Lactobacillus fermentum CRL1446 Ameliorates Oxidative and Metabolic Parameters by Increasing Intestinal Feruloyl Esterase Activity and Modulating Microbiota in Caloric-Restricted Mice

The purpose of this study was to determine whether the administration of the feruloyl esterase (FE)-producing strain Lactobacillus fermentum CRL1446 enhances metabolic and oxidative parameters in caloric-restricted (CR) mice. Balb/c male mice were divided into ad libitum fed Group (ALF Group), CR di...

Descripción completa

Detalles Bibliográficos
Autores principales: Russo, Matias Irineo, Fabersani Marrades, Mario Emanuel, Abeijon Mukdsi, Maria Claudia, Ross, Gloria Romina, Fontana, Cecilia Alejandra, Benítez Páez, Alfonso, Gauffin Cano, María Paola, Medina, Roxana Beatriz
Formato: info:ar-repo/semantics/artículo
Lenguaje:Inglés
Publicado: 2018
Materias:
Acceso en línea:https://www.mdpi.com/2072-6643/8/7/415
http://hdl.handle.net/20.500.12123/3762
https://doi.org/10.3390/nu8070415
_version_ 1855035198919409664
author Russo, Matias Irineo
Fabersani Marrades, Mario Emanuel
Abeijon Mukdsi, Maria Claudia
Ross, Gloria Romina
Fontana, Cecilia Alejandra
Benítez Páez, Alfonso
Gauffin Cano, María Paola
Medina, Roxana Beatriz
author_browse Abeijon Mukdsi, Maria Claudia
Benítez Páez, Alfonso
Fabersani Marrades, Mario Emanuel
Fontana, Cecilia Alejandra
Gauffin Cano, María Paola
Medina, Roxana Beatriz
Ross, Gloria Romina
Russo, Matias Irineo
author_facet Russo, Matias Irineo
Fabersani Marrades, Mario Emanuel
Abeijon Mukdsi, Maria Claudia
Ross, Gloria Romina
Fontana, Cecilia Alejandra
Benítez Páez, Alfonso
Gauffin Cano, María Paola
Medina, Roxana Beatriz
author_sort Russo, Matias Irineo
collection INTA Digital
description The purpose of this study was to determine whether the administration of the feruloyl esterase (FE)-producing strain Lactobacillus fermentum CRL1446 enhances metabolic and oxidative parameters in caloric-restricted (CR) mice. Balb/c male mice were divided into ad libitum fed Group (ALF Group), CR diet Group (CR Group) and CR diet plus L. fermentum Group (CR-Lf Group). CR diet was administered during 45 days and CRL1446 strain was given in the dose of 108 cells/mL/day/mouse. FE activity was determined in intestinal mucosa and content at Day 1, 20 and 45. Triglyceride, total cholesterol, glucose, thiobarbituric acid reactive substances (TBARS) levels and glutathione reductase activity were determined in plasma. Gut microbiota was evaluated by high-throughput sequencing of 16S rRNA gene amplicons. At Day 45, total intestinal FE activity in CR-Lf Group was higher (p = 0.020) than in CR and ALF groups and an improvement in both metabolic (reductions in triglyceride (p = 0.0025), total cholesterol (p = 0.005) and glucose (p < 0.0001) levels) and oxidative (decrease of TBARS levels and increase of plasmatic glutathione reductase activity (p = 0.006)) parameters was observed, compared to ALF Group. CR diet increased abundance of Bacteroidetes and CRL1446 administration increased abundance of Bifidobacterium and Lactobacillus genus. L. fermentun CRL1446 exerted a bifidogenic effect under CR conditions.
format info:ar-repo/semantics/artículo
id INTA3762
institution Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina)
language Inglés
publishDate 2018
publishDateRange 2018
publishDateSort 2018
record_format dspace
spelling INTA37622018-11-01T16:55:16Z Lactobacillus fermentum CRL1446 Ameliorates Oxidative and Metabolic Parameters by Increasing Intestinal Feruloyl Esterase Activity and Modulating Microbiota in Caloric-Restricted Mice Russo, Matias Irineo Fabersani Marrades, Mario Emanuel Abeijon Mukdsi, Maria Claudia Ross, Gloria Romina Fontana, Cecilia Alejandra Benítez Páez, Alfonso Gauffin Cano, María Paola Medina, Roxana Beatriz Lactobacillus fermentum Ratón Dieta Flora Microbiana Metabolismo Mice Diet Microbial Flora Metabolism Microbiota Feruloyl esterasa The purpose of this study was to determine whether the administration of the feruloyl esterase (FE)-producing strain Lactobacillus fermentum CRL1446 enhances metabolic and oxidative parameters in caloric-restricted (CR) mice. Balb/c male mice were divided into ad libitum fed Group (ALF Group), CR diet Group (CR Group) and CR diet plus L. fermentum Group (CR-Lf Group). CR diet was administered during 45 days and CRL1446 strain was given in the dose of 108 cells/mL/day/mouse. FE activity was determined in intestinal mucosa and content at Day 1, 20 and 45. Triglyceride, total cholesterol, glucose, thiobarbituric acid reactive substances (TBARS) levels and glutathione reductase activity were determined in plasma. Gut microbiota was evaluated by high-throughput sequencing of 16S rRNA gene amplicons. At Day 45, total intestinal FE activity in CR-Lf Group was higher (p = 0.020) than in CR and ALF groups and an improvement in both metabolic (reductions in triglyceride (p = 0.0025), total cholesterol (p = 0.005) and glucose (p < 0.0001) levels) and oxidative (decrease of TBARS levels and increase of plasmatic glutathione reductase activity (p = 0.006)) parameters was observed, compared to ALF Group. CR diet increased abundance of Bacteroidetes and CRL1446 administration increased abundance of Bifidobacterium and Lactobacillus genus. L. fermentun CRL1446 exerted a bifidogenic effect under CR conditions. EEA Famaillá Fil: Russo, Matias Irineo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina Fil: Fabersani Marrades, Mario Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina Fil: Abeijon Mukdsi, Maria Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina. Universidad del Norte Santo Tomás de Aquino. Facultad de Ciencias de la Salud; Argentina Fil: Ross, Gloria Romina. Universidad del Norte Santo Tomás de Aquino. Facultad de Ciencias de la Salud; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina Fil: Fontana, Cecilia Alejandra. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Famaillá; Argentina Fil: Benítez Páez, Alfonso. Consejo Superior de Investigaciones Científicas. Instituto de Agroquímica y Tecnología de Alimentos. Microbial Ecology, Nutrition & Health Laboratory; España Fil: Gauffin Cano, María Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina. Universidad del Norte Santo Tomás de Aquino. Facultad de Ciencias de la Salud; Argentina Fil: Medina, Roxana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina 2018-11-01T16:53:53Z 2018-11-01T16:53:53Z 2016 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.mdpi.com/2072-6643/8/7/415 http://hdl.handle.net/20.500.12123/3762 2072-6643 https://doi.org/10.3390/nu8070415 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Nutrients 8 (7) : 415 (2016)
spellingShingle Lactobacillus fermentum
Ratón
Dieta
Flora Microbiana
Metabolismo
Mice
Diet
Microbial Flora
Metabolism
Microbiota
Feruloyl esterasa
Russo, Matias Irineo
Fabersani Marrades, Mario Emanuel
Abeijon Mukdsi, Maria Claudia
Ross, Gloria Romina
Fontana, Cecilia Alejandra
Benítez Páez, Alfonso
Gauffin Cano, María Paola
Medina, Roxana Beatriz
Lactobacillus fermentum CRL1446 Ameliorates Oxidative and Metabolic Parameters by Increasing Intestinal Feruloyl Esterase Activity and Modulating Microbiota in Caloric-Restricted Mice
title Lactobacillus fermentum CRL1446 Ameliorates Oxidative and Metabolic Parameters by Increasing Intestinal Feruloyl Esterase Activity and Modulating Microbiota in Caloric-Restricted Mice
title_full Lactobacillus fermentum CRL1446 Ameliorates Oxidative and Metabolic Parameters by Increasing Intestinal Feruloyl Esterase Activity and Modulating Microbiota in Caloric-Restricted Mice
title_fullStr Lactobacillus fermentum CRL1446 Ameliorates Oxidative and Metabolic Parameters by Increasing Intestinal Feruloyl Esterase Activity and Modulating Microbiota in Caloric-Restricted Mice
title_full_unstemmed Lactobacillus fermentum CRL1446 Ameliorates Oxidative and Metabolic Parameters by Increasing Intestinal Feruloyl Esterase Activity and Modulating Microbiota in Caloric-Restricted Mice
title_short Lactobacillus fermentum CRL1446 Ameliorates Oxidative and Metabolic Parameters by Increasing Intestinal Feruloyl Esterase Activity and Modulating Microbiota in Caloric-Restricted Mice
title_sort lactobacillus fermentum crl1446 ameliorates oxidative and metabolic parameters by increasing intestinal feruloyl esterase activity and modulating microbiota in caloric restricted mice
topic Lactobacillus fermentum
Ratón
Dieta
Flora Microbiana
Metabolismo
Mice
Diet
Microbial Flora
Metabolism
Microbiota
Feruloyl esterasa
url https://www.mdpi.com/2072-6643/8/7/415
http://hdl.handle.net/20.500.12123/3762
https://doi.org/10.3390/nu8070415
work_keys_str_mv AT russomatiasirineo lactobacillusfermentumcrl1446amelioratesoxidativeandmetabolicparametersbyincreasingintestinalferuloylesteraseactivityandmodulatingmicrobiotaincaloricrestrictedmice
AT fabersanimarradesmarioemanuel lactobacillusfermentumcrl1446amelioratesoxidativeandmetabolicparametersbyincreasingintestinalferuloylesteraseactivityandmodulatingmicrobiotaincaloricrestrictedmice
AT abeijonmukdsimariaclaudia lactobacillusfermentumcrl1446amelioratesoxidativeandmetabolicparametersbyincreasingintestinalferuloylesteraseactivityandmodulatingmicrobiotaincaloricrestrictedmice
AT rossgloriaromina lactobacillusfermentumcrl1446amelioratesoxidativeandmetabolicparametersbyincreasingintestinalferuloylesteraseactivityandmodulatingmicrobiotaincaloricrestrictedmice
AT fontanaceciliaalejandra lactobacillusfermentumcrl1446amelioratesoxidativeandmetabolicparametersbyincreasingintestinalferuloylesteraseactivityandmodulatingmicrobiotaincaloricrestrictedmice
AT benitezpaezalfonso lactobacillusfermentumcrl1446amelioratesoxidativeandmetabolicparametersbyincreasingintestinalferuloylesteraseactivityandmodulatingmicrobiotaincaloricrestrictedmice
AT gauffincanomariapaola lactobacillusfermentumcrl1446amelioratesoxidativeandmetabolicparametersbyincreasingintestinalferuloylesteraseactivityandmodulatingmicrobiotaincaloricrestrictedmice
AT medinaroxanabeatriz lactobacillusfermentumcrl1446amelioratesoxidativeandmetabolicparametersbyincreasingintestinalferuloylesteraseactivityandmodulatingmicrobiotaincaloricrestrictedmice