Virulence factors of the Mycobacterium tuberculosis complex
The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that cause tuberculosis in both humans and animals. This illness, still today, remains to be one of the leading causes of morbidity and mortality throughout the world. The mycobacteria enter the host by air, and, once...
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| Format: | info:ar-repo/semantics/artículo |
| Language: | Inglés |
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Taylor & Francis
2019
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| Online Access: | https://www.tandfonline.com/doi/full/10.4161/viru.22329 http://hdl.handle.net/20.500.12123/4293 https://doi.org/10.4161/viru.22329 |
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| author | Forrellad, Marina Andrea Klepp, Laura Ines Gioffre, Andrea Sabio y Garcia, Julia Veronica Morbidoni, Hector R. Santangelo, María De La Paz Cataldi, Angel Adrian Bigi, Fabiana |
| author_browse | Bigi, Fabiana Cataldi, Angel Adrian Forrellad, Marina Andrea Gioffre, Andrea Klepp, Laura Ines Morbidoni, Hector R. Sabio y Garcia, Julia Veronica Santangelo, María De La Paz |
| author_facet | Forrellad, Marina Andrea Klepp, Laura Ines Gioffre, Andrea Sabio y Garcia, Julia Veronica Morbidoni, Hector R. Santangelo, María De La Paz Cataldi, Angel Adrian Bigi, Fabiana |
| author_sort | Forrellad, Marina Andrea |
| collection | INTA Digital |
| description | The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that cause tuberculosis in both humans and animals. This illness, still today, remains to be one of the leading causes of morbidity and mortality throughout the world. The mycobacteria enter the host by air, and, once in the lungs, are phagocytated by macrophages. This may lead to the rapid elimination of the bacillus or to the triggering of an active tuberculosis infection. A large number of different virulence factors have evolved in MTBC members as a response to the host immune reaction. The aim of this review is to describe the bacterial genes/proteins that are essential for the virulence of MTBC species, and that have been demonstrated in an in vivo model of infection. Knowledge of MTBC virulence factors is essential for the development of new vaccines and drugs to help manage the disease toward an increasingly more tuberculosis-free world. |
| format | info:ar-repo/semantics/artículo |
| id | INTA4293 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Taylor & Francis |
| publisherStr | Taylor & Francis |
| record_format | dspace |
| spelling | INTA42932019-01-18T13:21:50Z Virulence factors of the Mycobacterium tuberculosis complex Forrellad, Marina Andrea Klepp, Laura Ines Gioffre, Andrea Sabio y Garcia, Julia Veronica Morbidoni, Hector R. Santangelo, María De La Paz Cataldi, Angel Adrian Bigi, Fabiana Mycobacterium tuberculosis Virulencia Patogenicidad Control de Enfermedades Vacuna Virulence Pathogenicity Disease Control Vaccines The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that cause tuberculosis in both humans and animals. This illness, still today, remains to be one of the leading causes of morbidity and mortality throughout the world. The mycobacteria enter the host by air, and, once in the lungs, are phagocytated by macrophages. This may lead to the rapid elimination of the bacillus or to the triggering of an active tuberculosis infection. A large number of different virulence factors have evolved in MTBC members as a response to the host immune reaction. The aim of this review is to describe the bacterial genes/proteins that are essential for the virulence of MTBC species, and that have been demonstrated in an in vivo model of infection. Knowledge of MTBC virulence factors is essential for the development of new vaccines and drugs to help manage the disease toward an increasingly more tuberculosis-free world. Instituto de Biotecnología Fil: Forrellad, Marina Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina Fil: Klepp, Laura Ines. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina Fil: Gioffre, Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina Fil: Sabio y Garcia, Julia Veronica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina Fil: Morbidoni, Hector R. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Cátedra de Microbiología; Argentina Fil: Santangelo, María De La Paz. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. Fil: Cataldi, Angel Adrian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina 2019-01-18T13:20:36Z 2019-01-18T13:20:36Z 2013-01 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.tandfonline.com/doi/full/10.4161/viru.22329 http://hdl.handle.net/20.500.12123/4293 2150-5594 2150-5608 https://doi.org/10.4161/viru.22329 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Taylor & Francis Virulence 4 (1) : 3-66 (2013) |
| spellingShingle | Mycobacterium tuberculosis Virulencia Patogenicidad Control de Enfermedades Vacuna Virulence Pathogenicity Disease Control Vaccines Forrellad, Marina Andrea Klepp, Laura Ines Gioffre, Andrea Sabio y Garcia, Julia Veronica Morbidoni, Hector R. Santangelo, María De La Paz Cataldi, Angel Adrian Bigi, Fabiana Virulence factors of the Mycobacterium tuberculosis complex |
| title | Virulence factors of the Mycobacterium tuberculosis complex |
| title_full | Virulence factors of the Mycobacterium tuberculosis complex |
| title_fullStr | Virulence factors of the Mycobacterium tuberculosis complex |
| title_full_unstemmed | Virulence factors of the Mycobacterium tuberculosis complex |
| title_short | Virulence factors of the Mycobacterium tuberculosis complex |
| title_sort | virulence factors of the mycobacterium tuberculosis complex |
| topic | Mycobacterium tuberculosis Virulencia Patogenicidad Control de Enfermedades Vacuna Virulence Pathogenicity Disease Control Vaccines |
| url | https://www.tandfonline.com/doi/full/10.4161/viru.22329 http://hdl.handle.net/20.500.12123/4293 https://doi.org/10.4161/viru.22329 |
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