Dynamics of perinatal bovine leukemia virus infection
Bovine leukemia virus (BLV) is highly endemic in many countries, including Argentina. As prevention of the spread from infected animals is of primary importance in breaking the cycle of BLV transmission, it is important to know the pathophysiology of BLV infection in young animals, as they are the m...
| Autores principales: | , , , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
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BioMed Central
2018
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/3583 https://bmcvetres.biomedcentral.com/articles/10.1186/1746-6148-10-82 https://doi.org/10.1186/1746-6148-10-82 |
| _version_ | 1855035167689670656 |
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| author | Gutierrez, Gerónimo Alvarez, Irene Merlini, Ramiro Rondelli, Flavia Trono, Karina Gabriela |
| author_browse | Alvarez, Irene Gutierrez, Gerónimo Merlini, Ramiro Rondelli, Flavia Trono, Karina Gabriela |
| author_facet | Gutierrez, Gerónimo Alvarez, Irene Merlini, Ramiro Rondelli, Flavia Trono, Karina Gabriela |
| author_sort | Gutierrez, Gerónimo |
| collection | INTA Digital |
| description | Bovine leukemia virus (BLV) is highly endemic in many countries, including Argentina. As prevention of the spread from infected animals is of primary importance in breaking the cycle of BLV transmission, it is important to know the pathophysiology of BLV infection in young animals, as they are the main source of animal movement. In this work, we determined the proviral load and antibody titers of infected newborn calves from birth to first parturition (36 months).
Results:
All calves under study were born to infected dams with high proviral load (PVL) in blood and high antibody titers and detectable provirus in the colostrum. The PVL for five out of seven calves was low at birth. All animals reached PVLs of more than 1% infected peripheral blood mononuclear cells (PBMCs), three at 3 months, one at 6 months, and one at 12 months. High PVLs persisted until the end of the study, and, in two animals, exceeded one BLV copy per cell. Two other calves maintained a high PVL from birth until the end of the study. Antibody titers were 32 or higher in the first sample from six out of seven calves. These decayed at 3–6 months to 16 or lower, and then increased again after this point.
Conclusions:
Calves infected during the first week of life could play an active role in early propagation of BLV to susceptible animals, since their PVL raised up during the first 12 months and persist as high for years. Early elimination could help to prevent transmission to young susceptible animals and to their own offspring. To our knowledge, this is the first study of the kinetics of BLV proviral load and antibody titers in newborn infected calves. |
| format | info:ar-repo/semantics/artículo |
| id | INTA3583 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| publisher | BioMed Central |
| publisherStr | BioMed Central |
| record_format | dspace |
| spelling | INTA35832018-10-11T18:44:04Z Dynamics of perinatal bovine leukemia virus infection Gutierrez, Gerónimo Alvarez, Irene Merlini, Ramiro Rondelli, Flavia Trono, Karina Gabriela Bovine Leukaemia Virus Virus Leucemia Bovina Calves Ternero Anticuerpos Antibodies Parturition Parto Infection Infección Nacimiento Birth Perinatal infection Infección Perinatal Proviral Load Carga Proviral Bovine leukemia virus (BLV) is highly endemic in many countries, including Argentina. As prevention of the spread from infected animals is of primary importance in breaking the cycle of BLV transmission, it is important to know the pathophysiology of BLV infection in young animals, as they are the main source of animal movement. In this work, we determined the proviral load and antibody titers of infected newborn calves from birth to first parturition (36 months). Results: All calves under study were born to infected dams with high proviral load (PVL) in blood and high antibody titers and detectable provirus in the colostrum. The PVL for five out of seven calves was low at birth. All animals reached PVLs of more than 1% infected peripheral blood mononuclear cells (PBMCs), three at 3 months, one at 6 months, and one at 12 months. High PVLs persisted until the end of the study, and, in two animals, exceeded one BLV copy per cell. Two other calves maintained a high PVL from birth until the end of the study. Antibody titers were 32 or higher in the first sample from six out of seven calves. These decayed at 3–6 months to 16 or lower, and then increased again after this point. Conclusions: Calves infected during the first week of life could play an active role in early propagation of BLV to susceptible animals, since their PVL raised up during the first 12 months and persist as high for years. Early elimination could help to prevent transmission to young susceptible animals and to their own offspring. To our knowledge, this is the first study of the kinetics of BLV proviral load and antibody titers in newborn infected calves. Instituto de Virología Fil: Gutierrez, Gerónimo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Alvarez, Irene. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Merlini, Ramiro. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Rondelli, Flavia. Universidad Nacional de Rosario. Facultad de Ciencias Veterinarias. Cátedra de Inmunología; Argentina Fil: Trono, Karina Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina 2018-10-11T18:37:41Z 2018-10-11T18:37:41Z 2014 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/3583 https://bmcvetres.biomedcentral.com/articles/10.1186/1746-6148-10-82 1746-6148 https://doi.org/10.1186/1746-6148-10-82 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf BioMed Central BMC veterinary research 10 : 82. (2014) |
| spellingShingle | Bovine Leukaemia Virus Virus Leucemia Bovina Calves Ternero Anticuerpos Antibodies Parturition Parto Infection Infección Nacimiento Birth Perinatal infection Infección Perinatal Proviral Load Carga Proviral Gutierrez, Gerónimo Alvarez, Irene Merlini, Ramiro Rondelli, Flavia Trono, Karina Gabriela Dynamics of perinatal bovine leukemia virus infection |
| title | Dynamics of perinatal bovine leukemia virus infection |
| title_full | Dynamics of perinatal bovine leukemia virus infection |
| title_fullStr | Dynamics of perinatal bovine leukemia virus infection |
| title_full_unstemmed | Dynamics of perinatal bovine leukemia virus infection |
| title_short | Dynamics of perinatal bovine leukemia virus infection |
| title_sort | dynamics of perinatal bovine leukemia virus infection |
| topic | Bovine Leukaemia Virus Virus Leucemia Bovina Calves Ternero Anticuerpos Antibodies Parturition Parto Infection Infección Nacimiento Birth Perinatal infection Infección Perinatal Proviral Load Carga Proviral |
| url | http://hdl.handle.net/20.500.12123/3583 https://bmcvetres.biomedcentral.com/articles/10.1186/1746-6148-10-82 https://doi.org/10.1186/1746-6148-10-82 |
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