Intramammary inoculation of Panax ginseng plays an immunoprotective role in Staphylococcus aureus infection in a murine model

The immunoprotective effect of Panax ginseng (Pg) extract was investigated in a mouse mastitis model. Lactating female mice were intramammarily inoculated with Pg or placebo, and then were challenged with S. aureus, while other group was inoculated with S. aureus alone. The number of bacteria recove...

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Main Authors: Silvestrini, Paula, Beccaria, Camila, Pereyra, Elizabet Amanda Lorena, Renna, María Sol, Ortega, Hugo Hector, Calvinho, Luis Fernando, Dallard, Bibiana Elisabet, Baravalle, Celina
Format: Artículo
Language:Inglés
Published: 2018
Subjects:
Online Access:https://www.sciencedirect.com/science/article/pii/S003452881730509X
http://hdl.handle.net/20.500.12123/2775
https://doi.org/10.1016/j.rvsc.2017.05.010
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author Silvestrini, Paula
Beccaria, Camila
Pereyra, Elizabet Amanda Lorena
Renna, María Sol
Ortega, Hugo Hector
Calvinho, Luis Fernando
Dallard, Bibiana Elisabet
Baravalle, Celina
author_browse Baravalle, Celina
Beccaria, Camila
Calvinho, Luis Fernando
Dallard, Bibiana Elisabet
Ortega, Hugo Hector
Pereyra, Elizabet Amanda Lorena
Renna, María Sol
Silvestrini, Paula
author_facet Silvestrini, Paula
Beccaria, Camila
Pereyra, Elizabet Amanda Lorena
Renna, María Sol
Ortega, Hugo Hector
Calvinho, Luis Fernando
Dallard, Bibiana Elisabet
Baravalle, Celina
author_sort Silvestrini, Paula
collection INTA Digital
description The immunoprotective effect of Panax ginseng (Pg) extract was investigated in a mouse mastitis model. Lactating female mice were intramammarily inoculated with Pg or placebo, and then were challenged with S. aureus, while other group was inoculated with S. aureus alone. The number of bacteria recovered from mammary glands was significantly lower in Pg-treated S. aureus-infected mice (group I) compared with placebo-treated S. aureus-infected mice (group II) and S. aureus-infected mice (group III). The mRNA expression of TLR2, TLR4, IL-1α and TNF-α was influenced by treatment; being the transcript levels for all genes higher in group I compared with group II and III. Activation of NF-κB and the number of monocytes-macrophages in mammary gland tissue was significantly increased in group I compared with group II and III. Pg extract was able to trigger an adequate immune response to confront an infection demonstrating its protective effect and potential for preventing bovine intramammary infections.
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spelling INTA27752018-07-12T14:18:15Z Intramammary inoculation of Panax ginseng plays an immunoprotective role in Staphylococcus aureus infection in a murine model Silvestrini, Paula Beccaria, Camila Pereyra, Elizabet Amanda Lorena Renna, María Sol Ortega, Hugo Hector Calvinho, Luis Fernando Dallard, Bibiana Elisabet Baravalle, Celina Panax pseudoginseng Staphylococcus aureus Respuesta Inmunológica Murinae Rodentia Mastitis Ratón Immune Response Mice Panax ginseng The immunoprotective effect of Panax ginseng (Pg) extract was investigated in a mouse mastitis model. Lactating female mice were intramammarily inoculated with Pg or placebo, and then were challenged with S. aureus, while other group was inoculated with S. aureus alone. The number of bacteria recovered from mammary glands was significantly lower in Pg-treated S. aureus-infected mice (group I) compared with placebo-treated S. aureus-infected mice (group II) and S. aureus-infected mice (group III). The mRNA expression of TLR2, TLR4, IL-1α and TNF-α was influenced by treatment; being the transcript levels for all genes higher in group I compared with group II and III. Activation of NF-κB and the number of monocytes-macrophages in mammary gland tissue was significantly increased in group I compared with group II and III. Pg extract was able to trigger an adequate immune response to confront an infection demonstrating its protective effect and potential for preventing bovine intramammary infections. EEA Rafaela Fil: Silvestrini, Paula. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Laboratorio de Biología Celular y Molecular Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina Fil: Beccaría, Camila. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Laboratorio de Biología Celular y Molecular Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Clínicas; Argentina Fil: Pereyra, Elizabet Amanda Lorena. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Laboratorio de Biología Celular y Molecular Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas; Argentina Fil: Renna, María Sol. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Laboratorio de Biología Celular y Molecular Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina Fil: Ortega, Hugo Hector. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Laboratorio de Biología Celular y Molecular Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas; Argentina Fil: Calvinho, Luis Fernando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Clínicas; Argentina Fil: Dallard, Bibiana Elisabet. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Laboratorio de Biología Celular y Molecular Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas; Argentina Fil: Baravalle, Celina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Laboratorio de Biología Celular y Molecular Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas; Argentina 2018-07-12T13:00:11Z 2018-07-12T13:00:11Z 2017-12 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.sciencedirect.com/science/article/pii/S003452881730509X http://hdl.handle.net/20.500.12123/2775 0034-5288 1532-2661 https://doi.org/10.1016/j.rvsc.2017.05.010 eng info:eu-repo/semantics/restrictedAccess application/pdf Research in Veterinary Science 115 : 211-220 (December 2017)
spellingShingle Panax pseudoginseng
Staphylococcus aureus
Respuesta Inmunológica
Murinae
Rodentia
Mastitis
Ratón
Immune Response
Mice
Panax ginseng
Silvestrini, Paula
Beccaria, Camila
Pereyra, Elizabet Amanda Lorena
Renna, María Sol
Ortega, Hugo Hector
Calvinho, Luis Fernando
Dallard, Bibiana Elisabet
Baravalle, Celina
Intramammary inoculation of Panax ginseng plays an immunoprotective role in Staphylococcus aureus infection in a murine model
title Intramammary inoculation of Panax ginseng plays an immunoprotective role in Staphylococcus aureus infection in a murine model
title_full Intramammary inoculation of Panax ginseng plays an immunoprotective role in Staphylococcus aureus infection in a murine model
title_fullStr Intramammary inoculation of Panax ginseng plays an immunoprotective role in Staphylococcus aureus infection in a murine model
title_full_unstemmed Intramammary inoculation of Panax ginseng plays an immunoprotective role in Staphylococcus aureus infection in a murine model
title_short Intramammary inoculation of Panax ginseng plays an immunoprotective role in Staphylococcus aureus infection in a murine model
title_sort intramammary inoculation of panax ginseng plays an immunoprotective role in staphylococcus aureus infection in a murine model
topic Panax pseudoginseng
Staphylococcus aureus
Respuesta Inmunológica
Murinae
Rodentia
Mastitis
Ratón
Immune Response
Mice
Panax ginseng
url https://www.sciencedirect.com/science/article/pii/S003452881730509X
http://hdl.handle.net/20.500.12123/2775
https://doi.org/10.1016/j.rvsc.2017.05.010
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