Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy
Neospora caninum infection in cattle stimulates host immune responses, which may be responsible for placental damage leading to abortion. Susceptibility of water buffaloes (Bubalus bubalis) to neosporosis is not well understood, although vertical transmission and fetal death have been documented. Th...
| Autores principales: | , , , , , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
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Elsevier
2019
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/4559 https://www.sciencedirect.com/science/article/pii/S0021997513003836 https://doi.org/10.1016/j.jcpa.2013.12.003 |
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| author | Canton, German Jose Konrad, Jose Luis Moore, Prando Dadin Caspe, Sergio Gaston Palarea-Albaladejo, Javier Campero, Carlos Manuel Chianini, Francesca |
| author_browse | Campero, Carlos Manuel Canton, German Jose Caspe, Sergio Gaston Chianini, Francesca Konrad, Jose Luis Moore, Prando Dadin Palarea-Albaladejo, Javier |
| author_facet | Canton, German Jose Konrad, Jose Luis Moore, Prando Dadin Caspe, Sergio Gaston Palarea-Albaladejo, Javier Campero, Carlos Manuel Chianini, Francesca |
| author_sort | Canton, German Jose |
| collection | INTA Digital |
| description | Neospora caninum infection in cattle stimulates host immune responses, which may be responsible for placental damage leading to abortion. Susceptibility of water buffaloes (Bubalus bubalis) to neosporosis is not well understood, although vertical transmission and fetal death have been documented. The aim of this study was to characterize the immune response in the placentome of water buffalo following experimental infection in early gestation with the Nc-1 strain of N. caninum. Placentomes were examined by immunohistochemistry using antibodies specific for T-cell subsets, natural killer cells and CD79αcy cells. Placental inflammation was characterized by the infiltration of CD3+ and CD4+ T cells and T cells expressing the γδ T-cell receptor. The distribution of these cellular subsets in buffalo placentomes was similar to that previously described in cattle infected with N. caninum in early gestation, but the lesions were milder, which may explain the lower number of abortions observed in this species after infection. |
| format | info:ar-repo/semantics/artículo |
| id | INTA4559 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA45592021-09-30T13:42:13Z Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy Canton, German Jose Konrad, Jose Luis Moore, Prando Dadin Caspe, Sergio Gaston Palarea-Albaladejo, Javier Campero, Carlos Manuel Chianini, Francesca Neospora caninum Respuesta Inmunológica Búfalo de Agua Gestación Inmunidad Immune Response Water Buffaloes Pregnancy Immunity Neospora caninum infection in cattle stimulates host immune responses, which may be responsible for placental damage leading to abortion. Susceptibility of water buffaloes (Bubalus bubalis) to neosporosis is not well understood, although vertical transmission and fetal death have been documented. The aim of this study was to characterize the immune response in the placentome of water buffalo following experimental infection in early gestation with the Nc-1 strain of N. caninum. Placentomes were examined by immunohistochemistry using antibodies specific for T-cell subsets, natural killer cells and CD79αcy cells. Placental inflammation was characterized by the infiltration of CD3+ and CD4+ T cells and T cells expressing the γδ T-cell receptor. The distribution of these cellular subsets in buffalo placentomes was similar to that previously described in cattle infected with N. caninum in early gestation, but the lesions were milder, which may explain the lower number of abortions observed in this species after infection. EEA Balcarce Fil: Canton, German Jose. Moredun Research Institute; Reino Unido. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina Fil: Konrad, Jose Luis. Universidad Nacional del Nordeste. Facultad de Veterinaria; Argentina Fil: Moore, Prando Dadin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Caspe, Sergio Gaston. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; Argentina Fil: Palarea-Albaladejo, Javier. Biomathematics & Statistics Scotland; Reino Unido Fil: Campero, Carlos Manuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina Fil: Chianini, Francesca. Moredun Research Institute; Reino Unido 2019-03-08T13:56:25Z 2019-03-08T13:56:25Z 2014-05 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion http://hdl.handle.net/20.500.12123/4559 https://www.sciencedirect.com/science/article/pii/S0021997513003836 0021-9975 https://doi.org/10.1016/j.jcpa.2013.12.003 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Elsevier Journal of Comparative Pathology 150 (4) : 463-468 (May 2014) |
| spellingShingle | Neospora caninum Respuesta Inmunológica Búfalo de Agua Gestación Inmunidad Immune Response Water Buffaloes Pregnancy Immunity Canton, German Jose Konrad, Jose Luis Moore, Prando Dadin Caspe, Sergio Gaston Palarea-Albaladejo, Javier Campero, Carlos Manuel Chianini, Francesca Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy |
| title | Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy |
| title_full | Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy |
| title_fullStr | Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy |
| title_full_unstemmed | Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy |
| title_short | Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy |
| title_sort | characterization of immune cell infiltration in the placentome of water buffaloes bubalus bubalis infected with neospora caninum during pregnancy |
| topic | Neospora caninum Respuesta Inmunológica Búfalo de Agua Gestación Inmunidad Immune Response Water Buffaloes Pregnancy Immunity |
| url | http://hdl.handle.net/20.500.12123/4559 https://www.sciencedirect.com/science/article/pii/S0021997513003836 https://doi.org/10.1016/j.jcpa.2013.12.003 |
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