Mitigated clinical disease in water buffaloes experimentally infected with Babesia bovis
Water buffaloes (Bubalus bubalis) are raised in tropical and subtropical regions of the world, and act as hosts of Babesia bovis parasites and the tick vector Rhipicephalus microplus. As no clinical cases of B. bovis-infection have been reported, we hypothesized that, unlike bovines, water buffaloes...
| Autores principales: | , , , , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.sciencedirect.com/science/article/pii/S1877959X1830075X http://hdl.handle.net/20.500.12123/2873 https://doi.org/10.1016/j.ttbdis.2018.04.012 |
| _version_ | 1855035042438316032 |
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| author | Benitez, Daniel Francisco Mesplet, Maria Echaide, Ignacio Eduardo Torioni, Susana Marta Schnittger, Leonhard Florin-Christensen, Mónica |
| author_browse | Benitez, Daniel Francisco Echaide, Ignacio Eduardo Florin-Christensen, Mónica Mesplet, Maria Schnittger, Leonhard Torioni, Susana Marta |
| author_facet | Benitez, Daniel Francisco Mesplet, Maria Echaide, Ignacio Eduardo Torioni, Susana Marta Schnittger, Leonhard Florin-Christensen, Mónica |
| author_sort | Benitez, Daniel Francisco |
| collection | INTA Digital |
| description | Water buffaloes (Bubalus bubalis) are raised in tropical and subtropical regions of the world, and act as hosts of Babesia bovis parasites and the tick vector Rhipicephalus microplus. As no clinical cases of B. bovis-infection have been reported, we hypothesized that, unlike bovines, water buffaloes respond asymptomatically to an acute infection. To test this hypothesis, we inoculated two groups of 24-month-old Mediterranean breed water buffaloes with 108 erythrocytes infected with two Argentine B. bovis isolates: BboM2P (n = 5) or BboS2P (n = 5). These strains displayed mild (BboM2P) or high (BboS2P) pathogenicity in Bos taurus calves of the same age (n = 5 and n = 1, respectively), when tested in parallel. In water buffaloes, no changes in body temperature were observed with both strains, and no hematocrit changes were detected in BboM2P-inoculated animals. In contrast, in the BboS2P-inoculated water buffalo group significant but relatively minor reductions in haematocrit values were noted compared to the infected bovine. The parasitemia attained in water buffaloes was considerably lower than in bovines and could only be detected by nested PCR, or indirectly via serology, whereas in most bovines, it could also be detected in Giemsa-stained smears under the light microscope. Our results show that water buffaloes present no or significantly mitigated clinical symptoms to B. bovis infections and suggest that they are able to substantially reduce and/or eliminate B. bovis parasites from circulation by an efficient innate immune mechanism. |
| format | info:ar-repo/semantics/artículo |
| id | INTA2873 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| record_format | dspace |
| spelling | INTA28732018-07-25T14:08:28Z Mitigated clinical disease in water buffaloes experimentally infected with Babesia bovis Benitez, Daniel Francisco Mesplet, Maria Echaide, Ignacio Eduardo Torioni, Susana Marta Schnittger, Leonhard Florin-Christensen, Mónica Búfalo de Agua Plagas de Animales Babesia bovis Babesiosis Enfermedades de los Animales Water Buffaloes Pests of Animals Animal Diseases Garrapatas Water buffaloes (Bubalus bubalis) are raised in tropical and subtropical regions of the world, and act as hosts of Babesia bovis parasites and the tick vector Rhipicephalus microplus. As no clinical cases of B. bovis-infection have been reported, we hypothesized that, unlike bovines, water buffaloes respond asymptomatically to an acute infection. To test this hypothesis, we inoculated two groups of 24-month-old Mediterranean breed water buffaloes with 108 erythrocytes infected with two Argentine B. bovis isolates: BboM2P (n = 5) or BboS2P (n = 5). These strains displayed mild (BboM2P) or high (BboS2P) pathogenicity in Bos taurus calves of the same age (n = 5 and n = 1, respectively), when tested in parallel. In water buffaloes, no changes in body temperature were observed with both strains, and no hematocrit changes were detected in BboM2P-inoculated animals. In contrast, in the BboS2P-inoculated water buffalo group significant but relatively minor reductions in haematocrit values were noted compared to the infected bovine. The parasitemia attained in water buffaloes was considerably lower than in bovines and could only be detected by nested PCR, or indirectly via serology, whereas in most bovines, it could also be detected in Giemsa-stained smears under the light microscope. Our results show that water buffaloes present no or significantly mitigated clinical symptoms to B. bovis infections and suggest that they are able to substantially reduce and/or eliminate B. bovis parasites from circulation by an efficient innate immune mechanism. EEA Mercedes Fil: Benitez, Daniel Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; Argentina Fil: Mesplet, Maria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina Fil: Echaide, Ignacio Eduardo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina Fil: Torioni, Susana Marta. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina Fil: Schnittger, Leonhard. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Florin-Christensen, Mónica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2018-07-25T14:06:18Z 2018-07-25T14:06:18Z 2018-07 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.sciencedirect.com/science/article/pii/S1877959X1830075X http://hdl.handle.net/20.500.12123/2873 1877-959X 1877-9603 https://doi.org/10.1016/j.ttbdis.2018.04.012 eng info:eu-repo/semantics/restrictedAccess application/pdf Ticks and Tick-borne Diseases 9 (5) : 1358-1363 (July 2018) |
| spellingShingle | Búfalo de Agua Plagas de Animales Babesia bovis Babesiosis Enfermedades de los Animales Water Buffaloes Pests of Animals Animal Diseases Garrapatas Benitez, Daniel Francisco Mesplet, Maria Echaide, Ignacio Eduardo Torioni, Susana Marta Schnittger, Leonhard Florin-Christensen, Mónica Mitigated clinical disease in water buffaloes experimentally infected with Babesia bovis |
| title | Mitigated clinical disease in water buffaloes experimentally infected with Babesia bovis |
| title_full | Mitigated clinical disease in water buffaloes experimentally infected with Babesia bovis |
| title_fullStr | Mitigated clinical disease in water buffaloes experimentally infected with Babesia bovis |
| title_full_unstemmed | Mitigated clinical disease in water buffaloes experimentally infected with Babesia bovis |
| title_short | Mitigated clinical disease in water buffaloes experimentally infected with Babesia bovis |
| title_sort | mitigated clinical disease in water buffaloes experimentally infected with babesia bovis |
| topic | Búfalo de Agua Plagas de Animales Babesia bovis Babesiosis Enfermedades de los Animales Water Buffaloes Pests of Animals Animal Diseases Garrapatas |
| url | https://www.sciencedirect.com/science/article/pii/S1877959X1830075X http://hdl.handle.net/20.500.12123/2873 https://doi.org/10.1016/j.ttbdis.2018.04.012 |
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