Recent advances in BLV research
Different animal models have been proposed to investigate the mechanisms of Human T-lymphotropic Virus (HTLV)-induced pathogenesis: rats, transgenic and NOD-SCID/γcnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic lim...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
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MDPI
2019
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| Materias: | |
| Acceso en línea: | https://www.mdpi.com/1999-4915/7/11/2929 http://hdl.handle.net/20.500.12123/5307 https://doi.org/10.3390/v7112929 |
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| author | Barez, Pierre-Yves De Brogniez, Alix Carpentier, Alexandre Gazon, Hélène Gillet, Nicolas Gutierrez, Gerónimo Hamaidia, Malik Jacques, Jean-Rock Perike, Srikanth Sriramareddy, Sathya Neelature Renotte, Nathalie Staumont, Bernard Reichert, Michal Trono, Karina Gabriela Willems, Luc |
| author_browse | Barez, Pierre-Yves Carpentier, Alexandre De Brogniez, Alix Gazon, Hélène Gillet, Nicolas Gutierrez, Gerónimo Hamaidia, Malik Jacques, Jean-Rock Perike, Srikanth Reichert, Michal Renotte, Nathalie Sriramareddy, Sathya Neelature Staumont, Bernard Trono, Karina Gabriela Willems, Luc |
| author_facet | Barez, Pierre-Yves De Brogniez, Alix Carpentier, Alexandre Gazon, Hélène Gillet, Nicolas Gutierrez, Gerónimo Hamaidia, Malik Jacques, Jean-Rock Perike, Srikanth Sriramareddy, Sathya Neelature Renotte, Nathalie Staumont, Bernard Reichert, Michal Trono, Karina Gabriela Willems, Luc |
| author_sort | Barez, Pierre-Yves |
| collection | INTA Digital |
| description | Different animal models have been proposed to investigate the mechanisms of Human T-lymphotropic Virus (HTLV)-induced pathogenesis: rats, transgenic and NOD-SCID/γcnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic limitations such as lack of disease relevance, species specificity or inadequate immune response. Another strategy based on a comparative virology approach is to characterize a related pathogen and to speculate on possible shared mechanisms. In this perspective, bovine leukemia virus (BLV), another member of the deltaretrovirus genus, is evolutionary related to HTLV-1. BLV induces lymphoproliferative disorders in ruminants providing useful information on the mechanisms of viral persistence, genetic determinants of pathogenesis and potential novel therapies. |
| format | info:ar-repo/semantics/artículo |
| id | INTA5307 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | MDPI |
| publisherStr | MDPI |
| record_format | dspace |
| spelling | INTA53072019-06-13T12:11:25Z Recent advances in BLV research Barez, Pierre-Yves De Brogniez, Alix Carpentier, Alexandre Gazon, Hélène Gillet, Nicolas Gutierrez, Gerónimo Hamaidia, Malik Jacques, Jean-Rock Perike, Srikanth Sriramareddy, Sathya Neelature Renotte, Nathalie Staumont, Bernard Reichert, Michal Trono, Karina Gabriela Willems, Luc Enfermedades de los Animales Virus Leucemia Bovina Respuesta Inmunológica Ganado Bovino Vacuna Animal Diseases Bovine Leukaemia Virus Immune Response Cattle Vaccines Different animal models have been proposed to investigate the mechanisms of Human T-lymphotropic Virus (HTLV)-induced pathogenesis: rats, transgenic and NOD-SCID/γcnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic limitations such as lack of disease relevance, species specificity or inadequate immune response. Another strategy based on a comparative virology approach is to characterize a related pathogen and to speculate on possible shared mechanisms. In this perspective, bovine leukemia virus (BLV), another member of the deltaretrovirus genus, is evolutionary related to HTLV-1. BLV induces lymphoproliferative disorders in ruminants providing useful information on the mechanisms of viral persistence, genetic determinants of pathogenesis and potential novel therapies. Instituto de Virología Fil: Barez, Pierre-Yves. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica Fil: de Brogniez, Alix. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica Fil: Carpentier, Alexandre. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica Fil: Gazon, Hélène. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica Fil: Gillet, Nicolas. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica Fil: Gutierrez, Gerónimo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Hamaidia, Malik. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica Fil: Jacques, Jean-Rock. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica Fil: Perike, Srikanth. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica Fil: Sriramareddy, Sathya Neelature. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica Fil: Renotte, Nathalie. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica Fil: Staumont, Bernard. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica Fil: Reichert, Michal. National Veterinary Research Institute; Polonia Fil: Trono, Karina Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Willems, Luc. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica 2019-06-13T12:09:52Z 2019-06-13T12:09:52Z 2015-11 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.mdpi.com/1999-4915/7/11/2929 http://hdl.handle.net/20.500.12123/5307 1999-4915 https://doi.org/10.3390/v7112929 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf MDPI Viruses 7 (11) : 6080-6088 (November 2015) |
| spellingShingle | Enfermedades de los Animales Virus Leucemia Bovina Respuesta Inmunológica Ganado Bovino Vacuna Animal Diseases Bovine Leukaemia Virus Immune Response Cattle Vaccines Barez, Pierre-Yves De Brogniez, Alix Carpentier, Alexandre Gazon, Hélène Gillet, Nicolas Gutierrez, Gerónimo Hamaidia, Malik Jacques, Jean-Rock Perike, Srikanth Sriramareddy, Sathya Neelature Renotte, Nathalie Staumont, Bernard Reichert, Michal Trono, Karina Gabriela Willems, Luc Recent advances in BLV research |
| title | Recent advances in BLV research |
| title_full | Recent advances in BLV research |
| title_fullStr | Recent advances in BLV research |
| title_full_unstemmed | Recent advances in BLV research |
| title_short | Recent advances in BLV research |
| title_sort | recent advances in blv research |
| topic | Enfermedades de los Animales Virus Leucemia Bovina Respuesta Inmunológica Ganado Bovino Vacuna Animal Diseases Bovine Leukaemia Virus Immune Response Cattle Vaccines |
| url | https://www.mdpi.com/1999-4915/7/11/2929 http://hdl.handle.net/20.500.12123/5307 https://doi.org/10.3390/v7112929 |
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