Clostridium perfringens type E virulence traits involved in gut colonization
Clostridium perfringens type E disease in ruminants has been characterized by hemorrhagic enteritis or sudden death. Although type E isolates are defined by the production of alpha and iota toxin, little is known about the pathogenesis of C. perfringens type E infections. Thus far, the role of iota...
| Main Authors: | , , , , |
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| Format: | Artículo |
| Language: | Inglés |
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PLOS
2019
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| Online Access: | http://hdl.handle.net/20.500.12123/4804 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121305 https://doi.org/10.1371/journal.pone.0121305 |
| _version_ | 1855483500072796160 |
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| author | Redondo, Leandro Martín Diaz Carrasco, Juan María Redondo, Enzo Alejandro Delgado, Fernando Oscar Fernandez Miyakawa, Mariano Enrique |
| author_browse | Delgado, Fernando Oscar Diaz Carrasco, Juan María Fernandez Miyakawa, Mariano Enrique Redondo, Enzo Alejandro Redondo, Leandro Martín |
| author_facet | Redondo, Leandro Martín Diaz Carrasco, Juan María Redondo, Enzo Alejandro Delgado, Fernando Oscar Fernandez Miyakawa, Mariano Enrique |
| author_sort | Redondo, Leandro Martín |
| collection | INTA Digital |
| description | Clostridium perfringens type E disease in ruminants has been characterized by hemorrhagic enteritis or sudden death. Although type E isolates are defined by the production of alpha and iota toxin, little is known about the pathogenesis of C. perfringens type E infections. Thus far, the role of iota toxin as a virulence factor is unknown. In this report, iota toxin showed positive effects on adherence and colonization of C. perfringens type E while having negative effect on the adherence of type A cells. In-vitro and in-vivo models suggest that toxinotype E would be particularly adapted to exploit the changes induced by iota toxin in the surface of epithelial cells. In addition, type E strains produce metabolites that affected the growth of potential intra-specific competitors. These results suggest that the alteration of the enterocyte morphology induced by iota toxin concomitantly with the specific increase of type E cell adhesion and the strong intra-specific growth inhibition of other strains could be competitive traits inherent to type E isolates that improve its fitness within the bovine gut environment. |
| format | Artículo |
| id | INTA4804 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | PLOS |
| publisherStr | PLOS |
| record_format | dspace |
| spelling | INTA48042019-04-03T12:00:55Z Clostridium perfringens type E virulence traits involved in gut colonization Redondo, Leandro Martín Diaz Carrasco, Juan María Redondo, Enzo Alejandro Delgado, Fernando Oscar Fernandez Miyakawa, Mariano Enrique Clostridium Perfringens Virulencia Enfermedades Gastrointestinales Bacteriocinas Enteritis Virulence Gastrointestinal Diseases Bacteriocins Gut Colonization Colonización Intestinal Clostridium perfringens type E disease in ruminants has been characterized by hemorrhagic enteritis or sudden death. Although type E isolates are defined by the production of alpha and iota toxin, little is known about the pathogenesis of C. perfringens type E infections. Thus far, the role of iota toxin as a virulence factor is unknown. In this report, iota toxin showed positive effects on adherence and colonization of C. perfringens type E while having negative effect on the adherence of type A cells. In-vitro and in-vivo models suggest that toxinotype E would be particularly adapted to exploit the changes induced by iota toxin in the surface of epithelial cells. In addition, type E strains produce metabolites that affected the growth of potential intra-specific competitors. These results suggest that the alteration of the enterocyte morphology induced by iota toxin concomitantly with the specific increase of type E cell adhesion and the strong intra-specific growth inhibition of other strains could be competitive traits inherent to type E isolates that improve its fitness within the bovine gut environment. Instituto de Patobiología Fil: Redondo, Leandro Martín. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Diaz Carrasco, Juan María. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Redondo, Enzo Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Delgado, Fernando Oscar. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina Fil: Fernandez Miyakawa, Mariano Enrique. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2019-04-03T11:56:38Z 2019-04-03T11:56:38Z 2015-03-23 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/4804 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121305 1932-6203 https://doi.org/10.1371/journal.pone.0121305 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf PLOS PLoS ONE 10 (3) : e0121305. (March 23, 2015) |
| spellingShingle | Clostridium Perfringens Virulencia Enfermedades Gastrointestinales Bacteriocinas Enteritis Virulence Gastrointestinal Diseases Bacteriocins Gut Colonization Colonización Intestinal Redondo, Leandro Martín Diaz Carrasco, Juan María Redondo, Enzo Alejandro Delgado, Fernando Oscar Fernandez Miyakawa, Mariano Enrique Clostridium perfringens type E virulence traits involved in gut colonization |
| title | Clostridium perfringens type E virulence traits involved in gut colonization |
| title_full | Clostridium perfringens type E virulence traits involved in gut colonization |
| title_fullStr | Clostridium perfringens type E virulence traits involved in gut colonization |
| title_full_unstemmed | Clostridium perfringens type E virulence traits involved in gut colonization |
| title_short | Clostridium perfringens type E virulence traits involved in gut colonization |
| title_sort | clostridium perfringens type e virulence traits involved in gut colonization |
| topic | Clostridium Perfringens Virulencia Enfermedades Gastrointestinales Bacteriocinas Enteritis Virulence Gastrointestinal Diseases Bacteriocins Gut Colonization Colonización Intestinal |
| url | http://hdl.handle.net/20.500.12123/4804 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121305 https://doi.org/10.1371/journal.pone.0121305 |
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