Comparative histopathological and immunological study of two field strains of chicken anemia virus
Infection of poultry with chicken anemia virus (CAV) is implicated in several field problems in broiler flocks due to the immunosuppression generated and, consequently, the increased susceptibility to secondary infections. Recently, we have reported an increased occurrence of clinical cases caused b...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
| Publicado: |
BioMed Central
2018
|
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/3582 https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-014-0102-y https://doi.org/10.1186/s13567-014-0102-y |
| _version_ | 1855035167514558464 |
|---|---|
| author | Rimondi, Agustina Pinto, Silvina Olivera, Valeria Soledad Dibarbora, Marina Perez Filgueira, Daniel Mariano Craig, María Isabel Pereda, Ariel Julian |
| author_browse | Craig, María Isabel Dibarbora, Marina Olivera, Valeria Soledad Pereda, Ariel Julian Perez Filgueira, Daniel Mariano Pinto, Silvina Rimondi, Agustina |
| author_facet | Rimondi, Agustina Pinto, Silvina Olivera, Valeria Soledad Dibarbora, Marina Perez Filgueira, Daniel Mariano Craig, María Isabel Pereda, Ariel Julian |
| author_sort | Rimondi, Agustina |
| collection | INTA Digital |
| description | Infection of poultry with chicken anemia virus (CAV) is implicated in several field problems in broiler flocks due to the immunosuppression generated and, consequently, the increased susceptibility to secondary infections. Recently, we have reported an increased occurrence of clinical cases caused by CAV strains distantly related to those commonly used for vaccination. In order to understand the behavior of two Argentinean CAV strains (CAV-10 and CAV-18) in two-week-old chickens, an immune and histopathological study was performed. Neither mortality nor clinical signs were observed in the infected or control groups. Thymus lobes from chickens infected with both CAV viruses were smaller compared to the negative control group. At 14 days post-infection (dpi), only chickens inoculated with CAV-10 show a severe depletion of lymphocytes in the thymus cortex and in follicles from the bursa of Fabricius. Also thymopoiesis disorders, such as reduction in the percentage of total DP (CD4 + CD8α+) thymocytes and alteration in the percentages of DP subpopulations, were more important in animals inoculated with the CAV-10 than the CAV-18 strain. In addition, only animals infected with CAV-10 show a decrease in CD8αβ splenocytes. Altogether our results show that, although both Argentinean CAV strains produce subclinical infections in chickens causing immunosuppression at 14 dpi, they might differ in their in vivo pathogenicity. |
| format | info:ar-repo/semantics/artículo |
| id | INTA3582 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| publisher | BioMed Central |
| publisherStr | BioMed Central |
| record_format | dspace |
| spelling | INTA35822018-10-11T18:36:35Z Comparative histopathological and immunological study of two field strains of chicken anemia virus Rimondi, Agustina Pinto, Silvina Olivera, Valeria Soledad Dibarbora, Marina Perez Filgueira, Daniel Mariano Craig, María Isabel Pereda, Ariel Julian Chicken Anemia Virus Chickens Animal Diseases Histocytological Analysis Análisis Histocitológico Histopathology Infection Virus Anemia Pollo Pollo Enfermedades de los Animales Histopatología Infección Subclinical Infection Double Positive Cell Negative Control Group Argentina Infection of poultry with chicken anemia virus (CAV) is implicated in several field problems in broiler flocks due to the immunosuppression generated and, consequently, the increased susceptibility to secondary infections. Recently, we have reported an increased occurrence of clinical cases caused by CAV strains distantly related to those commonly used for vaccination. In order to understand the behavior of two Argentinean CAV strains (CAV-10 and CAV-18) in two-week-old chickens, an immune and histopathological study was performed. Neither mortality nor clinical signs were observed in the infected or control groups. Thymus lobes from chickens infected with both CAV viruses were smaller compared to the negative control group. At 14 days post-infection (dpi), only chickens inoculated with CAV-10 show a severe depletion of lymphocytes in the thymus cortex and in follicles from the bursa of Fabricius. Also thymopoiesis disorders, such as reduction in the percentage of total DP (CD4 + CD8α+) thymocytes and alteration in the percentages of DP subpopulations, were more important in animals inoculated with the CAV-10 than the CAV-18 strain. In addition, only animals infected with CAV-10 show a decrease in CD8αβ splenocytes. Altogether our results show that, although both Argentinean CAV strains produce subclinical infections in chickens causing immunosuppression at 14 dpi, they might differ in their in vivo pathogenicity. Instituto de Virología Fil: Rimondi, Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina Fil: Pinto, Silvina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Patología Aviar; Argentina Fil: Olivera, Valeria Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina Fil: Dibarbora, Marina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina Fil: Perez Filgueira, Daniel Mariano. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina Fil: Craig, María Isabel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina Fil: Pereda, Ariel Julian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina 2018-10-11T17:36:56Z 2018-10-11T17:36:56Z 2014-10 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/3582 https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-014-0102-y 1297-9716 https://doi.org/10.1186/s13567-014-0102-y eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf BioMed Central BMC veterinary research 45 : 102. (2014) |
| spellingShingle | Chicken Anemia Virus Chickens Animal Diseases Histocytological Analysis Análisis Histocitológico Histopathology Infection Virus Anemia Pollo Pollo Enfermedades de los Animales Histopatología Infección Subclinical Infection Double Positive Cell Negative Control Group Argentina Rimondi, Agustina Pinto, Silvina Olivera, Valeria Soledad Dibarbora, Marina Perez Filgueira, Daniel Mariano Craig, María Isabel Pereda, Ariel Julian Comparative histopathological and immunological study of two field strains of chicken anemia virus |
| title | Comparative histopathological and immunological study of two field strains of chicken anemia virus |
| title_full | Comparative histopathological and immunological study of two field strains of chicken anemia virus |
| title_fullStr | Comparative histopathological and immunological study of two field strains of chicken anemia virus |
| title_full_unstemmed | Comparative histopathological and immunological study of two field strains of chicken anemia virus |
| title_short | Comparative histopathological and immunological study of two field strains of chicken anemia virus |
| title_sort | comparative histopathological and immunological study of two field strains of chicken anemia virus |
| topic | Chicken Anemia Virus Chickens Animal Diseases Histocytological Analysis Análisis Histocitológico Histopathology Infection Virus Anemia Pollo Pollo Enfermedades de los Animales Histopatología Infección Subclinical Infection Double Positive Cell Negative Control Group Argentina |
| url | http://hdl.handle.net/20.500.12123/3582 https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-014-0102-y https://doi.org/10.1186/s13567-014-0102-y |
| work_keys_str_mv | AT rimondiagustina comparativehistopathologicalandimmunologicalstudyoftwofieldstrainsofchickenanemiavirus AT pintosilvina comparativehistopathologicalandimmunologicalstudyoftwofieldstrainsofchickenanemiavirus AT oliveravaleriasoledad comparativehistopathologicalandimmunologicalstudyoftwofieldstrainsofchickenanemiavirus AT dibarboramarina comparativehistopathologicalandimmunologicalstudyoftwofieldstrainsofchickenanemiavirus AT perezfilgueiradanielmariano comparativehistopathologicalandimmunologicalstudyoftwofieldstrainsofchickenanemiavirus AT craigmariaisabel comparativehistopathologicalandimmunologicalstudyoftwofieldstrainsofchickenanemiavirus AT peredaarieljulian comparativehistopathologicalandimmunologicalstudyoftwofieldstrainsofchickenanemiavirus |