Which are important targets in development of S. aureus mastitis vaccine?
Staphylococcus aureus represents one of the leading causes of mastitis in dairy cows worldwide. S. aureus IMI have variable outcomes due to virulence of the strain involved, immune defenses of the host, and by antibiotic resistance. The difficulty in eradication and the increasing concerns on antibi...
| Main Authors: | , , , , |
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| Format: | Artículo |
| Language: | Inglés |
| Published: |
2018
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| Online Access: | https://www.sciencedirect.com/science/article/pii/S0034528815000934?via%3Dihub http://hdl.handle.net/20.500.12123/2825 https://doi.org/10.1016/j.rvsc.2015.03.019 |
| _version_ | 1855483127280959488 |
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| author | Scali, F. Camussone, Cecilia Calvinho, Luis Fernando Cipolla, M. Zecconi, A. |
| author_browse | Calvinho, Luis Fernando Camussone, Cecilia Cipolla, M. Scali, F. Zecconi, A. |
| author_facet | Scali, F. Camussone, Cecilia Calvinho, Luis Fernando Cipolla, M. Zecconi, A. |
| author_sort | Scali, F. |
| collection | INTA Digital |
| description | Staphylococcus aureus represents one of the leading causes of mastitis in dairy cows worldwide. S. aureus IMI have variable outcomes due to virulence of the strain involved, immune defenses of the host, and by antibiotic resistance. The difficulty in eradication and the increasing concerns on antibiotics usages underscore the interest in developing new tools to control S. aureus mastitis. Vaccination represents one of the most studied of these tools but, so far, no vaccine seems to provide reliable protection. This review summarizes current knowledge on the major vaccine targets, including surface proteins, capsular polysaccharides, biofilm, and toxins. Finally, the present status of vaccination against S. aureus and the future of vaccine design were discussed, including how differences among in vivo models may influence vaccines development. |
| format | Artículo |
| id | INTA2825 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| record_format | dspace |
| spelling | INTA28252018-07-19T13:48:25Z Which are important targets in development of S. aureus mastitis vaccine? Scali, F. Camussone, Cecilia Calvinho, Luis Fernando Cipolla, M. Zecconi, A. Mastítis Bovina Enfermedades de los Animales Ganado Bovino Control de Enfermedades Vacuna Staphylococcus aureus Bovine Mastitis Animal Diseases Cattle Disease Control Vaccines Staphylococcus aureus represents one of the leading causes of mastitis in dairy cows worldwide. S. aureus IMI have variable outcomes due to virulence of the strain involved, immune defenses of the host, and by antibiotic resistance. The difficulty in eradication and the increasing concerns on antibiotics usages underscore the interest in developing new tools to control S. aureus mastitis. Vaccination represents one of the most studied of these tools but, so far, no vaccine seems to provide reliable protection. This review summarizes current knowledge on the major vaccine targets, including surface proteins, capsular polysaccharides, biofilm, and toxins. Finally, the present status of vaccination against S. aureus and the future of vaccine design were discussed, including how differences among in vivo models may influence vaccines development. EEA Rafaela Fil: Scali, F. Universita Degli Studi Di Milano. Department of Veterinary Sciences and Public Health; Italia Fil: Camussone, Cecilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fil: Calvinho, Luis Fernando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina Fil: Cipolla, M. Universita Degli Studi Di Milano. Department of Veterinary Sciences and Public Health; Italia Fil: Zecconi, A. Universita Degli Studi Di Milano. Department of Veterinary Sciences and Public Health; Italia 2018-07-19T13:46:49Z 2018-07-19T13:46:49Z 2015-06 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.sciencedirect.com/science/article/pii/S0034528815000934?via%3Dihub http://hdl.handle.net/20.500.12123/2825 0034-5288 https://doi.org/10.1016/j.rvsc.2015.03.019 eng info:eu-repo/semantics/restrictedAccess application/pdf Research in Veterinary Science 100 : 88-99 (June 2015) |
| spellingShingle | Mastítis Bovina Enfermedades de los Animales Ganado Bovino Control de Enfermedades Vacuna Staphylococcus aureus Bovine Mastitis Animal Diseases Cattle Disease Control Vaccines Scali, F. Camussone, Cecilia Calvinho, Luis Fernando Cipolla, M. Zecconi, A. Which are important targets in development of S. aureus mastitis vaccine? |
| title | Which are important targets in development of S. aureus mastitis vaccine? |
| title_full | Which are important targets in development of S. aureus mastitis vaccine? |
| title_fullStr | Which are important targets in development of S. aureus mastitis vaccine? |
| title_full_unstemmed | Which are important targets in development of S. aureus mastitis vaccine? |
| title_short | Which are important targets in development of S. aureus mastitis vaccine? |
| title_sort | which are important targets in development of s aureus mastitis vaccine |
| topic | Mastítis Bovina Enfermedades de los Animales Ganado Bovino Control de Enfermedades Vacuna Staphylococcus aureus Bovine Mastitis Animal Diseases Cattle Disease Control Vaccines |
| url | https://www.sciencedirect.com/science/article/pii/S0034528815000934?via%3Dihub http://hdl.handle.net/20.500.12123/2825 https://doi.org/10.1016/j.rvsc.2015.03.019 |
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