IFNG-mediated immune responses enhance autophagy against Mycobacterium tuberculosis antigens in patients with active tuberculosis
Protective immunity against Mycobacterium tuberculosis (Mtb) requires IFNG. Besides, IFNG-mediated induction of autophagy suppresses survival of virulent Mtb in macrophage cell lines. We investigated the contribution of autophagy to the defense against Mtb antigen (Mtb-Ag) in cells from tuberculosis...
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
Taylor & Francis
2019
|
| Materias: | |
| Acceso en línea: | https://www.tandfonline.com/doi/full/10.4161/15548627.2014.981791 http://hdl.handle.net/20.500.12123/4303 https://doi.org/10.4161/15548627.2014.981791 |
| _version_ | 1855483406088929280 |
|---|---|
| author | Rovetta, Ana Inés Peña, Delfina Hernández del Pino, Rodrigo Emanuel Recalde, Gabriela María Pellegrini, Joaquín Miguel Bigi, Fabiana Musella, Rosa María Palmero, Domingo Gutierrez, Marisa Colombo, Maria Isabel García, Verónica Edith |
| author_browse | Bigi, Fabiana Colombo, Maria Isabel García, Verónica Edith Gutierrez, Marisa Hernández del Pino, Rodrigo Emanuel Musella, Rosa María Palmero, Domingo Pellegrini, Joaquín Miguel Peña, Delfina Recalde, Gabriela María Rovetta, Ana Inés |
| author_facet | Rovetta, Ana Inés Peña, Delfina Hernández del Pino, Rodrigo Emanuel Recalde, Gabriela María Pellegrini, Joaquín Miguel Bigi, Fabiana Musella, Rosa María Palmero, Domingo Gutierrez, Marisa Colombo, Maria Isabel García, Verónica Edith |
| author_sort | Rovetta, Ana Inés |
| collection | INTA Digital |
| description | Protective immunity against Mycobacterium tuberculosis (Mtb) requires IFNG. Besides, IFNG-mediated induction of autophagy suppresses survival of virulent Mtb in macrophage cell lines. We investigated the contribution of autophagy to the defense against Mtb antigen (Mtb-Ag) in cells from tuberculosis patients and healthy donors (HD). Patients were classified as high responders (HR) if their T cells produced significant IFNG against Mtb-Ag; and low responders (LR) when patients showed weak or no T cell responses to Mtb-Ag. The highest autophagy levels were detected in HD cells whereas the lowest quantities were observed in LR patients. Interestingly, upon Mtb-Ag stimulation, we detected a positive correlation between IFNG and MAP1LC3B-II/LC3-II levels. Actually, blockage of Mtb-Ag-induced IFNG markedly reduced autophagy in HR patients whereas addition of limited amounts of IFNG significantly increased autophagy in LR patients. Therefore, autophagy collaborates with human immune responses against Mtb in close association with specific IFNG secreted against the pathogen. |
| format | Artículo |
| id | INTA4303 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Taylor & Francis |
| publisherStr | Taylor & Francis |
| record_format | dspace |
| spelling | INTA43032019-01-21T15:31:51Z IFNG-mediated immune responses enhance autophagy against Mycobacterium tuberculosis antigens in patients with active tuberculosis Rovetta, Ana Inés Peña, Delfina Hernández del Pino, Rodrigo Emanuel Recalde, Gabriela María Pellegrini, Joaquín Miguel Bigi, Fabiana Musella, Rosa María Palmero, Domingo Gutierrez, Marisa Colombo, Maria Isabel García, Verónica Edith Mycobacterium tuberculosis Respuesta Inmunológica Interferonas Citoquinas Antígenos Immune Response Interferons Cytokines Antigens Autofagia Autophagy Interferon Gamma Protective immunity against Mycobacterium tuberculosis (Mtb) requires IFNG. Besides, IFNG-mediated induction of autophagy suppresses survival of virulent Mtb in macrophage cell lines. We investigated the contribution of autophagy to the defense against Mtb antigen (Mtb-Ag) in cells from tuberculosis patients and healthy donors (HD). Patients were classified as high responders (HR) if their T cells produced significant IFNG against Mtb-Ag; and low responders (LR) when patients showed weak or no T cell responses to Mtb-Ag. The highest autophagy levels were detected in HD cells whereas the lowest quantities were observed in LR patients. Interestingly, upon Mtb-Ag stimulation, we detected a positive correlation between IFNG and MAP1LC3B-II/LC3-II levels. Actually, blockage of Mtb-Ag-induced IFNG markedly reduced autophagy in HR patients whereas addition of limited amounts of IFNG significantly increased autophagy in LR patients. Therefore, autophagy collaborates with human immune responses against Mtb in close association with specific IFNG secreted against the pathogen. Instituto de Biotecnología Fil: Rovetta, Ana Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina Fil: Peña, Delfina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina Fil: Hernández del Pino, Rodrigo Emanuel. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina Fil: Recalde, Gabriela María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina Fil: Pellegrini, Joaquín Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina Fil: Musella, Rosa María. Ciudad Autónoma de Buenos Aires. Hospital Muñiz. División Tisioneumonología; Argentina Fil: Palmero, Domingo. Ciudad Autónoma de Buenos Aires. Hospital Muñiz. División Tisioneumonología; Argentina Fil: Gutierrez, Marisa. Ciudad Autónoma de Buenos Aires. Hospital General de Agudos. E. Tornú. Sección Bacteriología de la Tuberculosis; Argentina Fil: Colombo, Maria Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina Fil: García, Verónica Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina 2019-01-21T15:30:19Z 2019-01-21T15:30:19Z 2014-11 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.tandfonline.com/doi/full/10.4161/15548627.2014.981791 http://hdl.handle.net/20.500.12123/4303 1554-8627 1554-8635 https://doi.org/10.4161/15548627.2014.981791 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Taylor & Francis Autophagy 10 (12) : 2109-2121 (November 2014) |
| spellingShingle | Mycobacterium tuberculosis Respuesta Inmunológica Interferonas Citoquinas Antígenos Immune Response Interferons Cytokines Antigens Autofagia Autophagy Interferon Gamma Rovetta, Ana Inés Peña, Delfina Hernández del Pino, Rodrigo Emanuel Recalde, Gabriela María Pellegrini, Joaquín Miguel Bigi, Fabiana Musella, Rosa María Palmero, Domingo Gutierrez, Marisa Colombo, Maria Isabel García, Verónica Edith IFNG-mediated immune responses enhance autophagy against Mycobacterium tuberculosis antigens in patients with active tuberculosis |
| title | IFNG-mediated immune responses enhance autophagy against Mycobacterium tuberculosis antigens in patients with active tuberculosis |
| title_full | IFNG-mediated immune responses enhance autophagy against Mycobacterium tuberculosis antigens in patients with active tuberculosis |
| title_fullStr | IFNG-mediated immune responses enhance autophagy against Mycobacterium tuberculosis antigens in patients with active tuberculosis |
| title_full_unstemmed | IFNG-mediated immune responses enhance autophagy against Mycobacterium tuberculosis antigens in patients with active tuberculosis |
| title_short | IFNG-mediated immune responses enhance autophagy against Mycobacterium tuberculosis antigens in patients with active tuberculosis |
| title_sort | ifng mediated immune responses enhance autophagy against mycobacterium tuberculosis antigens in patients with active tuberculosis |
| topic | Mycobacterium tuberculosis Respuesta Inmunológica Interferonas Citoquinas Antígenos Immune Response Interferons Cytokines Antigens Autofagia Autophagy Interferon Gamma |
| url | https://www.tandfonline.com/doi/full/10.4161/15548627.2014.981791 http://hdl.handle.net/20.500.12123/4303 https://doi.org/10.4161/15548627.2014.981791 |
| work_keys_str_mv | AT rovettaanaines ifngmediatedimmuneresponsesenhanceautophagyagainstmycobacteriumtuberculosisantigensinpatientswithactivetuberculosis AT penadelfina ifngmediatedimmuneresponsesenhanceautophagyagainstmycobacteriumtuberculosisantigensinpatientswithactivetuberculosis AT hernandezdelpinorodrigoemanuel ifngmediatedimmuneresponsesenhanceautophagyagainstmycobacteriumtuberculosisantigensinpatientswithactivetuberculosis AT recaldegabrielamaria ifngmediatedimmuneresponsesenhanceautophagyagainstmycobacteriumtuberculosisantigensinpatientswithactivetuberculosis AT pellegrinijoaquinmiguel ifngmediatedimmuneresponsesenhanceautophagyagainstmycobacteriumtuberculosisantigensinpatientswithactivetuberculosis AT bigifabiana ifngmediatedimmuneresponsesenhanceautophagyagainstmycobacteriumtuberculosisantigensinpatientswithactivetuberculosis AT musellarosamaria ifngmediatedimmuneresponsesenhanceautophagyagainstmycobacteriumtuberculosisantigensinpatientswithactivetuberculosis AT palmerodomingo ifngmediatedimmuneresponsesenhanceautophagyagainstmycobacteriumtuberculosisantigensinpatientswithactivetuberculosis AT gutierrezmarisa ifngmediatedimmuneresponsesenhanceautophagyagainstmycobacteriumtuberculosisantigensinpatientswithactivetuberculosis AT colombomariaisabel ifngmediatedimmuneresponsesenhanceautophagyagainstmycobacteriumtuberculosisantigensinpatientswithactivetuberculosis AT garciaveronicaedith ifngmediatedimmuneresponsesenhanceautophagyagainstmycobacteriumtuberculosisantigensinpatientswithactivetuberculosis |