Co-inoculation of baculovirus and FMDV vaccine in mice, elicits very early protection against foot and mouth disease virus without interfering with long lasting immunity
Baculoviruses (Bvs) potentiate the immune response against soluble antigens. We investigated whether Bv could be used as immunoactivator in foot-and-mouth disease (FMD) vaccines using the BALB/c mouse model. Mice were vaccinated with a single dose of inactivated FMDV (iFMDV), iFMDV + Bv, Bv, or cult...
| Autores principales: | , , , , , |
|---|---|
| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2019
|
| Materias: | |
| Acceso en línea: | https://www.sciencedirect.com/science/article/pii/S0264410X13004131 http://hdl.handle.net/20.500.12123/4312 https://doi.org/10.1016/j.vaccine.2013.03.067 |
| _version_ | 1855035299565928448 |
|---|---|
| author | Quattrocchi, Valeria Molinari, Maria Paula Langellotti, Cecilia Ana Gnazzo, Victoria Taboga, Oscar Alberto Zamorano, Patricia Ines |
| author_browse | Gnazzo, Victoria Langellotti, Cecilia Ana Molinari, Maria Paula Quattrocchi, Valeria Taboga, Oscar Alberto Zamorano, Patricia Ines |
| author_facet | Quattrocchi, Valeria Molinari, Maria Paula Langellotti, Cecilia Ana Gnazzo, Victoria Taboga, Oscar Alberto Zamorano, Patricia Ines |
| author_sort | Quattrocchi, Valeria |
| collection | INTA Digital |
| description | Baculoviruses (Bvs) potentiate the immune response against soluble antigens. We investigated whether Bv could be used as immunoactivator in foot-and-mouth disease (FMD) vaccines using the BALB/c mouse model. Mice were vaccinated with a single dose of inactivated FMDV (iFMDV), iFMDV + Bv, Bv, or culture medium. Humoral and cellular immune responses were higher in animals immunized with iFMDV + Bv than in mice vaccinated with iFMDV alone. Animals receiving iFMDV + Bv had significantly lower viremia at 2, 4 and 7 dpv, than those immunized with iFMDV alone. In order to prolong the immune response, iFMDV oil vaccine was co-inoculated with Bv. Animals receiving iFMDV oil vaccine + Bv were protected two days earlier than those receiving the iFMDV oil vaccine alone. Both formulations protected until 14 dpv, the last day of the experiment. This is the first report in which Bv is used as an adjuvant in a FMDV vaccine. |
| format | info:ar-repo/semantics/artículo |
| id | INTA4312 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA43122019-02-19T13:58:44Z Co-inoculation of baculovirus and FMDV vaccine in mice, elicits very early protection against foot and mouth disease virus without interfering with long lasting immunity Quattrocchi, Valeria Molinari, Maria Paula Langellotti, Cecilia Ana Gnazzo, Victoria Taboga, Oscar Alberto Zamorano, Patricia Ines Virus Fiebre Aftosa Ratón Baculovirus Inoculación Vacuna Inmunidad Enfermedades de los Animales Aphthovirus Mice Inoculation Vaccines Immunity Animal Diseases Baculoviruses (Bvs) potentiate the immune response against soluble antigens. We investigated whether Bv could be used as immunoactivator in foot-and-mouth disease (FMD) vaccines using the BALB/c mouse model. Mice were vaccinated with a single dose of inactivated FMDV (iFMDV), iFMDV + Bv, Bv, or culture medium. Humoral and cellular immune responses were higher in animals immunized with iFMDV + Bv than in mice vaccinated with iFMDV alone. Animals receiving iFMDV + Bv had significantly lower viremia at 2, 4 and 7 dpv, than those immunized with iFMDV alone. In order to prolong the immune response, iFMDV oil vaccine was co-inoculated with Bv. Animals receiving iFMDV oil vaccine + Bv were protected two days earlier than those receiving the iFMDV oil vaccine alone. Both formulations protected until 14 dpv, the last day of the experiment. This is the first report in which Bv is used as an adjuvant in a FMDV vaccine. Instituto de Virología Fil: Quattrocchi, Valeria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Molinari, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Langellotti, Cecilia Ana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Gnazzo, Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Taboga, Oscar Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Zamorano, Patricia Ines. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad del Salvador; Argentina 2019-01-22T15:42:12Z 2019-01-22T15:42:12Z 2013-05-31 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.sciencedirect.com/science/article/pii/S0264410X13004131 http://hdl.handle.net/20.500.12123/4312 0264-410X https://doi.org/10.1016/j.vaccine.2013.03.067 eng info:eu-repo/semantics/restrictedAccess application/pdf Elsevier Vaccine 31 (24) : 2713-2718 (May 2013) |
| spellingShingle | Virus Fiebre Aftosa Ratón Baculovirus Inoculación Vacuna Inmunidad Enfermedades de los Animales Aphthovirus Mice Inoculation Vaccines Immunity Animal Diseases Quattrocchi, Valeria Molinari, Maria Paula Langellotti, Cecilia Ana Gnazzo, Victoria Taboga, Oscar Alberto Zamorano, Patricia Ines Co-inoculation of baculovirus and FMDV vaccine in mice, elicits very early protection against foot and mouth disease virus without interfering with long lasting immunity |
| title | Co-inoculation of baculovirus and FMDV vaccine in mice, elicits very early protection against foot and mouth disease virus without interfering with long lasting immunity |
| title_full | Co-inoculation of baculovirus and FMDV vaccine in mice, elicits very early protection against foot and mouth disease virus without interfering with long lasting immunity |
| title_fullStr | Co-inoculation of baculovirus and FMDV vaccine in mice, elicits very early protection against foot and mouth disease virus without interfering with long lasting immunity |
| title_full_unstemmed | Co-inoculation of baculovirus and FMDV vaccine in mice, elicits very early protection against foot and mouth disease virus without interfering with long lasting immunity |
| title_short | Co-inoculation of baculovirus and FMDV vaccine in mice, elicits very early protection against foot and mouth disease virus without interfering with long lasting immunity |
| title_sort | co inoculation of baculovirus and fmdv vaccine in mice elicits very early protection against foot and mouth disease virus without interfering with long lasting immunity |
| topic | Virus Fiebre Aftosa Ratón Baculovirus Inoculación Vacuna Inmunidad Enfermedades de los Animales Aphthovirus Mice Inoculation Vaccines Immunity Animal Diseases |
| url | https://www.sciencedirect.com/science/article/pii/S0264410X13004131 http://hdl.handle.net/20.500.12123/4312 https://doi.org/10.1016/j.vaccine.2013.03.067 |
| work_keys_str_mv | AT quattrocchivaleria coinoculationofbaculovirusandfmdvvaccineinmiceelicitsveryearlyprotectionagainstfootandmouthdiseaseviruswithoutinterferingwithlonglastingimmunity AT molinarimariapaula coinoculationofbaculovirusandfmdvvaccineinmiceelicitsveryearlyprotectionagainstfootandmouthdiseaseviruswithoutinterferingwithlonglastingimmunity AT langellotticeciliaana coinoculationofbaculovirusandfmdvvaccineinmiceelicitsveryearlyprotectionagainstfootandmouthdiseaseviruswithoutinterferingwithlonglastingimmunity AT gnazzovictoria coinoculationofbaculovirusandfmdvvaccineinmiceelicitsveryearlyprotectionagainstfootandmouthdiseaseviruswithoutinterferingwithlonglastingimmunity AT tabogaoscaralberto coinoculationofbaculovirusandfmdvvaccineinmiceelicitsveryearlyprotectionagainstfootandmouthdiseaseviruswithoutinterferingwithlonglastingimmunity AT zamoranopatriciaines coinoculationofbaculovirusandfmdvvaccineinmiceelicitsveryearlyprotectionagainstfootandmouthdiseaseviruswithoutinterferingwithlonglastingimmunity |