An efficient vaccine against bovine leukemia virus
17th International Conference on Human Retroviruses: HTLV and Related Viruses, Trois Ilets, Martinique,(FWI). 18-21 June 2015
| Autores principales: | , , , , , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/4477 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578685/ |
| _version_ | 1855035330532474880 |
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| author | Gutierrez, Gerónimo Rodríguez, Sabrina M. Vilor, Agustín Gillet, Nicolas A. DeBrogniez, Alix Trono, Karina Gabriela Willems, Luc |
| author_browse | DeBrogniez, Alix Gillet, Nicolas A. Gutierrez, Gerónimo Rodríguez, Sabrina M. Trono, Karina Gabriela Vilor, Agustín Willems, Luc |
| author_facet | Gutierrez, Gerónimo Rodríguez, Sabrina M. Vilor, Agustín Gillet, Nicolas A. DeBrogniez, Alix Trono, Karina Gabriela Willems, Luc |
| author_sort | Gutierrez, Gerónimo |
| collection | INTA Digital |
| description | 17th International Conference on Human Retroviruses: HTLV and Related Viruses, Trois Ilets, Martinique,(FWI). 18-21 June 2015 |
| format | info:ar-repo/semantics/artículo |
| id | INTA4477 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | BioMed Central |
| publisherStr | BioMed Central |
| record_format | dspace |
| spelling | INTA44772019-02-21T14:34:54Z An efficient vaccine against bovine leukemia virus Gutierrez, Gerónimo Rodríguez, Sabrina M. Vilor, Agustín Gillet, Nicolas A. DeBrogniez, Alix Trono, Karina Gabriela Willems, Luc Leucemia Leukaemia Virus Leucemia Bovina Bovine Leukaemia Virus Vacuna Vaccines 17th International Conference on Human Retroviruses: HTLV and Related Viruses, Trois Ilets, Martinique,(FWI). 18-21 June 2015 Previous attempts to produce a vaccine against BLV faced problems of efficacy (i.e. only a fraction of animals were protected), persistence (i.e. rapid decrease of immune protection), cost (e.g. production of purified proteins) or safety (e.g. genetically modified hybrid viruses). We have designed a novel strategy based on the use of a live-attenuated BLV provirus. The rationale behind this strategy relies on the deletion of genes required to induce pathogenesis maintaining integrity of those involved in infectivity. We have identified a BLV deleted provirus that is infectious in cattle but replicates at reduced levels in cows as shown by real-time quantitative PCR. The deletant elicits a strong anti-BLV immune response as indicated by wild-type antibody titers. Vaccinated animals but not uninfected controls resist challenge by a wild type BLV virus. The deletant does not spread to uninfected sentinels maintained during 5 years in the same herd supporting biosafety of the vaccine. Passive immunity, but not viral infection, is transmitted to the newborn calves via the maternal colostrum. Assays regarding production, storage and delivery of the vaccine, as well as safety of the milk produced by vaccinated cows are currently being carried out with the aim to start a large scale trial that will be held in Argentina in real dairy conditions during this year. Instituto de Virología Fil: Gutierrez, Gerónimo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Rodríguez, Sabrina M. University of Liège. Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics; Belgica Fil: Vilor, Agustín. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Gillet, Nicolas A. University of Liège. Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics; Belgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Belgica Fil: DeBrogniez, Alix. University of Liège. Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics; Belgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Belgica Fil: Trono, Karina Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Willems, Luc. University of Liège. Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics; Belgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Belgica 2019-02-20T18:14:10Z 2019-02-20T18:14:10Z 2015 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/4477 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578685/ 1742-4690 10.1186/1742-4690-12-S1-I1 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf BioMed Central Retrovirology 12 (Suppl 1) : P3. (2015) |
| spellingShingle | Leucemia Leukaemia Virus Leucemia Bovina Bovine Leukaemia Virus Vacuna Vaccines Gutierrez, Gerónimo Rodríguez, Sabrina M. Vilor, Agustín Gillet, Nicolas A. DeBrogniez, Alix Trono, Karina Gabriela Willems, Luc An efficient vaccine against bovine leukemia virus |
| title | An efficient vaccine against bovine leukemia virus |
| title_full | An efficient vaccine against bovine leukemia virus |
| title_fullStr | An efficient vaccine against bovine leukemia virus |
| title_full_unstemmed | An efficient vaccine against bovine leukemia virus |
| title_short | An efficient vaccine against bovine leukemia virus |
| title_sort | efficient vaccine against bovine leukemia virus |
| topic | Leucemia Leukaemia Virus Leucemia Bovina Bovine Leukaemia Virus Vacuna Vaccines |
| url | http://hdl.handle.net/20.500.12123/4477 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578685/ |
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