanesa Safari, Rogaiyeh Suarez Archilla, Guillermo Alejandro Trono, Karina Gabriela Willems, Luc |
| author_browse | Abdala, Alejandro Ariel Alvarez, Irene Brossel, Hélène Calvinho, Luis Fernando Carignano, Hugo Franco, Lautaro Nahuel Gazon, Hélène Gillissen, Christelle Hamaidia, Malik Hoyos, Clotilde Jacques, Jean-Rock Joris, Thomas Laval, Florent Petersen, Marcos Iván Porquet, Florent Porta, Natalia Gabriela Ruiz, Vanesa Safari, Rogaiyeh Suarez Archilla, Guillermo Alejandro Trono, Karina Gabriela Willems, Luc |
| author_facet | Abdala, Alejandro Ariel Alvarez, Irene Brossel, Hélène Calvinho, Luis Fernando Carignano, Hugo Franco, Lautaro Nahuel Gazon, Hélène Gillissen, Christelle Hamaidia, Malik Hoyos, Clotilde Jacques, Jean-Rock Joris, Thomas Laval, Florent Petersen, Marcos Iván Porquet, Florent Porta, Natalia Gabriela Ruiz, Vanesa Safari, Rogaiyeh Suarez Archilla, Guillermo Alejandro Trono, Karina Gabriela Willems, Luc |
| author_sort | Abdala, Alejandro Ariel |
| collection | INTA Digital |
| description | Vaccination against retroviruses is a challenge because of their ability to stably integrate into the host genome, undergo long-term latency in a proportion of infected cells and thereby escape immune response. Since clearance of the virus is almost impossible once infection is established, the primary goal is to achieve sterilizing immunity. Besides efficacy, safety is the major issue since vaccination has been associated with increased infection or reversion to pathogenicity. In this review, we discuss the different issues that we faced during the development of an efficient vaccine against bovine leukemia virus (BLV). We summarize the historical failures of inactivated vaccines, the efficacy and safety of a live-attenuated vaccine and the economical constraints of further industrial development. |
| format | info:ar-repo/semantics/artículo |
| id | INTA6118 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | BMC |
| publisherStr | BMC |
| record_format | dspace |
| spelling | INTA61182019-10-16T11:44:57Z BLV: lessons on vaccine development Abdala, Alejandro Ariel Alvarez, Irene Brossel, Hélène Calvinho, Luis Fernando Carignano, Hugo Franco, Lautaro Nahuel Gazon, Hélène Gillissen, Christelle Hamaidia, Malik Hoyos, Clotilde Jacques, Jean-Rock Joris, Thomas Laval, Florent Petersen, Marcos Iván Porquet, Florent Porta, Natalia Gabriela Ruiz, Vanesa Safari, Rogaiyeh Suarez Archilla, Guillermo Alejandro Trono, Karina Gabriela Willems, Luc Vacuna Vacunación Retroviridae Virus Leucemia Bovina Vaccines Vaccination Bovine Leukaemia Virus Vaccination against retroviruses is a challenge because of their ability to stably integrate into the host genome, undergo long-term latency in a proportion of infected cells and thereby escape immune response. Since clearance of the virus is almost impossible once infection is established, the primary goal is to achieve sterilizing immunity. Besides efficacy, safety is the major issue since vaccination has been associated with increased infection or reversion to pathogenicity. In this review, we discuss the different issues that we faced during the development of an efficient vaccine against bovine leukemia virus (BLV). We summarize the historical failures of inactivated vaccines, the efficacy and safety of a live-attenuated vaccine and the economical constraints of further industrial development. EEA Rafaela Fil: Abdala, Alejandro Ariel. INTA. Estación Experimental Agropecuaria Rafaela; Argentina Fil: Alvarez, Irene. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Brossel, Hélène. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica Fil: Calvinho, Luis Fernando. INTA. Estación Experimental Agropecuaria Rafaela; Argentina Fil: Carignano, Hugo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina Fil: Franco, Lautaro. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina Fil: Gazon, Hélène. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica Fil: Gillissen, Christelle. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica Fil: Hoyos, Clotilde. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica Fil: Jacques, Jean-Rock. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica Fil: Joris, Thomas. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica Fil: Laval, Florent. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica Fil: Petersen, Marcos Iván. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina Fil: Porquet, Florent. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica Fil: Porta, Natalia Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina Fil: Ruiz, Vanesa. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina Fil: Safari, Rogaiyeh. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica Fil: Suarez Archilla, Guillermo Alejandro. INTA. Estación Experimental Agropecuaria Rafaela; Argentina Fil: Trono, Karina Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Willems, Luc. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica 2019-10-16T11:40:42Z 2019-10-16T11:40:42Z 2019-10-07 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://retrovirology.biomedcentral.com/articles/10.1186/s12977-019-0488-8 http://hdl.handle.net/20.500.12123/6118 1742-4690 https://doi.org/10.1186/s12977-019-0488-8 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf BMC Retrovirology 16 : article number: 26 (2019) |
| spellingShingle | Vacuna Vacunación Retroviridae Virus Leucemia Bovina Vaccines Vaccination Bovine Leukaemia Virus Abdala, Alejandro Ariel Alvarez, Irene Brossel, Hélène Calvinho, Luis Fernando Carignano, Hugo Franco, Lautaro Nahuel Gazon, Hélène Gillissen, Christelle Hamaidia, Malik Hoyos, Clotilde Jacques, Jean-Rock Joris, Thomas Laval, Florent Petersen, Marcos Iván Porquet, Florent Porta, Natalia Gabriela Ruiz, Vanesa Safari, Rogaiyeh Suarez Archilla, Guillermo Alejandro Trono, Karina Gabriela Willems, Luc BLV: lessons on vaccine development |
| title | BLV: lessons on vaccine development |
| title_full | BLV: lessons on vaccine development |
| title_fullStr | BLV: lessons on vaccine development |
| title_full_unstemmed | BLV: lessons on vaccine development |
| title_short | BLV: lessons on vaccine development |
| title_sort | blv lessons on vaccine development |
| topic | Vacuna Vacunación Retroviridae Virus Leucemia Bovina Vaccines Vaccination Bovine Leukaemia Virus |
| url | https://retrovirology.biomedcentral.com/articles/10.1186/s12977-019-0488-8 http://hdl.handle.net/20.500.12123/6118 https://doi.org/10.1186/s12977-019-0488-8 |
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