Characterization of immune response in Staphylococcus aureus chronically infected bovine mammary glands during active involution
The aim of this study was to characterize the immune response in Staphylococcus aureus chronically infected bovine mammary glands during active involution. Twenty-one Holstein non-pregnant cows in late lactation either uninfected or with chronic naturally acquired S. aureus intramammary infections (...
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
2018
|
| Materias: | |
| Acceso en línea: | https://www.sciencedirect.com/science/article/pii/S0147957117300759 http://hdl.handle.net/20.500.12123/2776 https://doi.org/10.1016/j.cimid.2017.08.005 |
| _version_ | 1855483118154153984 |
|---|---|
| author | Andreotti, Carolina Soledad Baravalle, Celina Sacco, Sofía Clara Lovato, Melisa Belen Pereyra, Elizabet Amanda Lorena Renna, María Sol Ortega, Hugo Hector Calvinho, Luis Fernando Dallard, Bibiana Elisabet |
| author_browse | Andreotti, Carolina Soledad Baravalle, Celina Calvinho, Luis Fernando Dallard, Bibiana Elisabet Lovato, Melisa Belen Ortega, Hugo Hector Pereyra, Elizabet Amanda Lorena Renna, María Sol Sacco, Sofía Clara |
| author_facet | Andreotti, Carolina Soledad Baravalle, Celina Sacco, Sofía Clara Lovato, Melisa Belen Pereyra, Elizabet Amanda Lorena Renna, María Sol Ortega, Hugo Hector Calvinho, Luis Fernando Dallard, Bibiana Elisabet |
| author_sort | Andreotti, Carolina Soledad |
| collection | INTA Digital |
| description | The aim of this study was to characterize the immune response in Staphylococcus aureus chronically infected bovine mammary glands during active involution. Twenty-one Holstein non-pregnant cows in late lactation either uninfected or with chronic naturally acquired S. aureus intramammary infections (IMI) were included in this study. Cows were slaughtered at 7, 14 and 21 d after cessation of milking and samples for immunohistochemical analysis were taken. Protein expression of toll-like receptor 2 (TLR2) and TLR4 was significantly higher in S. aureus-infected quarters than in uninfected controls at the three involution stages studied. Protein expression of tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1α and IL-17 was significantly affected by IMI; being higher in S. aureus-infected than uninfected quarters during all evaluated stages. In S. aureus-infected and uninfected quarters protein expression of lactoferrin increased from day 7–14 of involution, decreasing significantly to day 21 in mammary quarters with chronic infections. The number of monocytes-macrophages was significantly higher in S. aureus-infected than in uninfected control quarters at 7 and 21 d of involution. The number of T lymphocytes was significantly higher in S. aureus-infected than in uninfected quarters at 7 and 14 d of involution while the number of B lymphocytes was significantly higher in S. aureus-infected than in uninfected quarters during all evaluated stages, showing a progressive increase as involution advanced. These results demonstrated a sustained and exacerbated innate and adaptive immune response during chronic S. aureus IMI, playing a critical role in the infection control during active involution. |
| format | Artículo |
| id | INTA2776 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| record_format | dspace |
| spelling | INTA27762018-07-12T14:28:31Z Characterization of immune response in Staphylococcus aureus chronically infected bovine mammary glands during active involution Andreotti, Carolina Soledad Baravalle, Celina Sacco, Sofía Clara Lovato, Melisa Belen Pereyra, Elizabet Amanda Lorena Renna, María Sol Ortega, Hugo Hector Calvinho, Luis Fernando Dallard, Bibiana Elisabet Staphylococcus aureus Ganado Bovino Respuesta Inmunológica Glándulas Mamarias Infección Mastítis Bovina Cattle Immune Response Mammary Glands Infection Bovine Mastitis The aim of this study was to characterize the immune response in Staphylococcus aureus chronically infected bovine mammary glands during active involution. Twenty-one Holstein non-pregnant cows in late lactation either uninfected or with chronic naturally acquired S. aureus intramammary infections (IMI) were included in this study. Cows were slaughtered at 7, 14 and 21 d after cessation of milking and samples for immunohistochemical analysis were taken. Protein expression of toll-like receptor 2 (TLR2) and TLR4 was significantly higher in S. aureus-infected quarters than in uninfected controls at the three involution stages studied. Protein expression of tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1α and IL-17 was significantly affected by IMI; being higher in S. aureus-infected than uninfected quarters during all evaluated stages. In S. aureus-infected and uninfected quarters protein expression of lactoferrin increased from day 7–14 of involution, decreasing significantly to day 21 in mammary quarters with chronic infections. The number of monocytes-macrophages was significantly higher in S. aureus-infected than in uninfected control quarters at 7 and 21 d of involution. The number of T lymphocytes was significantly higher in S. aureus-infected than in uninfected quarters at 7 and 14 d of involution while the number of B lymphocytes was significantly higher in S. aureus-infected than in uninfected quarters during all evaluated stages, showing a progressive increase as involution advanced. These results demonstrated a sustained and exacerbated innate and adaptive immune response during chronic S. aureus IMI, playing a critical role in the infection control during active involution. EEA Rafaela Fil: Andreotti, Carolina Soledad. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Laboratorio de Biología Celular y Molecular Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológica; Argentina Fil: Baravalle, Celina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Laboratorio de Biología Celular y Molecular Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas; Argentina Fil: Sacco, Sofía Clara. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Laboratorio de Biología Celular y Molecular Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas; Argentina Fil: Lovato, Melisa Belen. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Laboratorio de Biología Celular y Molecular Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina Fil: Pereyra, Elizabet Amanda Lorena. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Laboratorio de Biología Celular y Molecular Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas; Argentina Fil: Renna, María Sol. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Laboratorio de Biología Celular y Molecular Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina Fil: Ortega, Hugo Hector. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Laboratorio de Biología Celular y Molecular Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas; Argentina Fil: Calvinho, Luis Fernando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Clínicas; Argentina Fil: Dallard, Bibiana Elisabet. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Laboratorio de Biología Celular y Molecular Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas; Argentina 2018-07-12T14:26:58Z 2018-07-12T14:26:58Z 2017-10 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.sciencedirect.com/science/article/pii/S0147957117300759 http://hdl.handle.net/20.500.12123/2776 0147-9571 https://doi.org/10.1016/j.cimid.2017.08.005 eng info:eu-repo/semantics/restrictedAccess application/pdf Comparative Immunology, Microbiology and Infectious Diseases 54 : 51-60 (October 2017) |
| spellingShingle | Staphylococcus aureus Ganado Bovino Respuesta Inmunológica Glándulas Mamarias Infección Mastítis Bovina Cattle Immune Response Mammary Glands Infection Bovine Mastitis Andreotti, Carolina Soledad Baravalle, Celina Sacco, Sofía Clara Lovato, Melisa Belen Pereyra, Elizabet Amanda Lorena Renna, María Sol Ortega, Hugo Hector Calvinho, Luis Fernando Dallard, Bibiana Elisabet Characterization of immune response in Staphylococcus aureus chronically infected bovine mammary glands during active involution |
| title | Characterization of immune response in Staphylococcus aureus chronically infected bovine mammary glands during active involution |
| title_full | Characterization of immune response in Staphylococcus aureus chronically infected bovine mammary glands during active involution |
| title_fullStr | Characterization of immune response in Staphylococcus aureus chronically infected bovine mammary glands during active involution |
| title_full_unstemmed | Characterization of immune response in Staphylococcus aureus chronically infected bovine mammary glands during active involution |
| title_short | Characterization of immune response in Staphylococcus aureus chronically infected bovine mammary glands during active involution |
| title_sort | characterization of immune response in staphylococcus aureus chronically infected bovine mammary glands during active involution |
| topic | Staphylococcus aureus Ganado Bovino Respuesta Inmunológica Glándulas Mamarias Infección Mastítis Bovina Cattle Immune Response Mammary Glands Infection Bovine Mastitis |
| url | https://www.sciencedirect.com/science/article/pii/S0147957117300759 http://hdl.handle.net/20.500.12123/2776 https://doi.org/10.1016/j.cimid.2017.08.005 |
| work_keys_str_mv | AT andreotticarolinasoledad characterizationofimmuneresponseinstaphylococcusaureuschronicallyinfectedbovinemammaryglandsduringactiveinvolution AT baravallecelina characterizationofimmuneresponseinstaphylococcusaureuschronicallyinfectedbovinemammaryglandsduringactiveinvolution AT saccosofiaclara characterizationofimmuneresponseinstaphylococcusaureuschronicallyinfectedbovinemammaryglandsduringactiveinvolution AT lovatomelisabelen characterizationofimmuneresponseinstaphylococcusaureuschronicallyinfectedbovinemammaryglandsduringactiveinvolution AT pereyraelizabetamandalorena characterizationofimmuneresponseinstaphylococcusaureuschronicallyinfectedbovinemammaryglandsduringactiveinvolution AT rennamariasol characterizationofimmuneresponseinstaphylococcusaureuschronicallyinfectedbovinemammaryglandsduringactiveinvolution AT ortegahugohector characterizationofimmuneresponseinstaphylococcusaureuschronicallyinfectedbovinemammaryglandsduringactiveinvolution AT calvinholuisfernando characterizationofimmuneresponseinstaphylococcusaureuschronicallyinfectedbovinemammaryglandsduringactiveinvolution AT dallardbibianaelisabet characterizationofimmuneresponseinstaphylococcusaureuschronicallyinfectedbovinemammaryglandsduringactiveinvolution |