Prediction of aquaporin function by integrating evolutionary and functional analyses
Aquaporins (AQPs) are a family of channel proteins, which transport water and/or small solutes across cell membranes. AQPs are present in Bacteria, Eukarya, and Archaea. The classical AQP evolution paradigm explains the inconsistent phylogenetic trees by multiple transfer events and emphasizes that...
| Autores principales: | , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
Springer
2019
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| Materias: | |
| Acceso en línea: | https://link.springer.com/article/10.1007/s00232-013-9618-8 http://hdl.handle.net/20.500.12123/4332 https://doi.org/10.1007/s00232-013-9618-8 |
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| author | Perez Di Giorgio, Juliana Andrea Soto, Gabriela Cinthia Alleva, Karina Edith Jozefkowicz, Cintia Amodeo, Gabriela Muschietti, Jorge Prometeo Ayub, Nicolás Daniel |
| author_browse | Alleva, Karina Edith Amodeo, Gabriela Ayub, Nicolás Daniel Jozefkowicz, Cintia Muschietti, Jorge Prometeo Perez Di Giorgio, Juliana Andrea Soto, Gabriela Cinthia |
| author_facet | Perez Di Giorgio, Juliana Andrea Soto, Gabriela Cinthia Alleva, Karina Edith Jozefkowicz, Cintia Amodeo, Gabriela Muschietti, Jorge Prometeo Ayub, Nicolás Daniel |
| author_sort | Perez Di Giorgio, Juliana Andrea |
| collection | INTA Digital |
| description | Aquaporins (AQPs) are a family of channel proteins, which transport water and/or small solutes across cell membranes. AQPs are present in Bacteria, Eukarya, and Archaea. The classical AQP evolution paradigm explains the inconsistent phylogenetic trees by multiple transfer events and emphasizes that the assignment of orthologous AQPs is not possible, making it difficult to integrate functional information. Recently, a novel phylogenetic framework of eukaryotic AQP evolution showed congruence between eukaryotic AQPs and organismal trees identifying 32 orthologous clusters in plants and animals (Soto et al. Gene 503:165–176, 2012). In this article, we discuss in depth the methodological strength, the ability to predict functionality and the AQP community perception about the different paradigms of AQP evolution. Moreover, we show an updated review of AQPs transport functions in association with phylogenetic analyses. Finally, we discuss the possible effect of AQP data integration in the understanding of water and solute transport in eukaryotic cells. |
| format | Artículo |
| id | INTA4332 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Springer |
| publisherStr | Springer |
| record_format | dspace |
| spelling | INTA43322019-01-25T12:59:38Z Prediction of aquaporin function by integrating evolutionary and functional analyses Perez Di Giorgio, Juliana Andrea Soto, Gabriela Cinthia Alleva, Karina Edith Jozefkowicz, Cintia Amodeo, Gabriela Muschietti, Jorge Prometeo Ayub, Nicolás Daniel Proteínas Metabolismo Proteíco Experimentación en Laboratorio Células Eucarioticas Proteins Protein Metabolism Laboratory Experimentation Eukaryotic Cells Acuaporinas Aquaporins Aquaporins (AQPs) are a family of channel proteins, which transport water and/or small solutes across cell membranes. AQPs are present in Bacteria, Eukarya, and Archaea. The classical AQP evolution paradigm explains the inconsistent phylogenetic trees by multiple transfer events and emphasizes that the assignment of orthologous AQPs is not possible, making it difficult to integrate functional information. Recently, a novel phylogenetic framework of eukaryotic AQP evolution showed congruence between eukaryotic AQPs and organismal trees identifying 32 orthologous clusters in plants and animals (Soto et al. Gene 503:165–176, 2012). In this article, we discuss in depth the methodological strength, the ability to predict functionality and the AQP community perception about the different paradigms of AQP evolution. Moreover, we show an updated review of AQPs transport functions in association with phylogenetic analyses. Finally, we discuss the possible effect of AQP data integration in the understanding of water and solute transport in eukaryotic cells. Instituto de Genética Fil: Perez Di Giorgio, Juliana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina Fil: Soto, Gabriela Cynthia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina Fil: Alleva, Karina Edith. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biologia Experimental y Aplicada; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina Fil: Jozefkowicz, Cintia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biologia Experimental y Aplicada; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina Fil: Amodeo, Gabriela. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biologia Experimental y Aplicada; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina Fil: Muschietti, Jorge Prometeo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina Fil: Ayub, Nicolás Daniel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2019-01-25T12:58:22Z 2019-01-25T12:58:22Z 2014-02 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://link.springer.com/article/10.1007/s00232-013-9618-8 http://hdl.handle.net/20.500.12123/4332 0022-2631 1432-1424 https://doi.org/10.1007/s00232-013-9618-8 eng info:eu-repo/semantics/restrictedAccess application/pdf Springer The Journal of Membrane Biology 247 (2) : 107–125 (February 2014) |
| spellingShingle | Proteínas Metabolismo Proteíco Experimentación en Laboratorio Células Eucarioticas Proteins Protein Metabolism Laboratory Experimentation Eukaryotic Cells Acuaporinas Aquaporins Perez Di Giorgio, Juliana Andrea Soto, Gabriela Cinthia Alleva, Karina Edith Jozefkowicz, Cintia Amodeo, Gabriela Muschietti, Jorge Prometeo Ayub, Nicolás Daniel Prediction of aquaporin function by integrating evolutionary and functional analyses |
| title | Prediction of aquaporin function by integrating evolutionary and functional analyses |
| title_full | Prediction of aquaporin function by integrating evolutionary and functional analyses |
| title_fullStr | Prediction of aquaporin function by integrating evolutionary and functional analyses |
| title_full_unstemmed | Prediction of aquaporin function by integrating evolutionary and functional analyses |
| title_short | Prediction of aquaporin function by integrating evolutionary and functional analyses |
| title_sort | prediction of aquaporin function by integrating evolutionary and functional analyses |
| topic | Proteínas Metabolismo Proteíco Experimentación en Laboratorio Células Eucarioticas Proteins Protein Metabolism Laboratory Experimentation Eukaryotic Cells Acuaporinas Aquaporins |
| url | https://link.springer.com/article/10.1007/s00232-013-9618-8 http://hdl.handle.net/20.500.12123/4332 https://doi.org/10.1007/s00232-013-9618-8 |
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