First retrospective studies with etiological confirmation of porcine transmissible gastroenteritis virus infection in Argentina
Background: In 2014, a notification of porcine transmissible gastroenteritis virus (TGEV) was made by the National Services of Animal Health of Argentina (SENASA) to the World Organization of Animal Health (OIE). The notification was based on a serological diagnosis in a small farm with a morbidity...
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
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2018
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| Acceso en línea: | https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-018-1615-9 http://hdl.handle.net/20.500.12123/3606 https://doi.org/10.1186/s12917-018-1615-9 |
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| author | Piñeyro, Pablo Enrique Lozada, Maria Ines Alarcón, Laura Valeria Sanguinetti, Ramon Cappuccio, Javier Alejandro Pérez, Estefanía Marisol Vannucci, Fabio Armocida, Alberto Madson, Darin Michael Perfumo, Carlos Juan Quiroga, Maria Alejandra |
| author_browse | Alarcón, Laura Valeria Armocida, Alberto Cappuccio, Javier Alejandro Lozada, Maria Ines Madson, Darin Michael Perfumo, Carlos Juan Piñeyro, Pablo Enrique Pérez, Estefanía Marisol Quiroga, Maria Alejandra Sanguinetti, Ramon Vannucci, Fabio |
| author_facet | Piñeyro, Pablo Enrique Lozada, Maria Ines Alarcón, Laura Valeria Sanguinetti, Ramon Cappuccio, Javier Alejandro Pérez, Estefanía Marisol Vannucci, Fabio Armocida, Alberto Madson, Darin Michael Perfumo, Carlos Juan Quiroga, Maria Alejandra |
| author_sort | Piñeyro, Pablo Enrique |
| collection | INTA Digital |
| description | Background: In 2014, a notification of porcine transmissible gastroenteritis virus (TGEV) was made by the National Services of Animal Health of Argentina (SENASA) to the World Organization of Animal Health (OIE). The notification was based on a serological diagnosis in a small farm with a morbidity rate of 2.3% without enteric clinical signs. In order to determine if TGEV was circulating before the official report, a retrospective study on cases of neonatal diarrhea was performed. The selection criteria was a sudden increase in mortality in 1- to 21-day-old piglets with watery diarrhea that did not respond to antibiotics. Based on these criteria, three clinical cases were identified during 2010–2015.
Results: All animals that were evaluated presented histological lesions consistent with enteric viral infection. The feces and ultrathin sections of intestine that were evaluated by electron microscopy confirmed the presence of round particles of approximately 80 nm in size and characterized by finely granular electrodense nucleoids consistent with complete particles of coronavirus. The presence of the TGEV antigen was confirmed by monoclonal specific immunohistochemistry, and final confirmation of a metabolically-active virus was performed by in situ hybridization to detect a TGE mRNA encoding spike protein. All sections evaluated in this case were negative for PEDV and rotavirus A.
Conclusions: This is the first case series describing neonatal mortality with etiological confirmation of TGEV in Argentina. The clinical diagnosis of TGEV infections in endemic regions is challenging due to the epidemiological distribution and coinfection with other enteric pathogens that mask the clinical presentation. |
| format | info:ar-repo/semantics/artículo |
| id | INTA3606 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| record_format | dspace |
| spelling | INTA36062018-10-17T11:55:05Z First retrospective studies with etiological confirmation of porcine transmissible gastroenteritis virus infection in Argentina Piñeyro, Pablo Enrique Lozada, Maria Ines Alarcón, Laura Valeria Sanguinetti, Ramon Cappuccio, Javier Alejandro Pérez, Estefanía Marisol Vannucci, Fabio Armocida, Alberto Madson, Darin Michael Perfumo, Carlos Juan Quiroga, Maria Alejandra Enfermedades de los Animales Virus de los Animales Cerdo Gastroenteritis Etiología Lechón Animal Diseases Animal Viruses Swine Aetiology Piglets Argentina Background: In 2014, a notification of porcine transmissible gastroenteritis virus (TGEV) was made by the National Services of Animal Health of Argentina (SENASA) to the World Organization of Animal Health (OIE). The notification was based on a serological diagnosis in a small farm with a morbidity rate of 2.3% without enteric clinical signs. In order to determine if TGEV was circulating before the official report, a retrospective study on cases of neonatal diarrhea was performed. The selection criteria was a sudden increase in mortality in 1- to 21-day-old piglets with watery diarrhea that did not respond to antibiotics. Based on these criteria, three clinical cases were identified during 2010–2015. Results: All animals that were evaluated presented histological lesions consistent with enteric viral infection. The feces and ultrathin sections of intestine that were evaluated by electron microscopy confirmed the presence of round particles of approximately 80 nm in size and characterized by finely granular electrodense nucleoids consistent with complete particles of coronavirus. The presence of the TGEV antigen was confirmed by monoclonal specific immunohistochemistry, and final confirmation of a metabolically-active virus was performed by in situ hybridization to detect a TGE mRNA encoding spike protein. All sections evaluated in this case were negative for PEDV and rotavirus A. Conclusions: This is the first case series describing neonatal mortality with etiological confirmation of TGEV in Argentina. The clinical diagnosis of TGEV infections in endemic regions is challenging due to the epidemiological distribution and coinfection with other enteric pathogens that mask the clinical presentation. EEA Marcos Juárez Fil: Piñeyro, Pablo Enrique. Iowa State University. Veterinary Medicine. Veterinary Diagnostic Laboratory; Estados Unidos Fil: Lozada, María Inés. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Patología. Laboratorio de Patología Especial Veterinaria; Argentina Fil: Alarcón, Laura Valeria. HIPRA Argentina; Argentina Fil: Sanguinetti, Ramon. Servicio Nacional de Sanidad y Calidad Agroalimentaria (SENASA). Dirección de Laboratorios y Control Técnico; Argentina Fil: Cappuccio, Javier Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Marcos Juárez; Argentina. Fil: Pérez, Estefanía Marisol. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Patología. Laboratorio de Patología Especial Veterinaria; Argentina Fil: Vannucci, Fabio. University of Minnesota. Veterinary Diagnostic Laboratory; Estados Unidos Fil: Armocida, Alberto. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Patología. Laboratorio de Patología Especial Veterinaria; Argentina Fil: Madson, Darin Michael. Iowa State University. Veterinary Medicine. Veterinary Diagnostic Laboratory; Estados Unidos Fil: Perfumo, Carlos Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Patología. Laboratorio de Patología Especial Veterinaria; Argentina Fil: Quiroga, María Alejandra. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Patología. Laboratorio de Patología Especial Veterinaria; Argentina 2018-10-17T11:53:13Z 2018-10-17T11:53:13Z 2018-09-24 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-018-1615-9 http://hdl.handle.net/20.500.12123/3606 1746-6148 https://doi.org/10.1186/s12917-018-1615-9 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf BMC Veterinary Research 14 : 292 (2018) |
| spellingShingle | Enfermedades de los Animales Virus de los Animales Cerdo Gastroenteritis Etiología Lechón Animal Diseases Animal Viruses Swine Aetiology Piglets Argentina Piñeyro, Pablo Enrique Lozada, Maria Ines Alarcón, Laura Valeria Sanguinetti, Ramon Cappuccio, Javier Alejandro Pérez, Estefanía Marisol Vannucci, Fabio Armocida, Alberto Madson, Darin Michael Perfumo, Carlos Juan Quiroga, Maria Alejandra First retrospective studies with etiological confirmation of porcine transmissible gastroenteritis virus infection in Argentina |
| title | First retrospective studies with etiological confirmation of porcine transmissible gastroenteritis virus infection in Argentina |
| title_full | First retrospective studies with etiological confirmation of porcine transmissible gastroenteritis virus infection in Argentina |
| title_fullStr | First retrospective studies with etiological confirmation of porcine transmissible gastroenteritis virus infection in Argentina |
| title_full_unstemmed | First retrospective studies with etiological confirmation of porcine transmissible gastroenteritis virus infection in Argentina |
| title_short | First retrospective studies with etiological confirmation of porcine transmissible gastroenteritis virus infection in Argentina |
| title_sort | first retrospective studies with etiological confirmation of porcine transmissible gastroenteritis virus infection in argentina |
| topic | Enfermedades de los Animales Virus de los Animales Cerdo Gastroenteritis Etiología Lechón Animal Diseases Animal Viruses Swine Aetiology Piglets Argentina |
| url | https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-018-1615-9 http://hdl.handle.net/20.500.12123/3606 https://doi.org/10.1186/s12917-018-1615-9 |
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