Peanut seed cultivars with contrasting resistance to Aspergillus parasiticus colonization display differential temporal response of protease inhibitors

Significant efforts are being made to minimize aflatoxin contamination in peanut seeds and one possible strategy is to understand and exploit the mechanisms of plant defense against fungal infection. In this study we have identified and characterized, at biochemical and molecular levels, plant prote...

Full description

Bibliographic Details
Main Authors: Muller, Virginia, Bonacci, Gustavo Roberto, Batthyany, Carlos, Amé, María Valeria, Carrari, Fernando, Gieco, Jorge Omar, Asis, Ramón
Format: info:ar-repo/semantics/artículo
Language:Inglés
Published: American Phytopathological Society 2019
Subjects:
Online Access:https://apsjournals.apsnet.org/doi/pdf/10.1094/PHYTO-09-16-0346-R
http://hdl.handle.net/20.500.12123/4322
https://doi.org/10.1094/PHYTO-09-16-0346-R
_version_ 1855035301358993408
author Muller, Virginia
Bonacci, Gustavo Roberto
Batthyany, Carlos
Amé, María Valeria
Carrari, Fernando
Gieco, Jorge Omar
Asis, Ramón
author_browse Amé, María Valeria
Asis, Ramón
Batthyany, Carlos
Bonacci, Gustavo Roberto
Carrari, Fernando
Gieco, Jorge Omar
Muller, Virginia
author_facet Muller, Virginia
Bonacci, Gustavo Roberto
Batthyany, Carlos
Amé, María Valeria
Carrari, Fernando
Gieco, Jorge Omar
Asis, Ramón
author_sort Muller, Virginia
collection INTA Digital
description Significant efforts are being made to minimize aflatoxin contamination in peanut seeds and one possible strategy is to understand and exploit the mechanisms of plant defense against fungal infection. In this study we have identified and characterized, at biochemical and molecular levels, plant protease inhibitors (PPIs) produced in peanut seeds of the resistant PI 337394 and the susceptible Forman cultivar during Aspergillus parasiticus colonization. With chromatographic methods and 2D-electrophoresis-mass spectrometry we have isolated and identified four variants of Bowman-Birk trypsin inhibitor (BBTI) and a novel Kunitz-type protease inhibitor (KPI) produced in response to A. parasiticus colonization. KPI was detected only in the resistant cultivar, while BBTI was produced in the resistant cultivar in a higher concentration than susceptible cultivar and with different isoforms. The kinetic expression of KPI and BBTI genes along with trypsin inhibitory activity was analyzed in both cultivars during infection. In the susceptible cultivar an early PPI activity response was associated with BBTI occurrence. Meanwhile, in the resistant cultivar a later response with a larger increase in PPI activity was associated with BBTI and KPI occurrence. The biological significance of PPI in seed defense against fungal infection was analyzed and linked to inhibitory properties on enzymes released by the fungus during infection, and to the antifungal effect of KPI.
format info:ar-repo/semantics/artículo
id INTA4322
institution Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina)
language Inglés
publishDate 2019
publishDateRange 2019
publishDateSort 2019
publisher American Phytopathological Society
publisherStr American Phytopathological Society
record_format dspace
spelling INTA43222019-01-24T11:54:05Z Peanut seed cultivars with contrasting resistance to Aspergillus parasiticus colonization display differential temporal response of protease inhibitors Muller, Virginia Bonacci, Gustavo Roberto Batthyany, Carlos Amé, María Valeria Carrari, Fernando Gieco, Jorge Omar Asis, Ramón Arachis hypogaea Semilla Variedades Resistencia a la Enfermedad Aspergillus parasiticus Inhibidores de Proteinasas Seeds Varieties Disease Resistance Proteinase Inhibitors Maní Inhibidores de Proteasas Protease Inhibitors Significant efforts are being made to minimize aflatoxin contamination in peanut seeds and one possible strategy is to understand and exploit the mechanisms of plant defense against fungal infection. In this study we have identified and characterized, at biochemical and molecular levels, plant protease inhibitors (PPIs) produced in peanut seeds of the resistant PI 337394 and the susceptible Forman cultivar during Aspergillus parasiticus colonization. With chromatographic methods and 2D-electrophoresis-mass spectrometry we have isolated and identified four variants of Bowman-Birk trypsin inhibitor (BBTI) and a novel Kunitz-type protease inhibitor (KPI) produced in response to A. parasiticus colonization. KPI was detected only in the resistant cultivar, while BBTI was produced in the resistant cultivar in a higher concentration than susceptible cultivar and with different isoforms. The kinetic expression of KPI and BBTI genes along with trypsin inhibitory activity was analyzed in both cultivars during infection. In the susceptible cultivar an early PPI activity response was associated with BBTI occurrence. Meanwhile, in the resistant cultivar a later response with a larger increase in PPI activity was associated with BBTI and KPI occurrence. The biological significance of PPI in seed defense against fungal infection was analyzed and linked to inhibitory properties on enzymes released by the fungus during infection, and to the antifungal effect of KPI. Instituto de Biotecnología Fil: Muller, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina Fil: Bonacci, Gustavo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina Fil: Batthyany, Carlos. Institut Pasteur de Montevideo. Unidad de Bioquímica y Proteómica Analítica; Uruguay Fil: Amé, María Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina Fil: Carrari, Fernando Oscar. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina Fil: Gieco, Jorge Omar. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Manfredi; Argentina Fil: Asis, Ramón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina 2019-01-24T11:52:53Z 2019-01-24T11:52:53Z 2017-04 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://apsjournals.apsnet.org/doi/pdf/10.1094/PHYTO-09-16-0346-R http://hdl.handle.net/20.500.12123/4322 0031-949X 1943-7684 https://doi.org/10.1094/PHYTO-09-16-0346-R eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf American Phytopathological Society Phytopathology 107 (4) : 474-482 (April 2017)
spellingShingle Arachis hypogaea
Semilla
Variedades
Resistencia a la Enfermedad
Aspergillus parasiticus
Inhibidores de Proteinasas
Seeds
Varieties
Disease Resistance
Proteinase Inhibitors
Maní
Inhibidores de Proteasas
Protease Inhibitors
Muller, Virginia
Bonacci, Gustavo Roberto
Batthyany, Carlos
Amé, María Valeria
Carrari, Fernando
Gieco, Jorge Omar
Asis, Ramón
Peanut seed cultivars with contrasting resistance to Aspergillus parasiticus colonization display differential temporal response of protease inhibitors
title Peanut seed cultivars with contrasting resistance to Aspergillus parasiticus colonization display differential temporal response of protease inhibitors
title_full Peanut seed cultivars with contrasting resistance to Aspergillus parasiticus colonization display differential temporal response of protease inhibitors
title_fullStr Peanut seed cultivars with contrasting resistance to Aspergillus parasiticus colonization display differential temporal response of protease inhibitors
title_full_unstemmed Peanut seed cultivars with contrasting resistance to Aspergillus parasiticus colonization display differential temporal response of protease inhibitors
title_short Peanut seed cultivars with contrasting resistance to Aspergillus parasiticus colonization display differential temporal response of protease inhibitors
title_sort peanut seed cultivars with contrasting resistance to aspergillus parasiticus colonization display differential temporal response of protease inhibitors
topic Arachis hypogaea
Semilla
Variedades
Resistencia a la Enfermedad
Aspergillus parasiticus
Inhibidores de Proteinasas
Seeds
Varieties
Disease Resistance
Proteinase Inhibitors
Maní
Inhibidores de Proteasas
Protease Inhibitors
url https://apsjournals.apsnet.org/doi/pdf/10.1094/PHYTO-09-16-0346-R
http://hdl.handle.net/20.500.12123/4322
https://doi.org/10.1094/PHYTO-09-16-0346-R
work_keys_str_mv AT mullervirginia peanutseedcultivarswithcontrastingresistancetoaspergillusparasiticuscolonizationdisplaydifferentialtemporalresponseofproteaseinhibitors
AT bonaccigustavoroberto peanutseedcultivarswithcontrastingresistancetoaspergillusparasiticuscolonizationdisplaydifferentialtemporalresponseofproteaseinhibitors
AT batthyanycarlos peanutseedcultivarswithcontrastingresistancetoaspergillusparasiticuscolonizationdisplaydifferentialtemporalresponseofproteaseinhibitors
AT amemariavaleria peanutseedcultivarswithcontrastingresistancetoaspergillusparasiticuscolonizationdisplaydifferentialtemporalresponseofproteaseinhibitors
AT carrarifernando peanutseedcultivarswithcontrastingresistancetoaspergillusparasiticuscolonizationdisplaydifferentialtemporalresponseofproteaseinhibitors
AT giecojorgeomar peanutseedcultivarswithcontrastingresistancetoaspergillusparasiticuscolonizationdisplaydifferentialtemporalresponseofproteaseinhibitors
AT asisramon peanutseedcultivarswithcontrastingresistancetoaspergillusparasiticuscolonizationdisplaydifferentialtemporalresponseofproteaseinhibitors