Infectious Bursal Disease Virus non-structural protein VP5 is not a transmembrane protein

Infectious Bursal Disease Virus (IBDV) causes a highly relevant poultry disease that affects young chickens causing, among other effects, immunosuppression. IBDV is a bi-segmented double stranded RNA virus. The smaller ORF of larger RNA segment encodes VP5, a 17-kDa non-structural protein. Although...

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Main Authors: Carballeda, Juan Manuel, Maroniche, Guillermo Andrés, Lucero, Maria Soledad, Richetta, Matias Daniel, Gomez, Evangelina Raquel, Chimeno Zoth, Silvina Andrea, Berinstein, Analia
Format: Artículo
Language:Inglés
Published: Elsevier 2019
Subjects:
Online Access:https://www.sciencedirect.com/science/article/pii/S0042682215002470
http://hdl.handle.net/20.500.12123/4353
https://doi.org/10.1016/j.virol.2015.05.003
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author Carballeda, Juan Manuel
Maroniche, Guillermo Andrés
Lucero, Maria Soledad
Richetta, Matias Daniel
Gomez, Evangelina Raquel
Chimeno Zoth, Silvina Andrea
Berinstein, Analia
author_browse Berinstein, Analia
Carballeda, Juan Manuel
Chimeno Zoth, Silvina Andrea
Gomez, Evangelina Raquel
Lucero, Maria Soledad
Maroniche, Guillermo Andrés
Richetta, Matias Daniel
author_facet Carballeda, Juan Manuel
Maroniche, Guillermo Andrés
Lucero, Maria Soledad
Richetta, Matias Daniel
Gomez, Evangelina Raquel
Chimeno Zoth, Silvina Andrea
Berinstein, Analia
author_sort Carballeda, Juan Manuel
collection INTA Digital
description Infectious Bursal Disease Virus (IBDV) causes a highly relevant poultry disease that affects young chickens causing, among other effects, immunosuppression. IBDV is a bi-segmented double stranded RNA virus. The smaller ORF of larger RNA segment encodes VP5, a 17-kDa non-structural protein. Although it is an important protein for viral replication cycle, the definition of its specific role and subcellular localization remains unclear. In the present work we demonstrate, using imaging techniques, that VP5 is not a type II transmembrane protein but an intracellular membrane-associated protein. This finding might provide evidences of VP5 interaction with cellular proteins and its functions.
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language Inglés
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spelling INTA43532019-01-30T11:37:41Z Infectious Bursal Disease Virus non-structural protein VP5 is not a transmembrane protein Carballeda, Juan Manuel Maroniche, Guillermo Andrés Lucero, Maria Soledad Richetta, Matias Daniel Gomez, Evangelina Raquel Chimeno Zoth, Silvina Andrea Berinstein, Analia Enfermedades de los Animales Virus Bursitis Infecciosa Pollo Proteínas Animal Diseases Infectious Bursal Disease Virus Chickens Proteins Virus Enfermedad de Gumboro Infectious Bursal Disease Virus (IBDV) causes a highly relevant poultry disease that affects young chickens causing, among other effects, immunosuppression. IBDV is a bi-segmented double stranded RNA virus. The smaller ORF of larger RNA segment encodes VP5, a 17-kDa non-structural protein. Although it is an important protein for viral replication cycle, the definition of its specific role and subcellular localization remains unclear. In the present work we demonstrate, using imaging techniques, that VP5 is not a type II transmembrane protein but an intracellular membrane-associated protein. This finding might provide evidences of VP5 interaction with cellular proteins and its functions. Instituto de Biotecnología Fil: Carballeda, Juan Manuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Maroniche, Guillermo Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina Fil: Lucero, Maria Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Richetta, Matias Daniel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina Fil: Gomez, Evangelina Raquel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Chimeno Zoth, Silvina Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Berinstein, Analia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2019-01-30T11:36:38Z 2019-01-30T11:36:38Z 2015-09 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.sciencedirect.com/science/article/pii/S0042682215002470 http://hdl.handle.net/20.500.12123/4353 0042-6822 https://doi.org/10.1016/j.virol.2015.05.003 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Elsevier Virology 483 : 312-317 (September 2015)
spellingShingle Enfermedades de los Animales
Virus Bursitis Infecciosa
Pollo
Proteínas
Animal Diseases
Infectious Bursal Disease Virus
Chickens
Proteins
Virus Enfermedad de Gumboro
Carballeda, Juan Manuel
Maroniche, Guillermo Andrés
Lucero, Maria Soledad
Richetta, Matias Daniel
Gomez, Evangelina Raquel
Chimeno Zoth, Silvina Andrea
Berinstein, Analia
Infectious Bursal Disease Virus non-structural protein VP5 is not a transmembrane protein
title Infectious Bursal Disease Virus non-structural protein VP5 is not a transmembrane protein
title_full Infectious Bursal Disease Virus non-structural protein VP5 is not a transmembrane protein
title_fullStr Infectious Bursal Disease Virus non-structural protein VP5 is not a transmembrane protein
title_full_unstemmed Infectious Bursal Disease Virus non-structural protein VP5 is not a transmembrane protein
title_short Infectious Bursal Disease Virus non-structural protein VP5 is not a transmembrane protein
title_sort infectious bursal disease virus non structural protein vp5 is not a transmembrane protein
topic Enfermedades de los Animales
Virus Bursitis Infecciosa
Pollo
Proteínas
Animal Diseases
Infectious Bursal Disease Virus
Chickens
Proteins
Virus Enfermedad de Gumboro
url https://www.sciencedirect.com/science/article/pii/S0042682215002470
http://hdl.handle.net/20.500.12123/4353
https://doi.org/10.1016/j.virol.2015.05.003
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