Inflammatory infiltration into placentas of Neospora caninum challenged cattle correlates with clinical outcome of pregnancy
Infection with Neospora caninum stimulates host cell-mediated immune responses, which may be responsible for placental damage leading to bovine abortion. The aim of this study was to compare immune responses in the bovine placenta, following experimental infection in different stages of pregnancy. P...
| Autores principales: | , , , , , , , , , , , |
|---|---|
| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
| Publicado: |
BMC
2018
|
| Materias: | |
| Acceso en línea: | https://veterinaryresearch.biomedcentral.com/articles/10.1186/1297-9716-45-11 http://hdl.handle.net/20.500.12123/4002 https://doi.org/10.1186/1297-9716-45-11 |
| _version_ | 1855035242649223168 |
|---|---|
| author | Canton, German Jose Katzer, Frank Maley, Stephen W. Bartley, Paul M. Benavides-Silván, Julio Palarea-Albaladejo, Javier Pang, Yvonne Smith, Sionagh Rocchi, Mara Buxton, David Innes, Elisabeth A. Chianini, Francesca |
| author_browse | Bartley, Paul M. Benavides-Silván, Julio Buxton, David Canton, German Jose Chianini, Francesca Innes, Elisabeth A. Katzer, Frank Maley, Stephen W. Palarea-Albaladejo, Javier Pang, Yvonne Rocchi, Mara Smith, Sionagh |
| author_facet | Canton, German Jose Katzer, Frank Maley, Stephen W. Bartley, Paul M. Benavides-Silván, Julio Palarea-Albaladejo, Javier Pang, Yvonne Smith, Sionagh Rocchi, Mara Buxton, David Innes, Elisabeth A. Chianini, Francesca |
| author_sort | Canton, German Jose |
| collection | INTA Digital |
| description | Infection with Neospora caninum stimulates host cell-mediated immune responses, which may be responsible for placental damage leading to bovine abortion. The aim of this study was to compare immune responses in the bovine placenta, following experimental infection in different stages of pregnancy. Placentomes were examined by immunohistochemistry and inflammation in early gestation was generally moderate to severe, particularly in the placentas carrying non-viable foetuses, whereas it was milder in later stages, mainly characterised by the presence of CD3+, CD4+ and γδ T-cells. This distinctive cellular immune response may explain the milder clinical outcome observed when animals are infected in later gestation. |
| format | info:ar-repo/semantics/artículo |
| id | INTA4002 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| publisher | BMC |
| publisherStr | BMC |
| record_format | dspace |
| spelling | INTA40022019-01-31T13:20:38Z Inflammatory infiltration into placentas of Neospora caninum challenged cattle correlates with clinical outcome of pregnancy Canton, German Jose Katzer, Frank Maley, Stephen W. Bartley, Paul M. Benavides-Silván, Julio Palarea-Albaladejo, Javier Pang, Yvonne Smith, Sionagh Rocchi, Mara Buxton, David Innes, Elisabeth A. Chianini, Francesca Neospora caninum Ganado Bovino Enfermedades de los Animales Placenta Inflamación Gestación Cattle Animal Diseases Inflammation Pregnancy Infection with Neospora caninum stimulates host cell-mediated immune responses, which may be responsible for placental damage leading to bovine abortion. The aim of this study was to compare immune responses in the bovine placenta, following experimental infection in different stages of pregnancy. Placentomes were examined by immunohistochemistry and inflammation in early gestation was generally moderate to severe, particularly in the placentas carrying non-viable foetuses, whereas it was milder in later stages, mainly characterised by the presence of CD3+, CD4+ and γδ T-cells. This distinctive cellular immune response may explain the milder clinical outcome observed when animals are infected in later gestation. EEA Balcarce Fil: Canton, German Jose. Moredun Research Institute; Reino Unido. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina Fil: Katzer, Frank. Moredun Research Institute; Reino Unido Fil: Maley, Stephen W. Moredun Research Institute; Reino Unido Fil: Bartley, Paul M. Moredun Research Institute; Reino Unido Fil: Benavides-Silván, Julio. Moredun Research Institute; Reino Unido. Consejo Superior de Investigaciones Científicas. Instituto de Ganadería de Montaña; España Fil: Palarea-Albaladejo, Javier. Biomathematics & Statistics Scotland; Reino Unido Fil: Pang, Yvonne. Moredun Research Institute; Reino Unido Fil: Smith, Sionagh. University of Edinburgh. Royal (Dick) School of Veterinary Studies and Roslin Institute; Reino Unido Fil: Rocchi, Mara. Moredun Research Institute; Reino Unido Fil: Buxton, David. Moredun Research Institute; Reino Unido Fil: Innes, Elisabeth A. Moredun Research Institute; Reino Unido Fil: Chianini, Francesca. Moredun Research Institute; Reino Unido 2018-12-03T17:46:10Z 2018-12-03T17:46:10Z 2014-01 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://veterinaryresearch.biomedcentral.com/articles/10.1186/1297-9716-45-11 http://hdl.handle.net/20.500.12123/4002 0928-4249 1297-9716 https://doi.org/10.1186/1297-9716-45-11 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf BMC Veterinary Research 45 : 11 (2014) |
| spellingShingle | Neospora caninum Ganado Bovino Enfermedades de los Animales Placenta Inflamación Gestación Cattle Animal Diseases Inflammation Pregnancy Canton, German Jose Katzer, Frank Maley, Stephen W. Bartley, Paul M. Benavides-Silván, Julio Palarea-Albaladejo, Javier Pang, Yvonne Smith, Sionagh Rocchi, Mara Buxton, David Innes, Elisabeth A. Chianini, Francesca Inflammatory infiltration into placentas of Neospora caninum challenged cattle correlates with clinical outcome of pregnancy |
| title | Inflammatory infiltration into placentas of Neospora caninum challenged cattle correlates with clinical outcome of pregnancy |
| title_full | Inflammatory infiltration into placentas of Neospora caninum challenged cattle correlates with clinical outcome of pregnancy |
| title_fullStr | Inflammatory infiltration into placentas of Neospora caninum challenged cattle correlates with clinical outcome of pregnancy |
| title_full_unstemmed | Inflammatory infiltration into placentas of Neospora caninum challenged cattle correlates with clinical outcome of pregnancy |
| title_short | Inflammatory infiltration into placentas of Neospora caninum challenged cattle correlates with clinical outcome of pregnancy |
| title_sort | inflammatory infiltration into placentas of neospora caninum challenged cattle correlates with clinical outcome of pregnancy |
| topic | Neospora caninum Ganado Bovino Enfermedades de los Animales Placenta Inflamación Gestación Cattle Animal Diseases Inflammation Pregnancy |
| url | https://veterinaryresearch.biomedcentral.com/articles/10.1186/1297-9716-45-11 http://hdl.handle.net/20.500.12123/4002 https://doi.org/10.1186/1297-9716-45-11 |
| work_keys_str_mv | AT cantongermanjose inflammatoryinfiltrationintoplacentasofneosporacaninumchallengedcattlecorrelateswithclinicaloutcomeofpregnancy AT katzerfrank inflammatoryinfiltrationintoplacentasofneosporacaninumchallengedcattlecorrelateswithclinicaloutcomeofpregnancy AT maleystephenw inflammatoryinfiltrationintoplacentasofneosporacaninumchallengedcattlecorrelateswithclinicaloutcomeofpregnancy AT bartleypaulm inflammatoryinfiltrationintoplacentasofneosporacaninumchallengedcattlecorrelateswithclinicaloutcomeofpregnancy AT benavidessilvanjulio inflammatoryinfiltrationintoplacentasofneosporacaninumchallengedcattlecorrelateswithclinicaloutcomeofpregnancy AT palareaalbaladejojavier inflammatoryinfiltrationintoplacentasofneosporacaninumchallengedcattlecorrelateswithclinicaloutcomeofpregnancy AT pangyvonne inflammatoryinfiltrationintoplacentasofneosporacaninumchallengedcattlecorrelateswithclinicaloutcomeofpregnancy AT smithsionagh inflammatoryinfiltrationintoplacentasofneosporacaninumchallengedcattlecorrelateswithclinicaloutcomeofpregnancy AT rocchimara inflammatoryinfiltrationintoplacentasofneosporacaninumchallengedcattlecorrelateswithclinicaloutcomeofpregnancy AT buxtondavid inflammatoryinfiltrationintoplacentasofneosporacaninumchallengedcattlecorrelateswithclinicaloutcomeofpregnancy AT inneselisabetha inflammatoryinfiltrationintoplacentasofneosporacaninumchallengedcattlecorrelateswithclinicaloutcomeofpregnancy AT chianinifrancesca inflammatoryinfiltrationintoplacentasofneosporacaninumchallengedcattlecorrelateswithclinicaloutcomeofpregnancy |