Catechin and quercetin attenuate adipose inflammation in fructose‐fed rats and 3T3‐L1 adipocytes
Scope This study evaluated the capacity of dietary catechin (C), quercetin (Q), and the combination of both (CQ), to attenuate adipose inflammation triggered by high fructose (HFr) consumption in rats and by tumor necrosis factor alpha (TNF‐α) in 3T3‐L1 adipocytes. Methods and results In rats, HF...
| Autores principales: | , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
Wiley
2019
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/4509 https://doi.org/10.1002/mnfr.201400631 |
| _version_ | 1855483446976053248 |
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| author | Vazquez Prieto, Marcela Alejandra Bettaieb, Ahmed Rodriguez Lanzi, Cecilia Soto Vargas, Verónica Carolina Perdicaro, Diahann Jeanette Galmarini, Claudio Romulo Haj, Fawaz G. Miatello, Roberto Miguel Oteiza, Patricia I. |
| author_browse | Bettaieb, Ahmed Galmarini, Claudio Romulo Haj, Fawaz G. Miatello, Roberto Miguel Oteiza, Patricia I. Perdicaro, Diahann Jeanette Rodriguez Lanzi, Cecilia Soto Vargas, Verónica Carolina Vazquez Prieto, Marcela Alejandra |
| author_facet | Vazquez Prieto, Marcela Alejandra Bettaieb, Ahmed Rodriguez Lanzi, Cecilia Soto Vargas, Verónica Carolina Perdicaro, Diahann Jeanette Galmarini, Claudio Romulo Haj, Fawaz G. Miatello, Roberto Miguel Oteiza, Patricia I. |
| author_sort | Vazquez Prieto, Marcela Alejandra |
| collection | INTA Digital |
| description | Scope
This study evaluated the capacity of dietary catechin (C), quercetin (Q), and the combination of both (CQ), to attenuate adipose inflammation triggered by high fructose (HFr) consumption in rats and by tumor necrosis factor alpha (TNF‐α) in 3T3‐L1 adipocytes.
Methods and results
In rats, HFr consumption for 6 wk caused dyslipidemia, insulin resistance, reduced plasma adiponectin, adiposity, and adipose tissue inflammation. Dietary supplementation with 20 mg/kg/day of C, Q, and CQ improved all these parameters. In 3T3‐L1 adipocytes, C and Q attenuated TNF‐α‐induced elevated protein carbonyls, increased proinflammatory cytokine expression (MCP‐1, resistin), and decreased adiponectin. The protective effects of C and Q on adipose inflammation are in part associated with their capacity to (i) decrease the activation of the mitogen‐activated kinases (MAPKs) JNK and p38; and (ii) prevent the downregulation of PPAR‐γ. In summary, C and Q, and to a larger extent the combination of both, attenuated adipose proinflammatory signaling cascades and regulated the balance of molecules that improve (adiponectin) or impair (TNF‐α, MCP‐1, resistin) insulin sensitivity.
Conclusion
Together, these findings suggest that dietary Q and C may have potential benefits in mitigating MetS‐associated adipose inflammation, oxidative stress, and insulin resistance. |
| format | Artículo |
| id | INTA4509 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | INTA45092019-02-27T17:25:15Z Catechin and quercetin attenuate adipose inflammation in fructose‐fed rats and 3T3‐L1 adipocytes Vazquez Prieto, Marcela Alejandra Bettaieb, Ahmed Rodriguez Lanzi, Cecilia Soto Vargas, Verónica Carolina Perdicaro, Diahann Jeanette Galmarini, Claudio Romulo Haj, Fawaz G. Miatello, Roberto Miguel Oteiza, Patricia I. Catechin Quercetin Adipose Tissue Inflammation Flavonoids Fructose Catequina Quercetina Tejido Adiposo Inflamación Flavonoides Fructosa Metabolic Syndrome Síndrome Metabólico Scope This study evaluated the capacity of dietary catechin (C), quercetin (Q), and the combination of both (CQ), to attenuate adipose inflammation triggered by high fructose (HFr) consumption in rats and by tumor necrosis factor alpha (TNF‐α) in 3T3‐L1 adipocytes. Methods and results In rats, HFr consumption for 6 wk caused dyslipidemia, insulin resistance, reduced plasma adiponectin, adiposity, and adipose tissue inflammation. Dietary supplementation with 20 mg/kg/day of C, Q, and CQ improved all these parameters. In 3T3‐L1 adipocytes, C and Q attenuated TNF‐α‐induced elevated protein carbonyls, increased proinflammatory cytokine expression (MCP‐1, resistin), and decreased adiponectin. The protective effects of C and Q on adipose inflammation are in part associated with their capacity to (i) decrease the activation of the mitogen‐activated kinases (MAPKs) JNK and p38; and (ii) prevent the downregulation of PPAR‐γ. In summary, C and Q, and to a larger extent the combination of both, attenuated adipose proinflammatory signaling cascades and regulated the balance of molecules that improve (adiponectin) or impair (TNF‐α, MCP‐1, resistin) insulin sensitivity. Conclusion Together, these findings suggest that dietary Q and C may have potential benefits in mitigating MetS‐associated adipose inflammation, oxidative stress, and insulin resistance. EEA La Consulta Fil: Vazquez Prieto, Marcela Alejandra. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Area de Fisiología Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico- Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina Fil: Bettaieb, Ahmed. University of California. Department of Nutrition; Estados Unidos Fil: Rodriguez Lanzi, Cecilia. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Area de Fisiología Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico- Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina Fil: Soto Vargas, Verónica Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; Argentina Fil: Perdicaro, Diahann Jeanette. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Area de Fisiología Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico- Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina Fil: Galmarini, Claudio Romulo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria La Consulta; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias; Argentina Fil: Haj, Fawaz G. University of California. Department of Nutrition; Estados Unidos. University of California. Department of Internal Medicine; Estados Unidos Fil: Miatello, Roberto Miguel. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Area de Fisiología Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico- Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina Fil: Oteiza, Patricia I. University of California. Department of Nutrition; Estados Unidos. University of California. Department of Environmental Toxicology; Estados Unidos 2019-02-27T17:20:41Z 2019-02-27T17:20:41Z 2015-04 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/4509 1613-4125 1613-4133 (Online) https://doi.org/10.1002/mnfr.201400631 eng info:eu-repo/semantics/restrictedAccess application/pdf Wiley Molecular nutrition and food research 59 (4) : 622-633. (April 2015) |
| spellingShingle | Catechin Quercetin Adipose Tissue Inflammation Flavonoids Fructose Catequina Quercetina Tejido Adiposo Inflamación Flavonoides Fructosa Metabolic Syndrome Síndrome Metabólico Vazquez Prieto, Marcela Alejandra Bettaieb, Ahmed Rodriguez Lanzi, Cecilia Soto Vargas, Verónica Carolina Perdicaro, Diahann Jeanette Galmarini, Claudio Romulo Haj, Fawaz G. Miatello, Roberto Miguel Oteiza, Patricia I. Catechin and quercetin attenuate adipose inflammation in fructose‐fed rats and 3T3‐L1 adipocytes |
| title | Catechin and quercetin attenuate adipose inflammation in fructose‐fed rats and 3T3‐L1 adipocytes |
| title_full | Catechin and quercetin attenuate adipose inflammation in fructose‐fed rats and 3T3‐L1 adipocytes |
| title_fullStr | Catechin and quercetin attenuate adipose inflammation in fructose‐fed rats and 3T3‐L1 adipocytes |
| title_full_unstemmed | Catechin and quercetin attenuate adipose inflammation in fructose‐fed rats and 3T3‐L1 adipocytes |
| title_short | Catechin and quercetin attenuate adipose inflammation in fructose‐fed rats and 3T3‐L1 adipocytes |
| title_sort | catechin and quercetin attenuate adipose inflammation in fructose fed rats and 3t3 l1 adipocytes |
| topic | Catechin Quercetin Adipose Tissue Inflammation Flavonoids Fructose Catequina Quercetina Tejido Adiposo Inflamación Flavonoides Fructosa Metabolic Syndrome Síndrome Metabólico |
| url | http://hdl.handle.net/20.500.12123/4509 https://doi.org/10.1002/mnfr.201400631 |
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