Formation of dendrimer-guest complexes as a strategy to increase the solubility of a phenazine N, N′-dioxide derivative with antitumor activity

Poly(amidoamine) and Poly(propylenimine) dendrimers with different generations and peripheral groups were studied as solubility enhancers and nanocarriers for 7-bromo-2-hydroxy-phenazine N5,N10-dioxide. This compound possesses potential antitumoral and anti-trypanosomal activity, but its low solubil...

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Bibliographic Details

Main Authors:	Dib, Nahir, Fernández, Luciana, Santo, Marisa, Otero, Luis, Alustiza, Fabrisio Eduardo, Liaudat, Ana Cecilia, Bosch, Pablo, Lavaggi, María Laura, Cerecetto, Hugo, González, Mercedes Florencia
Format:	Artículo
Language:	Inglés
Published:	Elsevier 2019
Subjects:	Bioquímica Nitrógeno Citotoxicidad Nanotecnología Biochemistry Nitrogen Cytotoxicity Nanotechnology Química Orgánica
Online Access:	https://www.heliyon.com/article/e01528/ https://www.sciencedirect.com/science/article/pii/S2405844018337435 http://hdl.handle.net/20.500.12123/5019 https://doi.org/10.1016/j.heliyon.2019.e01528