Distribution of bovine alpha-herpesviruses and expression of toll-like receptors in the respiratory system of experimentally infected calves
This study provides an initial analysis of the toll-like receptors (TLRs) that might be implicated in alpha-herpesvirus infection of the bovine respiratory system. A significant variation in the expression of TLR3 and TLRs 7–9 during bovine herpesvirus type 1 (BoHV-1) and 5 (BoHV-5) acute infections...
| Autores principales: | , , , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.sciencedirect.com/science/article/pii/S003452881630008X http://hdl.handle.net/20.500.12123/4568 https://doi.org/10.1016/j.rvsc.2016.01.011 |
| _version_ | 1855035346678448128 |
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| author | Marin, Maia Solange Quintana, Silvina Leunda, Maria Rosa Odeon, Anselmo Carlos Perez, Sandra |
| author_browse | Leunda, Maria Rosa Marin, Maia Solange Odeon, Anselmo Carlos Perez, Sandra Quintana, Silvina |
| author_facet | Marin, Maia Solange Quintana, Silvina Leunda, Maria Rosa Odeon, Anselmo Carlos Perez, Sandra |
| author_sort | Marin, Maia Solange |
| collection | INTA Digital |
| description | This study provides an initial analysis of the toll-like receptors (TLRs) that might be implicated in alpha-herpesvirus infection of the bovine respiratory system. A significant variation in the expression of TLR3 and TLRs 7–9 during bovine herpesvirus type 1 (BoHV-1) and 5 (BoHV-5) acute infections and particularly an up-regulation during viral reactivation in respiratory tissues has been demonstrated. Furthermore, viral distribution in the respiratory tract of BoHV-1- and BoHV-5-infected calves at different stages of the infectious cycle was analysed. The wide distribution of BoHV DNA in the respiratory tract during acute infection was restricted during latent infection and the subsequent reactivation of BoHV-1 and BoHV-5. Overall, the findings presented here contribute to the knowledge on the replication and dissemination of bovine alpha-herpesviruses. Furthermore, some of the immune factors triggered in the host that determine the different outcomes of infection by two closely related pathogens of cattle have been elucidated. |
| format | info:ar-repo/semantics/artículo |
| id | INTA4568 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA45682019-03-11T13:51:29Z Distribution of bovine alpha-herpesviruses and expression of toll-like receptors in the respiratory system of experimentally infected calves Marin, Maia Solange Quintana, Silvina Leunda, Maria Rosa Odeon, Anselmo Carlos Perez, Sandra Ternero Enfermedades de los Animales Herpes Virus Bovino Sistema Respiratorio Experimentación Calves Animal Diseases Bovine Herpesvirus Respiratory System Experimentation This study provides an initial analysis of the toll-like receptors (TLRs) that might be implicated in alpha-herpesvirus infection of the bovine respiratory system. A significant variation in the expression of TLR3 and TLRs 7–9 during bovine herpesvirus type 1 (BoHV-1) and 5 (BoHV-5) acute infections and particularly an up-regulation during viral reactivation in respiratory tissues has been demonstrated. Furthermore, viral distribution in the respiratory tract of BoHV-1- and BoHV-5-infected calves at different stages of the infectious cycle was analysed. The wide distribution of BoHV DNA in the respiratory tract during acute infection was restricted during latent infection and the subsequent reactivation of BoHV-1 and BoHV-5. Overall, the findings presented here contribute to the knowledge on the replication and dissemination of bovine alpha-herpesviruses. Furthermore, some of the immune factors triggered in the host that determine the different outcomes of infection by two closely related pathogens of cattle have been elucidated. EEA Balcarce Fil: Marin, Maia Solange. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Quintana, Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Análisis Fares Taie; Argentina Fil: Leunda, Maria Rosa. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina Fil: Odeón, Anselmo Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina Fil: Perez, Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina 2019-03-11T13:49:39Z 2019-03-11T13:49:39Z 2016-04 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.sciencedirect.com/science/article/pii/S003452881630008X http://hdl.handle.net/20.500.12123/4568 0034-5288 https://doi.org/10.1016/j.rvsc.2016.01.011 eng info:eu-repo/semantics/restrictedAccess application/pdf Elsevier Research in Veterinary Science 105 : 53-55 (April 2016) |
| spellingShingle | Ternero Enfermedades de los Animales Herpes Virus Bovino Sistema Respiratorio Experimentación Calves Animal Diseases Bovine Herpesvirus Respiratory System Experimentation Marin, Maia Solange Quintana, Silvina Leunda, Maria Rosa Odeon, Anselmo Carlos Perez, Sandra Distribution of bovine alpha-herpesviruses and expression of toll-like receptors in the respiratory system of experimentally infected calves |
| title | Distribution of bovine alpha-herpesviruses and expression of toll-like receptors in the respiratory system of experimentally infected calves |
| title_full | Distribution of bovine alpha-herpesviruses and expression of toll-like receptors in the respiratory system of experimentally infected calves |
| title_fullStr | Distribution of bovine alpha-herpesviruses and expression of toll-like receptors in the respiratory system of experimentally infected calves |
| title_full_unstemmed | Distribution of bovine alpha-herpesviruses and expression of toll-like receptors in the respiratory system of experimentally infected calves |
| title_short | Distribution of bovine alpha-herpesviruses and expression of toll-like receptors in the respiratory system of experimentally infected calves |
| title_sort | distribution of bovine alpha herpesviruses and expression of toll like receptors in the respiratory system of experimentally infected calves |
| topic | Ternero Enfermedades de los Animales Herpes Virus Bovino Sistema Respiratorio Experimentación Calves Animal Diseases Bovine Herpesvirus Respiratory System Experimentation |
| url | https://www.sciencedirect.com/science/article/pii/S003452881630008X http://hdl.handle.net/20.500.12123/4568 https://doi.org/10.1016/j.rvsc.2016.01.011 |
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