Distribution of bovine herpesvirus type 1 in the nervous system of experimentally infected calves
Bovine herpesvirus type 1 (BoHV-1) is responsible for respiratory and genital disease in cattle. BoHV-1 encephalitis is only occasionally reported. However, several cases of neurological disease have been recently attributed to BoHV-1. In this study, the distribution and pathological alterations cau...
| Autores principales: | , , , , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
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Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.sciencedirect.com/science/article/pii/S1090023315004438 http://hdl.handle.net/20.500.12123/4791 https://doi.org/10.1016/j.tvjl.2015.10.034 |
| _version_ | 1855035384905334784 |
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| author | Marin, Maia Solange Leunda, Maria Rosa Verna, Andrea Elizabeth Morán, Pedro Edgardo Odeon, Anselmo Carlos Pérez, Sandra Elizabeth |
| author_browse | Leunda, Maria Rosa Marin, Maia Solange Morán, Pedro Edgardo Odeon, Anselmo Carlos Pérez, Sandra Elizabeth Verna, Andrea Elizabeth |
| author_facet | Marin, Maia Solange Leunda, Maria Rosa Verna, Andrea Elizabeth Morán, Pedro Edgardo Odeon, Anselmo Carlos Pérez, Sandra Elizabeth |
| author_sort | Marin, Maia Solange |
| collection | INTA Digital |
| description | Bovine herpesvirus type 1 (BoHV-1) is responsible for respiratory and genital disease in cattle. BoHV-1 encephalitis is only occasionally reported. However, several cases of neurological disease have been recently attributed to BoHV-1. In this study, the distribution and pathological alterations caused by two BoHV-1 strains in the nervous system of experimentally infected calves during acute infection and reactivation are described. Calves were inoculated intranasally with BoHV-1 Los Angeles (BoHV-1.LA) or Cooper (BoHV-1.Cooper) strains. Acutely infected calves were euthanased at 6 days (BoHV-1.Cooper, n = 2) and 7 days post-inoculation (BoHV-1.LA, n = 2). Latently infected calves that were given dexamethasone to induce reactivation were euthanased at 2 days (BoHV-1.Cooper, n = 2) or 5 days (BoHV-1.LA, n = 2) after dexamethasone administration.
Both BoHV-1 strains were isolated from the brains of acutely infected calves. Distribution of viral DNA in the neural tissues was similar for both strains. During reactivation, neither BoHV-1.LA nor BoHV-1.Cooper was isolated from any brain section or trigeminal ganglia in infected calves. Macroscopic lesions were not evident in any group. In BoHV-1.LA infected calves, microscopic lesions were found in the brain but not in the trigeminal ganglia. Microscopic lesions in the brain of BoHV-1.Cooper infected calves were not as evident as in BoHV-1.LA infected animals. However, mononuclear infiltrates and neuronophagia were present in trigeminal ganglia. The results of this study demonstrated that respiratory BoHV-1 strains are able to replicate and disseminate within the bovine nervous tissue and provide evidence of the neuroinvasiveness of BoHV-1 strains. |
| format | info:ar-repo/semantics/artículo |
| id | INTA4791 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA47912019-04-01T11:53:06Z Distribution of bovine herpesvirus type 1 in the nervous system of experimentally infected calves Marin, Maia Solange Leunda, Maria Rosa Verna, Andrea Elizabeth Morán, Pedro Edgardo Odeon, Anselmo Carlos Pérez, Sandra Elizabeth Enfermedades de los Animales Herpes Virus Bovino Ternero Sistema Nervioso Animal Diseases Bovine Herpesvirus Calves Nervous System Bovine herpesvirus type 1 (BoHV-1) is responsible for respiratory and genital disease in cattle. BoHV-1 encephalitis is only occasionally reported. However, several cases of neurological disease have been recently attributed to BoHV-1. In this study, the distribution and pathological alterations caused by two BoHV-1 strains in the nervous system of experimentally infected calves during acute infection and reactivation are described. Calves were inoculated intranasally with BoHV-1 Los Angeles (BoHV-1.LA) or Cooper (BoHV-1.Cooper) strains. Acutely infected calves were euthanased at 6 days (BoHV-1.Cooper, n = 2) and 7 days post-inoculation (BoHV-1.LA, n = 2). Latently infected calves that were given dexamethasone to induce reactivation were euthanased at 2 days (BoHV-1.Cooper, n = 2) or 5 days (BoHV-1.LA, n = 2) after dexamethasone administration. Both BoHV-1 strains were isolated from the brains of acutely infected calves. Distribution of viral DNA in the neural tissues was similar for both strains. During reactivation, neither BoHV-1.LA nor BoHV-1.Cooper was isolated from any brain section or trigeminal ganglia in infected calves. Macroscopic lesions were not evident in any group. In BoHV-1.LA infected calves, microscopic lesions were found in the brain but not in the trigeminal ganglia. Microscopic lesions in the brain of BoHV-1.Cooper infected calves were not as evident as in BoHV-1.LA infected animals. However, mononuclear infiltrates and neuronophagia were present in trigeminal ganglia. The results of this study demonstrated that respiratory BoHV-1 strains are able to replicate and disseminate within the bovine nervous tissue and provide evidence of the neuroinvasiveness of BoHV-1 strains. EEA Balcarce Fil: Marin, Maia Solange. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina Fil: Leunda, Maria Rosa. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina Fil: Verna, Andrea Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina Fil: Morán, Pedro Edgardo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina Fil: Odeón, Anselmo Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina Fil: Perez, Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina 2019-04-01T11:51:19Z 2019-04-01T11:51:19Z 2016-03 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.sciencedirect.com/science/article/pii/S1090023315004438 http://hdl.handle.net/20.500.12123/4791 1090-0233 https://doi.org/10.1016/j.tvjl.2015.10.034 eng info:eu-repo/semantics/restrictedAccess application/pdf Elsevier Veterinary Journal 209 : 82-86 (March 2016) |
| spellingShingle | Enfermedades de los Animales Herpes Virus Bovino Ternero Sistema Nervioso Animal Diseases Bovine Herpesvirus Calves Nervous System Marin, Maia Solange Leunda, Maria Rosa Verna, Andrea Elizabeth Morán, Pedro Edgardo Odeon, Anselmo Carlos Pérez, Sandra Elizabeth Distribution of bovine herpesvirus type 1 in the nervous system of experimentally infected calves |
| title | Distribution of bovine herpesvirus type 1 in the nervous system of experimentally infected calves |
| title_full | Distribution of bovine herpesvirus type 1 in the nervous system of experimentally infected calves |
| title_fullStr | Distribution of bovine herpesvirus type 1 in the nervous system of experimentally infected calves |
| title_full_unstemmed | Distribution of bovine herpesvirus type 1 in the nervous system of experimentally infected calves |
| title_short | Distribution of bovine herpesvirus type 1 in the nervous system of experimentally infected calves |
| title_sort | distribution of bovine herpesvirus type 1 in the nervous system of experimentally infected calves |
| topic | Enfermedades de los Animales Herpes Virus Bovino Ternero Sistema Nervioso Animal Diseases Bovine Herpesvirus Calves Nervous System |
| url | https://www.sciencedirect.com/science/article/pii/S1090023315004438 http://hdl.handle.net/20.500.12123/4791 https://doi.org/10.1016/j.tvjl.2015.10.034 |
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