Early protection against foot-and-mouth disease virus in cattle using an inactivated vaccine formulated with Montanide ESSAI IMS D 12802 VG PR adjuvant
Foot and mouth disease is an acute disease of cattle with a broad distribution around the world. Due to the fast spread of FMDV infections, control measures must be applied immediately after an outbreak, such as the use of vaccines that induce fast protection. Previously, it was shown that mice vacc...
| Main Authors: | , , , , , |
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| Format: | Artículo |
| Language: | Inglés |
| Published: |
Elsevier
2019
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| Online Access: | https://www.sciencedirect.com/science/article/pii/S0264410X14002461 http://hdl.handle.net/20.500.12123/4343 https://doi.org/10.1016/j.vaccine.2014.02.061 |
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| author | Quattrocchi, Valeria Pappalardo, Juan Sebastián Langellotti, Cecilia Ana Smitsaart, Eliana N. Fondevila, Norberto Antonio Zamorano, Patricia Ines |
| author_browse | Fondevila, Norberto Antonio Langellotti, Cecilia Ana Pappalardo, Juan Sebastián Quattrocchi, Valeria Smitsaart, Eliana N. Zamorano, Patricia Ines |
| author_facet | Quattrocchi, Valeria Pappalardo, Juan Sebastián Langellotti, Cecilia Ana Smitsaart, Eliana N. Fondevila, Norberto Antonio Zamorano, Patricia Ines |
| author_sort | Quattrocchi, Valeria |
| collection | INTA Digital |
| description | Foot and mouth disease is an acute disease of cattle with a broad distribution around the world. Due to the fast spread of FMDV infections, control measures must be applied immediately after an outbreak, such as the use of vaccines that induce fast protection. Previously, it was shown that mice vaccinated with FMD inactivated virus (iFMDV) formulated with Montanide™ ESSAI IMS D 12802 VG PR adjuvant (802-iFMDV) were protected when they were challenged 4 and 7 days post-vaccination (dpv) with homologous virus.
In this work, we describe the successful use of this formulation in cattle. In addition, adjuvant Montanide™ IMS 1313 VG NPR was also tested. 802-iFMDV vaccine was able to confer 100% protection against viral challenge at 4 and 7 dpv, while eliciting low antibody levels, at 7 dpv. 1313-iFMDV vaccine induced protection in 60% of cattle.
At 4 dpv, 1313-iFMDV vaccinated animals presented increased levels of IFNγ but not of macrophages. At 4 and 7 dpv, macrophages, IFNγ, nasal IgA and IgG1 antibodies against FMDV, and opsonophagocytosis were increased in animals vaccinated with 802-iFMDV indicating that these phenomena could be involved in protection.It is the first time that total protection against FMDV at early stages post-vaccination is reported using a single dose of the formulation iFMDV plus Montanide™ ESSAI D IMS 12802 VG PR adjuvant. |
| format | Artículo |
| id | INTA4343 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA43432019-01-28T17:23:34Z Early protection against foot-and-mouth disease virus in cattle using an inactivated vaccine formulated with Montanide ESSAI IMS D 12802 VG PR adjuvant Quattrocchi, Valeria Pappalardo, Juan Sebastián Langellotti, Cecilia Ana Smitsaart, Eliana N. Fondevila, Norberto Antonio Zamorano, Patricia Ines Enfermedades de los Animales Fiebre Aftosa Ganado Bovino Virus Fiebre Aftosa Vacuna Vacuna Inactivada Coadyuvantes Animal Diseases Foot and Mouth Disease Cattle Aphthovirus Vaccines Inactivated Vaccines Adjuvants Foot and mouth disease is an acute disease of cattle with a broad distribution around the world. Due to the fast spread of FMDV infections, control measures must be applied immediately after an outbreak, such as the use of vaccines that induce fast protection. Previously, it was shown that mice vaccinated with FMD inactivated virus (iFMDV) formulated with Montanide™ ESSAI IMS D 12802 VG PR adjuvant (802-iFMDV) were protected when they were challenged 4 and 7 days post-vaccination (dpv) with homologous virus. In this work, we describe the successful use of this formulation in cattle. In addition, adjuvant Montanide™ IMS 1313 VG NPR was also tested. 802-iFMDV vaccine was able to confer 100% protection against viral challenge at 4 and 7 dpv, while eliciting low antibody levels, at 7 dpv. 1313-iFMDV vaccine induced protection in 60% of cattle. At 4 dpv, 1313-iFMDV vaccinated animals presented increased levels of IFNγ but not of macrophages. At 4 and 7 dpv, macrophages, IFNγ, nasal IgA and IgG1 antibodies against FMDV, and opsonophagocytosis were increased in animals vaccinated with 802-iFMDV indicating that these phenomena could be involved in protection.It is the first time that total protection against FMDV at early stages post-vaccination is reported using a single dose of the formulation iFMDV plus Montanide™ ESSAI D IMS 12802 VG PR adjuvant. Instituto de Virología Fil: Quattrocchi, Valeria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Pappalardo, Juan Sebastián. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Langellotti, Cecilia Ana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil:Smitsaart, Eliana N. Biogénesis Bagó S.A.; Argentina Fil: Fondevila, Norberto Antonio. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Zamorano, Patricia Ines. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad del Salvador; Argentina 2019-01-28T17:21:49Z 2019-01-28T17:21:49Z 2014-04-17 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.sciencedirect.com/science/article/pii/S0264410X14002461 http://hdl.handle.net/20.500.12123/4343 0264-410X https://doi.org/10.1016/j.vaccine.2014.02.061 eng info:eu-repo/semantics/restrictedAccess application/pdf Elsevier Vaccine 32 (19) : 2167-2172 (April 2014) |
| spellingShingle | Enfermedades de los Animales Fiebre Aftosa Ganado Bovino Virus Fiebre Aftosa Vacuna Vacuna Inactivada Coadyuvantes Animal Diseases Foot and Mouth Disease Cattle Aphthovirus Vaccines Inactivated Vaccines Adjuvants Quattrocchi, Valeria Pappalardo, Juan Sebastián Langellotti, Cecilia Ana Smitsaart, Eliana N. Fondevila, Norberto Antonio Zamorano, Patricia Ines Early protection against foot-and-mouth disease virus in cattle using an inactivated vaccine formulated with Montanide ESSAI IMS D 12802 VG PR adjuvant |
| title | Early protection against foot-and-mouth disease virus in cattle using an inactivated vaccine formulated with Montanide ESSAI IMS D 12802 VG PR adjuvant |
| title_full | Early protection against foot-and-mouth disease virus in cattle using an inactivated vaccine formulated with Montanide ESSAI IMS D 12802 VG PR adjuvant |
| title_fullStr | Early protection against foot-and-mouth disease virus in cattle using an inactivated vaccine formulated with Montanide ESSAI IMS D 12802 VG PR adjuvant |
| title_full_unstemmed | Early protection against foot-and-mouth disease virus in cattle using an inactivated vaccine formulated with Montanide ESSAI IMS D 12802 VG PR adjuvant |
| title_short | Early protection against foot-and-mouth disease virus in cattle using an inactivated vaccine formulated with Montanide ESSAI IMS D 12802 VG PR adjuvant |
| title_sort | early protection against foot and mouth disease virus in cattle using an inactivated vaccine formulated with montanide essai ims d 12802 vg pr adjuvant |
| topic | Enfermedades de los Animales Fiebre Aftosa Ganado Bovino Virus Fiebre Aftosa Vacuna Vacuna Inactivada Coadyuvantes Animal Diseases Foot and Mouth Disease Cattle Aphthovirus Vaccines Inactivated Vaccines Adjuvants |
| url | https://www.sciencedirect.com/science/article/pii/S0264410X14002461 http://hdl.handle.net/20.500.12123/4343 https://doi.org/10.1016/j.vaccine.2014.02.061 |
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