Cover Image
QR Code

Formation of dendrimer-guest complexes as a strategy to increase the solubility of a phenazine N, N′-dioxide derivative with antitumor activity

Poly(amidoamine) and Poly(propylenimine) dendrimers with different generations and peripheral groups were studied as solubility enhancers and nanocarriers for 7-bromo-2-hydroxy-phenazine N5,N10-dioxide. This compound possesses potential antitumoral and anti-trypanosomal activity, but its low solubil...

Full description

Main Authors: Dib, Nahir, Fernández, Luciana, Santo, Marisa, Otero, Luis, Alustiza, Fabrisio Eduardo, Liaudat, Ana Cecilia, Bosch, Pablo, Lavaggi, María Laura, Cerecetto, Hugo, González, Mercedes Florencia
Format: Artículo
Language:Inglés
Published: Elsevier 2019
Subjects:
Bioquímica
Nitrógeno
Citotoxicidad
Nanotecnología
Biochemistry
Nitrogen
Cytotoxicity
Nanotechnology
Química Orgánica
Online Access:https://www.heliyon.com/article/e01528/
https://www.sciencedirect.com/science/article/pii/S2405844018337435
http://hdl.handle.net/20.500.12123/5019
https://doi.org/10.1016/j.heliyon.2019.e01528
Summary:Poly(amidoamine) and Poly(propylenimine) dendrimers with different generations and peripheral groups were studied as solubility enhancers and nanocarriers for 7-bromo-2-hydroxy-phenazine N5,N10-dioxide. This compound possesses potential antitumoral and anti-trypanosomal activity, but its low solubility in physiological media precludes its possible application as therapeutic drug. The amino terminated dendrimers association with the active compounds as observed trough NMR studies showed that electrostatic interactions are essential in the solubilization enhancement process. The obtaining of a stable and no cytotoxic formulation makes the drug-carried association a suitable strategy for the generation of a drug delivery system for phenazine derivatives.

Similar Items