Tuberculosis vaccine candidates based on mycobacterial cell envelope components
Even after decades searching for a new and more effective vaccine against tuberculosis, the scientific community is still pursuing this goal due to the complexity of its causative agent, Mycobacterium tuberculosis (Mtb). Mtb is a microorganism with a robust variety of survival mechanisms that allow...
| Main Authors: | , , , , , , , , |
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| Format: | info:ar-repo/semantics/artículo |
| Language: | Inglés |
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Elsevier
2019
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.12123/4520 https://www.sciencedirect.com/science/article/pii/S1472979218304943?via%3Dihub https://doi.org/10.1016/j.tube.2019.01.003 |
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| author | Sarmiento, María E. Alvarez, N. Chin, K.L. Bigi, Fabiana Tirado Hernández, Yanely García, M.A. Anis, F.Z. Norazmi, Mohd Nor Acosta, Armando |
| author_browse | Acosta, Armando Alvarez, N. Anis, F.Z. Bigi, Fabiana Chin, K.L. García, M.A. Norazmi, Mohd Nor Sarmiento, María E. Tirado Hernández, Yanely |
| author_facet | Sarmiento, María E. Alvarez, N. Chin, K.L. Bigi, Fabiana Tirado Hernández, Yanely García, M.A. Anis, F.Z. Norazmi, Mohd Nor Acosta, Armando |
| author_sort | Sarmiento, María E. |
| collection | INTA Digital |
| description | Even after decades searching for a new and more effective vaccine against tuberculosis, the scientific community is still pursuing this goal due to the complexity of its causative agent, Mycobacterium tuberculosis (Mtb). Mtb is a microorganism with a robust variety of survival mechanisms that allow it to remain in the host for years. The structure and nature of the Mtb envelope play a leading role in its resistance and survival. Mtb has a perfect machinery that allows it to modulate the immune response in its favor and to adapt to the host's environmental conditions in order to remain alive until the moment to reactivate its normal growing state. Mtb cell envelope protein, carbohydrate and lipid components have been the subject of interest for developing new vaccines because most of them are responsible for the pathogenicity and virulence of the bacteria. Many indirect evidences, mainly derived from the use of monoclonal antibodies, support the potential protective role of Mtb envelope components. Subunit and DNA vaccines, lipid extracts, liposomes and membrane vesicle formulations are some examples of technologies used, with encouraging results, to evaluate the potential of these antigens in the protective response against Mtb. |
| format | info:ar-repo/semantics/artículo |
| id | INTA4520 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA45202019-02-28T16:51:32Z Tuberculosis vaccine candidates based on mycobacterial cell envelope components Sarmiento, María E. Alvarez, N. Chin, K.L. Bigi, Fabiana Tirado Hernández, Yanely García, M.A. Anis, F.Z. Norazmi, Mohd Nor Acosta, Armando Mycobacterium tuberculosis Vacuna Pared Celular Membrana Tuberculosis Vaccines Cell Walls Membranes Even after decades searching for a new and more effective vaccine against tuberculosis, the scientific community is still pursuing this goal due to the complexity of its causative agent, Mycobacterium tuberculosis (Mtb). Mtb is a microorganism with a robust variety of survival mechanisms that allow it to remain in the host for years. The structure and nature of the Mtb envelope play a leading role in its resistance and survival. Mtb has a perfect machinery that allows it to modulate the immune response in its favor and to adapt to the host's environmental conditions in order to remain alive until the moment to reactivate its normal growing state. Mtb cell envelope protein, carbohydrate and lipid components have been the subject of interest for developing new vaccines because most of them are responsible for the pathogenicity and virulence of the bacteria. Many indirect evidences, mainly derived from the use of monoclonal antibodies, support the potential protective role of Mtb envelope components. Subunit and DNA vaccines, lipid extracts, liposomes and membrane vesicle formulations are some examples of technologies used, with encouraging results, to evaluate the potential of these antigens in the protective response against Mtb. Instituto de Biotecnología Fil: Sarmiento, María E. Universiti Sains Malaysia. School of Health Sciences; Malasia Fil: Alvarez, N. Public Health Research Institute. Rutgers New Jersey Medical School; Estados Unidos Fil: Chin, K.L. Universiti Malaysia Sabah. Faculty of Medicine and Health Sciences. Department of Biomedical Sciences and Therapeutic; Malasia Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina Fil: Tirado Hernández, Yanely. Instituto Finlay de Vacunas; Cuba Fil: García, M.A. Instituto Finlay de Vacunas; Cuba Fil: Anis, F.Z. Universiti Sains Malaysia. School of Health Sciences; Malasia Fil: Norazmi, Mohd Nor. Universiti Sains Malaysia. School of Health Sciences; Malasia Fil: Acosta, Armando. Universiti Sains Malaysia. School of Health Sciences; Malasia 2019-02-28T16:47:34Z 2019-02-28T16:47:34Z 2019-03 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/4520 https://www.sciencedirect.com/science/article/pii/S1472979218304943?via%3Dihub 1472-9792 https://doi.org/10.1016/j.tube.2019.01.003 eng info:eu-repo/semantics/restrictedAccess application/pdf Elsevier Tuberculosis 115 : 26-41. (March 2019) |
| spellingShingle | Mycobacterium tuberculosis Vacuna Pared Celular Membrana Tuberculosis Vaccines Cell Walls Membranes Sarmiento, María E. Alvarez, N. Chin, K.L. Bigi, Fabiana Tirado Hernández, Yanely García, M.A. Anis, F.Z. Norazmi, Mohd Nor Acosta, Armando Tuberculosis vaccine candidates based on mycobacterial cell envelope components |
| title | Tuberculosis vaccine candidates based on mycobacterial cell envelope components |
| title_full | Tuberculosis vaccine candidates based on mycobacterial cell envelope components |
| title_fullStr | Tuberculosis vaccine candidates based on mycobacterial cell envelope components |
| title_full_unstemmed | Tuberculosis vaccine candidates based on mycobacterial cell envelope components |
| title_short | Tuberculosis vaccine candidates based on mycobacterial cell envelope components |
| title_sort | tuberculosis vaccine candidates based on mycobacterial cell envelope components |
| topic | Mycobacterium tuberculosis Vacuna Pared Celular Membrana Tuberculosis Vaccines Cell Walls Membranes |
| url | http://hdl.handle.net/20.500.12123/4520 https://www.sciencedirect.com/science/article/pii/S1472979218304943?via%3Dihub https://doi.org/10.1016/j.tube.2019.01.003 |
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