Effects of chronic Staphylococcus aureus infection on immunological parameters and functionality of macrophages isolated from bovine mammary secretions
The aim of this study was to characterize the effects of chronic S. aureus intramammary infection (IMI) on local innate and adaptive immune response during active involution. Cows in late lactation that were either uninfected or with chronic naturally acquired S. aureus IMI were included in this stu...
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2019
|
| Materias: | |
| Acceso en línea: | https://www.sciencedirect.com/science/article/pii/S0882401019308952 http://hdl.handle.net/20.500.12123/5933 https://doi.org/10.1016/j.micpath.2019.103743 |
| _version_ | 1855035584070811648 |
|---|---|
| author | Renna, María Sol Silvestrini, Paula Beccaria, Camila Velázquez, Natalia S. Baravalle, Celina Engler, Carolina Pereyra, Elizabet Amanda Lorena Calvinho, Luis Fernando Dallard, Bibiana Elisabet |
| author_browse | Baravalle, Celina Beccaria, Camila Calvinho, Luis Fernando Dallard, Bibiana Elisabet Engler, Carolina Pereyra, Elizabet Amanda Lorena Renna, María Sol Silvestrini, Paula Velázquez, Natalia S. |
| author_facet | Renna, María Sol Silvestrini, Paula Beccaria, Camila Velázquez, Natalia S. Baravalle, Celina Engler, Carolina Pereyra, Elizabet Amanda Lorena Calvinho, Luis Fernando Dallard, Bibiana Elisabet |
| author_sort | Renna, María Sol |
| collection | INTA Digital |
| description | The aim of this study was to characterize the effects of chronic S. aureus intramammary infection (IMI) on local innate and adaptive immune response during active involution. Cows in late lactation that were either uninfected or with chronic naturally acquired S. aureus IMI were included in this study. The levels of interleukin (IL)-1β, IL-6 and IL-4 were significantly higher in mammary secretions of S. aureus-infected quarters compared with uninfected at d 7, 14 and 21 of involution. Lactoferrin (Lf), total IgG and S. aureus specific IgG1 levels were significantly lower in mammary secretions of infected quarters compared with uninfected during the first three weeks of involution. The amount of intracellular reactive oxygen species (ROS) produced per macrophage, was significantly higher in mammary secretions of infected quarters compared with uninfected at d 14 post drying off. Nitrite production was significantly higher in phagocytes from infected mammary secretions compared with uninfected at d 7 and 14 post drying off. Chronic S. aureus IMI altered normal secretion composition during bovine mammary gland involution. The high IL-1β and IL-6 levels and increased functionality of macrophages in mammary secretions of infected quarters could be a result of the chronic inflammatory environment triggered by the presence of viable bacteria in mammary tissue. The lower levels of total and S. aureus specific antibodies and other immune factors in mammary secretion during this period may reduce the natural defense potential of the gland contributing to S. aureus persistence. |
| format | info:ar-repo/semantics/artículo |
| id | INTA5933 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA59332019-09-20T14:16:08Z Effects of chronic Staphylococcus aureus infection on immunological parameters and functionality of macrophages isolated from bovine mammary secretions Renna, María Sol Silvestrini, Paula Beccaria, Camila Velázquez, Natalia S. Baravalle, Celina Engler, Carolina Pereyra, Elizabet Amanda Lorena Calvinho, Luis Fernando Dallard, Bibiana Elisabet Staphylococcus aureus Ganado Bovino Glándulas Mamarias Respuesta Inmunológica Macrofagos Mastítis Bovina Cattle Mammary Glands Immune Response Macrophages Bovine Mastitis The aim of this study was to characterize the effects of chronic S. aureus intramammary infection (IMI) on local innate and adaptive immune response during active involution. Cows in late lactation that were either uninfected or with chronic naturally acquired S. aureus IMI were included in this study. The levels of interleukin (IL)-1β, IL-6 and IL-4 were significantly higher in mammary secretions of S. aureus-infected quarters compared with uninfected at d 7, 14 and 21 of involution. Lactoferrin (Lf), total IgG and S. aureus specific IgG1 levels were significantly lower in mammary secretions of infected quarters compared with uninfected during the first three weeks of involution. The amount of intracellular reactive oxygen species (ROS) produced per macrophage, was significantly higher in mammary secretions of infected quarters compared with uninfected at d 14 post drying off. Nitrite production was significantly higher in phagocytes from infected mammary secretions compared with uninfected at d 7 and 14 post drying off. Chronic S. aureus IMI altered normal secretion composition during bovine mammary gland involution. The high IL-1β and IL-6 levels and increased functionality of macrophages in mammary secretions of infected quarters could be a result of the chronic inflammatory environment triggered by the presence of viable bacteria in mammary tissue. The lower levels of total and S. aureus specific antibodies and other immune factors in mammary secretion during this period may reduce the natural defense potential of the gland contributing to S. aureus persistence. EEA Rafaela Fil: Renna, María Sol. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Laboratorio de Biología Celular y Molecular Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina Fil: Silvestrini, Paula. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Laboratorio de Biología Celular y Molecular Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina Fil: Beccaría, Camila. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Laboratorio de Biología Celular y Molecular Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina Fil: Velázquez, Natalia S. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Laboratorio de Biología Celular y Molecular Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina Fil: Baravalle, Celina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Laboratorio de Biología Celular y Molecular Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina Fil: Engler, Carolina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Laboratorio de Biología Celular y Molecular Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina Fil: Pereyra, Elizabet Amanda Lorena. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Laboratorio de Biología Celular y Molecular Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina Fil: Calvinho, Luis Fernando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina Fil: Dallard, Bibiana Elisabet. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Laboratorio de Biología Celular y Molecular Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina 2019-09-20T14:14:13Z 2019-09-20T14:14:13Z 2019-09 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.sciencedirect.com/science/article/pii/S0882401019308952 http://hdl.handle.net/20.500.12123/5933 0882-4010 https://doi.org/10.1016/j.micpath.2019.103743 eng info:eu-repo/semantics/restrictedAccess application/pdf Elsevier Microbial Pathogenesis 137 : 103743 (December 2019) |
| spellingShingle | Staphylococcus aureus Ganado Bovino Glándulas Mamarias Respuesta Inmunológica Macrofagos Mastítis Bovina Cattle Mammary Glands Immune Response Macrophages Bovine Mastitis Renna, María Sol Silvestrini, Paula Beccaria, Camila Velázquez, Natalia S. Baravalle, Celina Engler, Carolina Pereyra, Elizabet Amanda Lorena Calvinho, Luis Fernando Dallard, Bibiana Elisabet Effects of chronic Staphylococcus aureus infection on immunological parameters and functionality of macrophages isolated from bovine mammary secretions |
| title | Effects of chronic Staphylococcus aureus infection on immunological parameters and functionality of macrophages isolated from bovine mammary secretions |
| title_full | Effects of chronic Staphylococcus aureus infection on immunological parameters and functionality of macrophages isolated from bovine mammary secretions |
| title_fullStr | Effects of chronic Staphylococcus aureus infection on immunological parameters and functionality of macrophages isolated from bovine mammary secretions |
| title_full_unstemmed | Effects of chronic Staphylococcus aureus infection on immunological parameters and functionality of macrophages isolated from bovine mammary secretions |
| title_short | Effects of chronic Staphylococcus aureus infection on immunological parameters and functionality of macrophages isolated from bovine mammary secretions |
| title_sort | effects of chronic staphylococcus aureus infection on immunological parameters and functionality of macrophages isolated from bovine mammary secretions |
| topic | Staphylococcus aureus Ganado Bovino Glándulas Mamarias Respuesta Inmunológica Macrofagos Mastítis Bovina Cattle Mammary Glands Immune Response Macrophages Bovine Mastitis |
| url | https://www.sciencedirect.com/science/article/pii/S0882401019308952 http://hdl.handle.net/20.500.12123/5933 https://doi.org/10.1016/j.micpath.2019.103743 |
| work_keys_str_mv | AT rennamariasol effectsofchronicstaphylococcusaureusinfectiononimmunologicalparametersandfunctionalityofmacrophagesisolatedfrombovinemammarysecretions AT silvestrinipaula effectsofchronicstaphylococcusaureusinfectiononimmunologicalparametersandfunctionalityofmacrophagesisolatedfrombovinemammarysecretions AT beccariacamila effectsofchronicstaphylococcusaureusinfectiononimmunologicalparametersandfunctionalityofmacrophagesisolatedfrombovinemammarysecretions AT velazqueznatalias effectsofchronicstaphylococcusaureusinfectiononimmunologicalparametersandfunctionalityofmacrophagesisolatedfrombovinemammarysecretions AT baravallecelina effectsofchronicstaphylococcusaureusinfectiononimmunologicalparametersandfunctionalityofmacrophagesisolatedfrombovinemammarysecretions AT englercarolina effectsofchronicstaphylococcusaureusinfectiononimmunologicalparametersandfunctionalityofmacrophagesisolatedfrombovinemammarysecretions AT pereyraelizabetamandalorena effectsofchronicstaphylococcusaureusinfectiononimmunologicalparametersandfunctionalityofmacrophagesisolatedfrombovinemammarysecretions AT calvinholuisfernando effectsofchronicstaphylococcusaureusinfectiononimmunologicalparametersandfunctionalityofmacrophagesisolatedfrombovinemammarysecretions AT dallardbibianaelisabet effectsofchronicstaphylococcusaureusinfectiononimmunologicalparametersandfunctionalityofmacrophagesisolatedfrombovinemammarysecretions |