Evidence of reduced vertical transmission of Neospora caninum associated with higher IgG1 than IgG2 serum levels and presence of IFN-γ in nonaborting chronically infected cattle under natural condition
Neospora caninum infection of cattle can be vertically transmitted, resulting in abortion or birth of infected calves. Vertical transmission occurs both in acutely or chronically infected cattle. There is little information on the immune response needed to prevent endogenous transplacental transmi...
| Autores principales: | , , , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Español |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/4403 https://www.sciencedirect.com/science/article/pii/S0165242718303933?via%3Dihub https://doi.org/10.1016/j.vetimm.2019.01.001 |
| _version_ | 1855035316454293504 |
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| author | Pereyra, Walter Rodrigo Mansilla, Florencia Celeste Petersen, Marcos Iván Suarez, Victor Humberto Capozzo, Alejandra Victoria |
| author_browse | Capozzo, Alejandra Victoria Mansilla, Florencia Celeste Pereyra, Walter Rodrigo Petersen, Marcos Iván Suarez, Victor Humberto |
| author_facet | Pereyra, Walter Rodrigo Mansilla, Florencia Celeste Petersen, Marcos Iván Suarez, Victor Humberto Capozzo, Alejandra Victoria |
| author_sort | Pereyra, Walter Rodrigo |
| collection | INTA Digital |
| description | Neospora caninum infection of cattle can be vertically transmitted, resulting in abortion or birth of infected
calves. Vertical transmission occurs both in acutely or chronically infected cattle. There is little information on
the immune response needed to prevent endogenous transplacental transmission, particularly from chronically
infected cattle to their offspring in a natural environment. In this study, N. caninum seropositive pregnant cattle
from three different farms with high avidity antibodies and low IgM titers were selected and their newborn
colostrum-deprived calves were tested for anti-N. caninum antibodies. Based on these results, dams were grouped
according to their congenital transmission status. The analysis of the immune profile of the chronically-infected
pregnant cattle revealed that higher ratio between IgG1 and IgG2 anti-N. caninum serum titers and higher levels
of systemic IFN-γ were associated with diminished vertical transmission rates, compared to dams with the opposite
profile. Our results evidenced an association between the immune profile and vertical transmission in nonaborting
chronically infected dams, and confirm that vertical transmission, even when not leading to abortion, is
related to a defined immune profile. This is important information to accomplish successful vaccine development
efforts. |
| format | info:ar-repo/semantics/artículo |
| id | INTA4403 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Español |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA44032023-04-12T16:55:39Z Evidence of reduced vertical transmission of Neospora caninum associated with higher IgG1 than IgG2 serum levels and presence of IFN-γ in nonaborting chronically infected cattle under natural condition Pereyra, Walter Rodrigo Mansilla, Florencia Celeste Petersen, Marcos Iván Suarez, Victor Humberto Capozzo, Alejandra Victoria Neospora Caninum Infección Respuesta Inmunológica Bovina Transmisión de Enfermedades Infection Immune Response Bovinae Vertical Transmission Disease Transmission Transplacental Transmission Chronic Infection IgG Subtypes Neospora caninum infection of cattle can be vertically transmitted, resulting in abortion or birth of infected calves. Vertical transmission occurs both in acutely or chronically infected cattle. There is little information on the immune response needed to prevent endogenous transplacental transmission, particularly from chronically infected cattle to their offspring in a natural environment. In this study, N. caninum seropositive pregnant cattle from three different farms with high avidity antibodies and low IgM titers were selected and their newborn colostrum-deprived calves were tested for anti-N. caninum antibodies. Based on these results, dams were grouped according to their congenital transmission status. The analysis of the immune profile of the chronically-infected pregnant cattle revealed that higher ratio between IgG1 and IgG2 anti-N. caninum serum titers and higher levels of systemic IFN-γ were associated with diminished vertical transmission rates, compared to dams with the opposite profile. Our results evidenced an association between the immune profile and vertical transmission in nonaborting chronically infected dams, and confirm that vertical transmission, even when not leading to abortion, is related to a defined immune profile. This is important information to accomplish successful vaccine development efforts. EEA Salta Fil: Pereyra, Walter Rodrigo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal Chaco Semiarido. Grupo de Patología, Epidemiología e Investigación Diagnóstica-Área de Sanidad Animal; Argentinaía General y Especial; Argentina Fil: Mansilla, Florencia Celeste. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Petersen, Marcos Ivan. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina Fil: Suarez, Victor Humberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal Chaco Semiarido. Grupo de Patología, Epidemiología e Investigación Diagnóstica-Área de Sanidad Animal; Argentinaía General y Especial; Argentina Fil: Capozzo, Alejandra Victoria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina 2019-02-07T15:38:44Z 2019-02-07T15:38:44Z 2019-02 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/4403 https://www.sciencedirect.com/science/article/pii/S0165242718303933?via%3Dihub 0165-2427 https://doi.org/10.1016/j.vetimm.2019.01.001 spa info:eu-repo/semantics/restrictedAccess application/pdf Elsevier Veterinary immunology and immunopathology 208 : 53-57. (February 2019) |
| spellingShingle | Neospora Caninum Infección Respuesta Inmunológica Bovina Transmisión de Enfermedades Infection Immune Response Bovinae Vertical Transmission Disease Transmission Transplacental Transmission Chronic Infection IgG Subtypes Pereyra, Walter Rodrigo Mansilla, Florencia Celeste Petersen, Marcos Iván Suarez, Victor Humberto Capozzo, Alejandra Victoria Evidence of reduced vertical transmission of Neospora caninum associated with higher IgG1 than IgG2 serum levels and presence of IFN-γ in nonaborting chronically infected cattle under natural condition |
| title | Evidence of reduced vertical transmission of Neospora caninum associated with higher IgG1 than IgG2 serum levels and presence of IFN-γ in nonaborting chronically infected cattle under natural condition |
| title_full | Evidence of reduced vertical transmission of Neospora caninum associated with higher IgG1 than IgG2 serum levels and presence of IFN-γ in nonaborting chronically infected cattle under natural condition |
| title_fullStr | Evidence of reduced vertical transmission of Neospora caninum associated with higher IgG1 than IgG2 serum levels and presence of IFN-γ in nonaborting chronically infected cattle under natural condition |
| title_full_unstemmed | Evidence of reduced vertical transmission of Neospora caninum associated with higher IgG1 than IgG2 serum levels and presence of IFN-γ in nonaborting chronically infected cattle under natural condition |
| title_short | Evidence of reduced vertical transmission of Neospora caninum associated with higher IgG1 than IgG2 serum levels and presence of IFN-γ in nonaborting chronically infected cattle under natural condition |
| title_sort | evidence of reduced vertical transmission of neospora caninum associated with higher igg1 than igg2 serum levels and presence of ifn γ in nonaborting chronically infected cattle under natural condition |
| topic | Neospora Caninum Infección Respuesta Inmunológica Bovina Transmisión de Enfermedades Infection Immune Response Bovinae Vertical Transmission Disease Transmission Transplacental Transmission Chronic Infection IgG Subtypes |
| url | http://hdl.handle.net/20.500.12123/4403 https://www.sciencedirect.com/science/article/pii/S0165242718303933?via%3Dihub https://doi.org/10.1016/j.vetimm.2019.01.001 |
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