Novel vaccination approaches against equine alphavirus encephalitides
The current production of inactivated vaccines for the prevention of equine alphavirus encephalitides caused by Eastern, Western and Venezuelan Equine Encephalitis viruses (EEEV, WEEV, VEEV) involves the manipulation of large quantities of infectious viral particles under biosafety level 3 containme...
| Autores principales: | , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
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Elsevier
2019
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| Acceso en línea: | https://www.sciencedirect.com/science/article/pii/S0264410X13016332 http://hdl.handle.net/20.500.12123/4336 https://doi.org/10.1016/j.vaccine.2013.11.071 |
| _version_ | 1855483412691812352 |
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| author | Carossino, Mariano Thiry, Etienne Grandière, Ana de la Barrandeguy, Maria Edith |
| author_browse | Barrandeguy, Maria Edith Carossino, Mariano Grandière, Ana de la Thiry, Etienne |
| author_facet | Carossino, Mariano Thiry, Etienne Grandière, Ana de la Barrandeguy, Maria Edith |
| author_sort | Carossino, Mariano |
| collection | INTA Digital |
| description | The current production of inactivated vaccines for the prevention of equine alphavirus encephalitides caused by Eastern, Western and Venezuelan Equine Encephalitis viruses (EEEV, WEEV, VEEV) involves the manipulation of large quantities of infectious viral particles under biosafety level 3 containment laboratories with the potential risk of transmission to the operators. Moreover, these vaccines are not capable of inducing a long-lasting immunity. Modified live vaccines, which were also attempted, maintain residual virulence and neurotropism, causing disease in both horses and humans. Therefore, the production of an efficacious second generation vaccine which could be used in the prevention of alphavirus infection without the need to manipulate infectious viral particles under high biocontainment conditions could be of great benefit for the worldwide horse industry. Furthermore, equine alphaviruses are considered as biological threat agents. Subunit, chimeric, gene-deleted live mutants, DNA and adenovirus-vectored alphavirus vaccines have been evaluated; such approaches are reviewed in this work.
Climate changes, together with modifications in bird and vector ecology, are leading to the arise of emerging pathogens in new geographical locations, and these zoonotic New World arboviruses are gaining concern. Novel vaccine development does show a promising future for prevention of these infections in both horses and humans. |
| format | Artículo |
| id | INTA4336 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA43362019-01-25T17:14:13Z Novel vaccination approaches against equine alphavirus encephalitides Carossino, Mariano Thiry, Etienne Grandière, Ana de la Barrandeguy, Maria Edith Caballos Enfermedades de los Animales Alphavirus Virus de la Encéfalo Mielitis Equina Vacunación Horses Animal Diseases Equine Encephalomyelitis Virus Vaccination The current production of inactivated vaccines for the prevention of equine alphavirus encephalitides caused by Eastern, Western and Venezuelan Equine Encephalitis viruses (EEEV, WEEV, VEEV) involves the manipulation of large quantities of infectious viral particles under biosafety level 3 containment laboratories with the potential risk of transmission to the operators. Moreover, these vaccines are not capable of inducing a long-lasting immunity. Modified live vaccines, which were also attempted, maintain residual virulence and neurotropism, causing disease in both horses and humans. Therefore, the production of an efficacious second generation vaccine which could be used in the prevention of alphavirus infection without the need to manipulate infectious viral particles under high biocontainment conditions could be of great benefit for the worldwide horse industry. Furthermore, equine alphaviruses are considered as biological threat agents. Subunit, chimeric, gene-deleted live mutants, DNA and adenovirus-vectored alphavirus vaccines have been evaluated; such approaches are reviewed in this work. Climate changes, together with modifications in bird and vector ecology, are leading to the arise of emerging pathogens in new geographical locations, and these zoonotic New World arboviruses are gaining concern. Novel vaccine development does show a promising future for prevention of these infections in both horses and humans. Instituto de Virología Fil: Carossino, Mariano. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virologia; Argentina. Universidad del Salvador. Escuela de Veterinaria; Argentina Fil: Thiry, Etienne. University of Liege. Faculty of Veterinary Medicine. Veterinary Virology and Animal Viral Diseases and UREAR. Department of Infectious and Parasitic Diseases; Bélgica Fil: Grandière, Ana de la. University of Liege. Faculty of Veterinary Medicine. Veterinary Virology and Animal Viral Diseases and UREAR. Department of Infectious and Parasitic Diseases; Bélgica Fil: Barrandeguy, Maria Edith. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Universidad del Salvador. Escuela de Veterinaria; Argentina 2019-01-25T17:12:50Z 2019-01-25T17:12:50Z 2014-01-09 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.sciencedirect.com/science/article/pii/S0264410X13016332 http://hdl.handle.net/20.500.12123/4336 0264-410X https://doi.org/10.1016/j.vaccine.2013.11.071 eng info:eu-repo/semantics/restrictedAccess application/pdf Elsevier Vaccine 32 (3) : 311-319 (January 2014) |
| spellingShingle | Caballos Enfermedades de los Animales Alphavirus Virus de la Encéfalo Mielitis Equina Vacunación Horses Animal Diseases Equine Encephalomyelitis Virus Vaccination Carossino, Mariano Thiry, Etienne Grandière, Ana de la Barrandeguy, Maria Edith Novel vaccination approaches against equine alphavirus encephalitides |
| title | Novel vaccination approaches against equine alphavirus encephalitides |
| title_full | Novel vaccination approaches against equine alphavirus encephalitides |
| title_fullStr | Novel vaccination approaches against equine alphavirus encephalitides |
| title_full_unstemmed | Novel vaccination approaches against equine alphavirus encephalitides |
| title_short | Novel vaccination approaches against equine alphavirus encephalitides |
| title_sort | novel vaccination approaches against equine alphavirus encephalitides |
| topic | Caballos Enfermedades de los Animales Alphavirus Virus de la Encéfalo Mielitis Equina Vacunación Horses Animal Diseases Equine Encephalomyelitis Virus Vaccination |
| url | https://www.sciencedirect.com/science/article/pii/S0264410X13016332 http://hdl.handle.net/20.500.12123/4336 https://doi.org/10.1016/j.vaccine.2013.11.071 |
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