Serology and longevity of immunity against Echinococcus granulosus in sheep and llama induced by an oil‐based EG95 vaccine
An oil‐based formulation of the EG95 vaccine to protect grazing animals against infection with Echinococcus granulosus was formulated in Argentina. The efficacy of the vaccine was monitored by serology in sheep and llama (Lama glama) and was compared to the serology in sheep previously published usi...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Artículo |
| Language: | Inglés |
| Published: |
2018
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| Online Access: | https://onlinelibrary.wiley.com/doi/abs/10.1111/pim.12325 http://hdl.handle.net/20.500.12123/2946 https://doi.org/10.1111/pim.12325 |
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| author | Poggio, Thelma Veronica Jensen, Oscar Mossello, M. Iriarte, J. Avila, Héctor Gabriel Gertiser, María Laura Serafino, J.J. Romero, Sandra Raquel Echenique, Marcelo Alejandro Dominguez, D.E. Barrios, J.R. Heath, D. |
| author_browse | Avila, Héctor Gabriel Barrios, J.R. Dominguez, D.E. Echenique, Marcelo Alejandro Gertiser, María Laura Heath, D. Iriarte, J. Jensen, Oscar Mossello, M. Poggio, Thelma Veronica Romero, Sandra Raquel Serafino, J.J. |
| author_facet | Poggio, Thelma Veronica Jensen, Oscar Mossello, M. Iriarte, J. Avila, Héctor Gabriel Gertiser, María Laura Serafino, J.J. Romero, Sandra Raquel Echenique, Marcelo Alejandro Dominguez, D.E. Barrios, J.R. Heath, D. |
| author_sort | Poggio, Thelma Veronica |
| collection | INTA Digital |
| description | An oil‐based formulation of the EG95 vaccine to protect grazing animals against infection with Echinococcus granulosus was formulated in Argentina. The efficacy of the vaccine was monitored by serology in sheep and llama (Lama glama) and was compared to the serology in sheep previously published using a QuilA‐adjuvanted vaccine. Long‐term efficacy was also tested in sheep by challenging with E. granulosus eggs of the G1 strain 4 years after the beginning of the trial. The serological results for both sheep and llama were similar to those described previously, except that there was a more rapid response after the first vaccination. A third vaccination given after 1 year resulted in a transient boost in serology that lasted for about 12 months, which was similar to results previously described. Sheep challenged after 4 years with three vaccinations presented 84·2% reduction of live cysts counts compared with control group, and after a fourth vaccination prior to challenge, this reduction was 94·7%. The oil‐based vaccine appeared to be bio‐equivalent to the QuilA vaccine. |
| format | Artículo |
| id | INTA2946 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| record_format | dspace |
| spelling | INTA29462018-08-01T17:26:40Z Serology and longevity of immunity against Echinococcus granulosus in sheep and llama induced by an oil‐based EG95 vaccine Poggio, Thelma Veronica Jensen, Oscar Mossello, M. Iriarte, J. Avila, Héctor Gabriel Gertiser, María Laura Serafino, J.J. Romero, Sandra Raquel Echenique, Marcelo Alejandro Dominguez, D.E. Barrios, J.R. Heath, D. Ovinos Llama Echinococcus granulosus Inmunidad Vacuna Serología Sheep Llamas Immunity Vaccines Serology An oil‐based formulation of the EG95 vaccine to protect grazing animals against infection with Echinococcus granulosus was formulated in Argentina. The efficacy of the vaccine was monitored by serology in sheep and llama (Lama glama) and was compared to the serology in sheep previously published using a QuilA‐adjuvanted vaccine. Long‐term efficacy was also tested in sheep by challenging with E. granulosus eggs of the G1 strain 4 years after the beginning of the trial. The serological results for both sheep and llama were similar to those described previously, except that there was a more rapid response after the first vaccination. A third vaccination given after 1 year resulted in a transient boost in serology that lasted for about 12 months, which was similar to results previously described. Sheep challenged after 4 years with three vaccinations presented 84·2% reduction of live cysts counts compared with control group, and after a fourth vaccination prior to challenge, this reduction was 94·7%. The oil‐based vaccine appeared to be bio‐equivalent to the QuilA vaccine. EEA Abra Pampa Fil: Poggio, Thelma Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología. Centro de Virologia Animal; Argentina Fil: Jensen, Oscar. Centro de Investigacion en Zoonosis; Argentina Fil: Mossello, M.. Gobierno de la Provincia de Chubut. Ministerio de Salud. Departamento Zooantroponosis; Argentina Fil: Iriarte, J. Gobierno de la Provincia de Chubut. Ministerio de Salud. Departamento Zooantroponosis; Argentina Fil: Avila, Héctor Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina Fil: Gertiser, María Laura. Centro de Investigacion en Zoonosis; Argentina Fil: Serafino, J.J. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología. Centro de Virologia Animal; Argentina Fil: Romero, Sandra Raquel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Abra Pampa; Argentina Fil: Echenique, Marcelo Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Abra Pampa; Argentina Fil: Dominguez, D. E.. Gobierno de la Provincia de Chubut. Ministerio de Desarrollo Territorial y Sectores Productivos. Subsecretaría de Ganadería y Agricultura. Dirección de Sanidad Animal; Argentina Fil: Barrios, J.R.. Servicio Nacional de Sanidad Animal (SENASA).cDirección de Sanidad Animal. Oficina Local Puerto Madryn; Argentina Fil: Heath, D.. AgResearch; Nueva Zelanda 2018-08-01T17:24:07Z 2018-08-01T17:24:07Z 2016-08 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://onlinelibrary.wiley.com/doi/abs/10.1111/pim.12325 http://hdl.handle.net/20.500.12123/2946 0141-9838 1365-3024 https://doi.org/10.1111/pim.12325 eng info:eu-repo/semantics/restrictedAccess application/pdf Parasite Immunology 38 (8) : 496-502 (August 2016) |
| spellingShingle | Ovinos Llama Echinococcus granulosus Inmunidad Vacuna Serología Sheep Llamas Immunity Vaccines Serology Poggio, Thelma Veronica Jensen, Oscar Mossello, M. Iriarte, J. Avila, Héctor Gabriel Gertiser, María Laura Serafino, J.J. Romero, Sandra Raquel Echenique, Marcelo Alejandro Dominguez, D.E. Barrios, J.R. Heath, D. Serology and longevity of immunity against Echinococcus granulosus in sheep and llama induced by an oil‐based EG95 vaccine |
| title | Serology and longevity of immunity against Echinococcus granulosus in sheep and llama induced by an oil‐based EG95 vaccine |
| title_full | Serology and longevity of immunity against Echinococcus granulosus in sheep and llama induced by an oil‐based EG95 vaccine |
| title_fullStr | Serology and longevity of immunity against Echinococcus granulosus in sheep and llama induced by an oil‐based EG95 vaccine |
| title_full_unstemmed | Serology and longevity of immunity against Echinococcus granulosus in sheep and llama induced by an oil‐based EG95 vaccine |
| title_short | Serology and longevity of immunity against Echinococcus granulosus in sheep and llama induced by an oil‐based EG95 vaccine |
| title_sort | serology and longevity of immunity against echinococcus granulosus in sheep and llama induced by an oil based eg95 vaccine |
| topic | Ovinos Llama Echinococcus granulosus Inmunidad Vacuna Serología Sheep Llamas Immunity Vaccines Serology |
| url | https://onlinelibrary.wiley.com/doi/abs/10.1111/pim.12325 http://hdl.handle.net/20.500.12123/2946 https://doi.org/10.1111/pim.12325 |
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