Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattle
The prevention and control of bovine mastitis by enhancing natural defenses in animals is important to improve the quality of dairy products. Mastitis resistance is a complex trait which depends on genetic components, as well as environmental and physiological factors. The limitations of classical c...
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| Format: | info:ar-repo/semantics/artículo |
| Language: | Inglés |
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2018
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| Online Access: | https://link.springer.com/article/10.1007%2Fs13353-015-0278-5 http://hdl.handle.net/20.500.12123/2823 https://doi.org/10.1007/s13353-015-0278-5 |
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| author | Nani, Juan Pablo Raschia, Maria Agustina Carignano, Hugo Poli, Mario Andres Calvinho, Luis Fernando Amadio, Ariel |
| author_browse | Amadio, Ariel Calvinho, Luis Fernando Carignano, Hugo Nani, Juan Pablo Poli, Mario Andres Raschia, Maria Agustina |
| author_facet | Nani, Juan Pablo Raschia, Maria Agustina Carignano, Hugo Poli, Mario Andres Calvinho, Luis Fernando Amadio, Ariel |
| author_sort | Nani, Juan Pablo |
| collection | INTA Digital |
| description | The prevention and control of bovine mastitis by enhancing natural defenses in animals is important to improve the quality of dairy products. Mastitis resistance is a complex trait which depends on genetic components, as well as environmental and physiological factors. The limitations of classical control measures have led to the search for alternative approaches to minimize the use of antibiotics by selecting naturally resistant animals. Polymorphisms in genes associated with the innate immune system are strong candidates to be evaluated as genetic markers. In this work, we evaluated a set of single nucleotide polymorphisms (SNPs) in candidate genes for health and production traits, and determined their association with the somatic cell score (SCS) as an indicator of mastitis in Argentinean dairy cattle. We evaluated 941 cows: Holstein (n = 677) and Holstein × Jersey (n = 264) crossbred, daughters from 22 bulls from 14 dairy farms located in the central dairy area of Argentina. Two of the 21 successfully genotyped markers were found to be significantly associated (p < 0.05) with the SCS: GHR_140 and OPN_8514C-T. The heterozygote genotype for GHR_140 showed a favorable effect in reducing the SCS. On the other hand, heterozygote genotypes for OPN8514C-T caused an increase in the SCS; moreover, combined genotypes for OPN SNPs showed an even larger effect. These findings can contribute to the design of effective marker-assisted selection programs. |
| format | info:ar-repo/semantics/artículo |
| id | INTA2823 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| record_format | dspace |
| spelling | INTA28232018-07-19T13:03:07Z Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattle Nani, Juan Pablo Raschia, Maria Agustina Carignano, Hugo Poli, Mario Andres Calvinho, Luis Fernando Amadio, Ariel Ganado de Leche Control de Enfermedades Enfermedades de los Animales Mastítis Bovina Genes Células Somáticas Dairy Cattle Disease Control Animal Diseases Bovine Mastitis Somatic Cells Argentina The prevention and control of bovine mastitis by enhancing natural defenses in animals is important to improve the quality of dairy products. Mastitis resistance is a complex trait which depends on genetic components, as well as environmental and physiological factors. The limitations of classical control measures have led to the search for alternative approaches to minimize the use of antibiotics by selecting naturally resistant animals. Polymorphisms in genes associated with the innate immune system are strong candidates to be evaluated as genetic markers. In this work, we evaluated a set of single nucleotide polymorphisms (SNPs) in candidate genes for health and production traits, and determined their association with the somatic cell score (SCS) as an indicator of mastitis in Argentinean dairy cattle. We evaluated 941 cows: Holstein (n = 677) and Holstein × Jersey (n = 264) crossbred, daughters from 22 bulls from 14 dairy farms located in the central dairy area of Argentina. Two of the 21 successfully genotyped markers were found to be significantly associated (p < 0.05) with the SCS: GHR_140 and OPN_8514C-T. The heterozygote genotype for GHR_140 showed a favorable effect in reducing the SCS. On the other hand, heterozygote genotypes for OPN8514C-T caused an increase in the SCS; moreover, combined genotypes for OPN SNPs showed an even larger effect. These findings can contribute to the design of effective marker-assisted selection programs. EEA Rafaela Fil: Nani, Juan Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina Fil: Raschia, Maria Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina Fil: Carignano, Hugo Adrian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina Fil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina Fil: Calvinho, Luis Fernando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina Fil: Amadio, Ariel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2018-07-19T13:01:28Z 2018-07-19T13:01:28Z 2015-11 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://link.springer.com/article/10.1007%2Fs13353-015-0278-5 http://hdl.handle.net/20.500.12123/2823 1234-1983 2190-3883 https://doi.org/10.1007/s13353-015-0278-5 eng info:eu-repo/semantics/restrictedAccess application/pdf Journal of Applied Genetics 56 (4) : 505–513 (November 2015) |
| spellingShingle | Ganado de Leche Control de Enfermedades Enfermedades de los Animales Mastítis Bovina Genes Células Somáticas Dairy Cattle Disease Control Animal Diseases Bovine Mastitis Somatic Cells Argentina Nani, Juan Pablo Raschia, Maria Agustina Carignano, Hugo Poli, Mario Andres Calvinho, Luis Fernando Amadio, Ariel Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattle |
| title | Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattle |
| title_full | Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattle |
| title_fullStr | Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattle |
| title_full_unstemmed | Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattle |
| title_short | Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattle |
| title_sort | single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in argentinean dairy cattle |
| topic | Ganado de Leche Control de Enfermedades Enfermedades de los Animales Mastítis Bovina Genes Células Somáticas Dairy Cattle Disease Control Animal Diseases Bovine Mastitis Somatic Cells Argentina |
| url | https://link.springer.com/article/10.1007%2Fs13353-015-0278-5 http://hdl.handle.net/20.500.12123/2823 https://doi.org/10.1007/s13353-015-0278-5 |
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