Advances in novel vaccines for foot and mouth disease: focus on recombinant empty capsids
Foot and mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals, which causes severe economic losses in the livestock industry. Currently available vaccines are based on inactivated FMD virus (FMDV). Although inactivated virus vaccines have proved to be effective in FMD control,...
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| Format: | Artículo |
| Language: | Inglés |
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Taylor & Francis
2019
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| Online Access: | http://hdl.handle.net/20.500.12123/5149 https://www.tandfonline.com/doi/abs/10.1080/07388551.2018.1554619?journalCode=ibty20 https://doi.org/10.1080/07388551.2018.1554619 |
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| author | Mignaqui, Ana Clara Ruiz, Vanesa Durocher, Yves Wigdorovitz, Andres |
| author_browse | Durocher, Yves Mignaqui, Ana Clara Ruiz, Vanesa Wigdorovitz, Andres |
| author_facet | Mignaqui, Ana Clara Ruiz, Vanesa Durocher, Yves Wigdorovitz, Andres |
| author_sort | Mignaqui, Ana Clara |
| collection | INTA Digital |
| description | Foot and mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals, which causes severe economic losses in the livestock industry. Currently available vaccines are based on inactivated FMD virus (FMDV). Although inactivated virus vaccines have proved to be effective in FMD control, they have a number of disadvantages, including the need for high bio-containment production facilities and the lack of induction of immunological memory. Novel FMD vaccines based on the use of recombinant empty capsids have shown promising results. These recombinant empty capsids are attractive candidates because they avoid the use of virus in the production facilities but conserve its complete repertoire of conformational epitopes. However, many of these recombinant empty capsids require time-consuming procedures that are difficult to scale up. Achieving production of a novel and efficient FMD vaccine requires not only immunogenic antigens, but also industrially relevant processes. This review intends to summarize and compare the different strategies already published for the production of FMDV recombinant empty capsids, focusing on large-scale production. |
| format | Artículo |
| id | INTA5149 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Taylor & Francis |
| publisherStr | Taylor & Francis |
| record_format | dspace |
| spelling | INTA51492024-07-11T10:31:30Z Advances in novel vaccines for foot and mouth disease: focus on recombinant empty capsids Mignaqui, Ana Clara Ruiz, Vanesa Durocher, Yves Wigdorovitz, Andres Aphthovirus Vaccines Viruses Virus Fiebre Aftosa Vacuna Virus Foot and mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals, which causes severe economic losses in the livestock industry. Currently available vaccines are based on inactivated FMD virus (FMDV). Although inactivated virus vaccines have proved to be effective in FMD control, they have a number of disadvantages, including the need for high bio-containment production facilities and the lack of induction of immunological memory. Novel FMD vaccines based on the use of recombinant empty capsids have shown promising results. These recombinant empty capsids are attractive candidates because they avoid the use of virus in the production facilities but conserve its complete repertoire of conformational epitopes. However, many of these recombinant empty capsids require time-consuming procedures that are difficult to scale up. Achieving production of a novel and efficient FMD vaccine requires not only immunogenic antigens, but also industrially relevant processes. This review intends to summarize and compare the different strategies already published for the production of FMDV recombinant empty capsids, focusing on large-scale production. Instituto de Virología Fil: Mignaqui, Ana Clara. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Ruiz, Vanesa. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Durocher, Yves. National Research Council Canada. Human Health Therapeutics Research Center; Canadá Fil: Wigdorovitz, Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2019-05-20T11:02:30Z 2019-05-20T11:02:30Z 2019-05 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/5149 https://www.tandfonline.com/doi/abs/10.1080/07388551.2018.1554619?journalCode=ibty20 1549-7801 https://doi.org/10.1080/07388551.2018.1554619 eng info:eu-repograntAgreement/INTA/PNSA/1115052/AR./Epidemiología y desarrollo de estrategias para la prevención y control de enfermedades que afectan la salud pública, enfermedades exóticas y limitantes del comercio internacional. info:eu-repo/semantics/restrictedAccess application/pdf Taylor & Francis Critical Reviews in Biotechnology 39 (3) : 306-320 (Mayo 2019) |
| spellingShingle | Aphthovirus Vaccines Viruses Virus Fiebre Aftosa Vacuna Virus Mignaqui, Ana Clara Ruiz, Vanesa Durocher, Yves Wigdorovitz, Andres Advances in novel vaccines for foot and mouth disease: focus on recombinant empty capsids |
| title | Advances in novel vaccines for foot and mouth disease: focus on recombinant empty capsids |
| title_full | Advances in novel vaccines for foot and mouth disease: focus on recombinant empty capsids |
| title_fullStr | Advances in novel vaccines for foot and mouth disease: focus on recombinant empty capsids |
| title_full_unstemmed | Advances in novel vaccines for foot and mouth disease: focus on recombinant empty capsids |
| title_short | Advances in novel vaccines for foot and mouth disease: focus on recombinant empty capsids |
| title_sort | advances in novel vaccines for foot and mouth disease focus on recombinant empty capsids |
| topic | Aphthovirus Vaccines Viruses Virus Fiebre Aftosa Vacuna Virus |
| url | http://hdl.handle.net/20.500.12123/5149 https://www.tandfonline.com/doi/abs/10.1080/07388551.2018.1554619?journalCode=ibty20 https://doi.org/10.1080/07388551.2018.1554619 |
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