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Immunization of lambs with the S48 strain of Toxoplasma gondii reduces tissue cyst burden following oral challenge with a complete strain of the parasite

This study evaluates the influence of immunizing lambs with the incomplete S48 strain of Toxoplasma gondii, on parasite dissemination following a live oral challenge with a complete strain of T. gondii (M4). Lambs were culled at 14, 28 and 42 days post challenge. Parasite DNA was detected at signifi...

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Autores principales: Katzer, Frank, Canton, German Jose, Burrels, Alison, Palarea-Albaladejo, Javier, Horton, Ben, Bartley, Paul M., Pang, Yvonne, Chianini, Francesca, Innes, Elisabeth A., Benavides-Silván, Julio
Formato: info:ar-repo/semantics/artículo
Lenguaje:Inglés
Publicado: Elsevier 2019
Materias:
Cordero
Inmunización
Toxoplasma gondii
Vacuna
Toxoplasmosis
Zoonosis
Lambs
Immunization
Vaccines
Zoonoses
Acceso en línea:https://www.sciencedirect.com/science/article/pii/S0304401714003884
http://hdl.handle.net/20.500.12123/4372
https://doi.org/10.1016/j.vetpar.2014.07.003
Sumario:This study evaluates the influence of immunizing lambs with the incomplete S48 strain of Toxoplasma gondii, on parasite dissemination following a live oral challenge with a complete strain of T. gondii (M4). Lambs were culled at 14, 28 and 42 days post challenge. Parasite DNA was detected at significantly (p < 0.0001) lower levels in samples from the vaccinated/challenged group (0% in heart and 5.9% in skeletal muscles), when compared to the non-vaccinated/challenged animals (75% heart, 87.9% skeletal muscle). S48 T. gondii DNA was found in muscle or lymph nodes until 42 days post infection, suggesting that parasite DNA or tachyzoites could persist longer after immunization than previously thought. Non-vaccinated/challenged animals showed more frequent lesions in muscles and central nervous system than the vaccinated animals. These results demonstrate that vaccination of lambs with the incomplete S48 T. gondii strain, can protect against establishment of tissue cysts following challenge with a complete strain of T. gondii. Consumption of undercooked meat containing T. gondii cysts is a major route of transmission to people, therefore vaccination of food animals may improve the safety of meat for human consumption.

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