Closantel plasma and milk disposition in dairy goats: assessment of drug residues in cheese and ricotta
Closantel (CLS) is currently used in programs for the strategic control of gastrointestinal nematodes. CLS is extralabel used in different dairy goat production systems. From available data in dairy cows, it can be concluded that residues of CLS persist in milk. The current work evaluated the concen...
| Autores principales: | , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
Wiley
2019
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| Materias: | |
| Acceso en línea: | https://onlinelibrary.wiley.com/doi/abs/10.1111/jvp.12135 http://hdl.handle.net/20.500.12123/4727 https://doi.org/10.1111/jvp.12135 |
| _version_ | 1855483486221107200 |
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| author | Iezzi, Sebastián Juan Lifschitz, Adrian Luis Sallovitz, Juan Manuel Nejamkin, Pablo Lloberas, María Mercedes Manazza, Jorge Alberto Lanusse, Carlos Edmundo Imperiale, Fernanda Andrea |
| author_browse | Iezzi, Sebastián Juan Imperiale, Fernanda Andrea Lanusse, Carlos Edmundo Lifschitz, Adrian Luis Lloberas, María Mercedes Manazza, Jorge Alberto Nejamkin, Pablo Sallovitz, Juan Manuel |
| author_facet | Iezzi, Sebastián Juan Lifschitz, Adrian Luis Sallovitz, Juan Manuel Nejamkin, Pablo Lloberas, María Mercedes Manazza, Jorge Alberto Lanusse, Carlos Edmundo Imperiale, Fernanda Andrea |
| author_sort | Iezzi, Sebastián Juan |
| collection | INTA Digital |
| description | Closantel (CLS) is currently used in programs for the strategic control of gastrointestinal nematodes. CLS is extralabel used in different dairy goat production systems. From available data in dairy cows, it can be concluded that residues of CLS persist in milk. The current work evaluated the concentration profiles of CLS in plasma and milk from lactating orally treated dairy goats to assess the residues pattern in dairy products such as cheese and ricotta. Six (6) female Saanen dairy goats were treated orally with CLS administered at 10 mg/kg. Blood and milk samples were collected between 0 and 36 days post‐treatment. The whole milk production was collected at 1, 4, 7, and 10 days post‐treatment to produce soft cheese and ricotta. CLS concentrations in plasma, milk, cheese, whey, and ricotta were determined by HPLC. The concentrations of CLS measured in plasma were higher than those measured in milk at all sampling times. However, the calculated withdrawal time for CLS in milk was between 39 and 43 days postadministration to dairy goats. CLS residual concentrations in cheese (between 0.93 and 1.8 μg/g) were higher than those measured in the milk used for its production. CLS concentrations in ricotta were sixfold higher than those in the milk and 20‐fold higher than those in the whey used for its production. The persistent and high residual concentrations of CLS in the milk and in the cheese and ricotta should be seriously considered before issuing any recommendation on the extralabel use of CLS in dairy goat farms. |
| format | Artículo |
| id | INTA4727 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | INTA47272019-03-25T15:34:19Z Closantel plasma and milk disposition in dairy goats: assessment of drug residues in cheese and ricotta Iezzi, Sebastián Juan Lifschitz, Adrian Luis Sallovitz, Juan Manuel Nejamkin, Pablo Lloberas, María Mercedes Manazza, Jorge Alberto Lanusse, Carlos Edmundo Imperiale, Fernanda Andrea Caprinos Leche de Cabra Residuos de Medicamentos Queso Queso Ricotta Goats Goat Milk Drug Residues Cheese Ricotta Cheese Closantel Closantel (CLS) is currently used in programs for the strategic control of gastrointestinal nematodes. CLS is extralabel used in different dairy goat production systems. From available data in dairy cows, it can be concluded that residues of CLS persist in milk. The current work evaluated the concentration profiles of CLS in plasma and milk from lactating orally treated dairy goats to assess the residues pattern in dairy products such as cheese and ricotta. Six (6) female Saanen dairy goats were treated orally with CLS administered at 10 mg/kg. Blood and milk samples were collected between 0 and 36 days post‐treatment. The whole milk production was collected at 1, 4, 7, and 10 days post‐treatment to produce soft cheese and ricotta. CLS concentrations in plasma, milk, cheese, whey, and ricotta were determined by HPLC. The concentrations of CLS measured in plasma were higher than those measured in milk at all sampling times. However, the calculated withdrawal time for CLS in milk was between 39 and 43 days postadministration to dairy goats. CLS residual concentrations in cheese (between 0.93 and 1.8 μg/g) were higher than those measured in the milk used for its production. CLS concentrations in ricotta were sixfold higher than those in the milk and 20‐fold higher than those in the whey used for its production. The persistent and high residual concentrations of CLS in the milk and in the cheese and ricotta should be seriously considered before issuing any recommendation on the extralabel use of CLS in dairy goat farms. EEA Balcarce Fil: Iezzi, Sebastián Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Sallovitz, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Nejamkin, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Lloberas, María Mercedes. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina Fil: Manazza, Jorge Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Imperiale, Fernanda Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina 2019-03-25T15:32:52Z 2019-03-25T15:32:52Z 2014-12 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://onlinelibrary.wiley.com/doi/abs/10.1111/jvp.12135 http://hdl.handle.net/20.500.12123/4727 0140-7783 1365-2885 https://doi.org/10.1111/jvp.12135 eng info:eu-repo/semantics/restrictedAccess application/pdf Wiley Journal of Veterinary Pharmacology and Therapeutics 37 (6) : 589-594 (December 2014) |
| spellingShingle | Caprinos Leche de Cabra Residuos de Medicamentos Queso Queso Ricotta Goats Goat Milk Drug Residues Cheese Ricotta Cheese Closantel Iezzi, Sebastián Juan Lifschitz, Adrian Luis Sallovitz, Juan Manuel Nejamkin, Pablo Lloberas, María Mercedes Manazza, Jorge Alberto Lanusse, Carlos Edmundo Imperiale, Fernanda Andrea Closantel plasma and milk disposition in dairy goats: assessment of drug residues in cheese and ricotta |
| title | Closantel plasma and milk disposition in dairy goats: assessment of drug residues in cheese and ricotta |
| title_full | Closantel plasma and milk disposition in dairy goats: assessment of drug residues in cheese and ricotta |
| title_fullStr | Closantel plasma and milk disposition in dairy goats: assessment of drug residues in cheese and ricotta |
| title_full_unstemmed | Closantel plasma and milk disposition in dairy goats: assessment of drug residues in cheese and ricotta |
| title_short | Closantel plasma and milk disposition in dairy goats: assessment of drug residues in cheese and ricotta |
| title_sort | closantel plasma and milk disposition in dairy goats assessment of drug residues in cheese and ricotta |
| topic | Caprinos Leche de Cabra Residuos de Medicamentos Queso Queso Ricotta Goats Goat Milk Drug Residues Cheese Ricotta Cheese Closantel |
| url | https://onlinelibrary.wiley.com/doi/abs/10.1111/jvp.12135 http://hdl.handle.net/20.500.12123/4727 https://doi.org/10.1111/jvp.12135 |
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