Nanocomposites based on pH-sensitive hydrogels and chitosan decorated carbon nanotubes with antibacterial properties
The present work aimed to study the properties of a novel nanocomposite with promising biomedical applications. Nanocomposites were prepared by the addition of different concentrations of chitosan decorated carbon nanotubes to acrylamide-co-acrylic acid hydrogels. The nanocomposites chemical structu...
| Autores principales: | , , , , , , , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.sciencedirect.com/science/article/pii/S0928493117335361?via%3Dihub http://hdl.handle.net/20.500.12123/2755 https://doi.org/10.1016/j.msec.2018.04.090 |
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| author | Bellingeri, Romina Mulko, Lucinda Molina, Maria Picco, Natalia Alustiza, Fabrisio Eduardo Grosso, M. Carolina Vivas, Adriana Acevedo, Diego F. Barbero, Cesar A. |
| author_browse | Acevedo, Diego F. Alustiza, Fabrisio Eduardo Barbero, Cesar A. Bellingeri, Romina Grosso, M. Carolina Molina, Maria Mulko, Lucinda Picco, Natalia Vivas, Adriana |
| author_facet | Bellingeri, Romina Mulko, Lucinda Molina, Maria Picco, Natalia Alustiza, Fabrisio Eduardo Grosso, M. Carolina Vivas, Adriana Acevedo, Diego F. Barbero, Cesar A. |
| author_sort | Bellingeri, Romina |
| collection | INTA Digital |
| description | The present work aimed to study the properties of a novel nanocomposite with promising biomedical applications. Nanocomposites were prepared by the addition of different concentrations of chitosan decorated carbon nanotubes to acrylamide-co-acrylic acid hydrogels. The nanocomposites chemical structure was characterized by Fourier Transform Infrared Spectroscopy (FT-IR). The FT-IR shows the typical bands due to the hydrogel and additionally the peaks at 1750 cm−1 and 1450 cm−1 that correspond to the carbon nanotubes incorporated into the polymer matrix. Mechanical properties and swelling measurements in different buffer solutions were also performed. The nanocomposites showed improved mechanical properties and a stronger pH-response. In order to evaluate antimicrobial activity, the growth and adhesion of Staphylococcus aureus to nanocomposites were studied. Cytocompatibility was also evaluated by MTT assay on MDCK and 3T3 cell lines. The nanocomposites were found to be cytocompatible and showed a reduced bacterial colonization. |
| format | info:ar-repo/semantics/artículo |
| id | INTA2755 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| record_format | dspace |
| spelling | INTA27552018-07-27T14:40:37Z Nanocomposites based on pH-sensitive hydrogels and chitosan decorated carbon nanotubes with antibacterial properties Bellingeri, Romina Mulko, Lucinda Molina, Maria Picco, Natalia Alustiza, Fabrisio Eduardo Grosso, M. Carolina Vivas, Adriana Acevedo, Diego F. Barbero, Cesar A. Quitosano Geles Nanocompuestos pH Propiedades Antimicrobianas Chitosan Gels Nanocomposites Antimicrobial Properties Hidrogeles Propiedades Antibacterianas Biomateriales The present work aimed to study the properties of a novel nanocomposite with promising biomedical applications. Nanocomposites were prepared by the addition of different concentrations of chitosan decorated carbon nanotubes to acrylamide-co-acrylic acid hydrogels. The nanocomposites chemical structure was characterized by Fourier Transform Infrared Spectroscopy (FT-IR). The FT-IR shows the typical bands due to the hydrogel and additionally the peaks at 1750 cm−1 and 1450 cm−1 that correspond to the carbon nanotubes incorporated into the polymer matrix. Mechanical properties and swelling measurements in different buffer solutions were also performed. The nanocomposites showed improved mechanical properties and a stronger pH-response. In order to evaluate antimicrobial activity, the growth and adhesion of Staphylococcus aureus to nanocomposites were studied. Cytocompatibility was also evaluated by MTT assay on MDCK and 3T3 cell lines. The nanocomposites were found to be cytocompatible and showed a reduced bacterial colonization. EEA Marcos Juárez Fil: Bellingeri, Romina. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Anatomía Animal. Laboratorio de Biotecnología Animal; Argentina Fil: Mulko, Lucinda. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Físico-Químicas y Naturales. Departamento de Química. Laboratorio de Materiales Avanzados; Argentina Fil: Molina, Maria. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Físico-Químicas y Naturales. Departamento de Química. Laboratorio de Materiales Avanzados; Argentina Fil: Picco, Natalia. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Anatomía Animal. Laboratorio de Biotecnología Animal; Argentina Fil: Alustiza, Fabrisio Eduardo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Marcos Juárez; Argentina Fil: Grosso, M. Carolina. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Anatomía Animal. Laboratorio de Biotecnología Animal; Argentina Fil: Vivas, Adriana. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Anatomía Animal. Laboratorio de Biotecnología Animal; Argentina Fil: Acevedo, Diego F. Universidad Nacional de Río Cuarto. Facultad de Ingeniería. Departamento de Tecnología Química; Argentina Fil: Barbero, Cesar A.. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Físico-Químicas y Naturales. Departamento de Química. Laboratorio de Materiales Avanzados; Argentina 2018-07-10T16:52:02Z 2018-07-10T16:52:02Z 2018-09-01 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.sciencedirect.com/science/article/pii/S0928493117335361?via%3Dihub http://hdl.handle.net/20.500.12123/2755 0928-4931 https://doi.org/10.1016/j.msec.2018.04.090 eng info:eu-repo/semantics/restrictedAccess application/pdf Materials Science and Engineering: C 90 : 461-467 (September 2018) |
| spellingShingle | Quitosano Geles Nanocompuestos pH Propiedades Antimicrobianas Chitosan Gels Nanocomposites Antimicrobial Properties Hidrogeles Propiedades Antibacterianas Biomateriales Bellingeri, Romina Mulko, Lucinda Molina, Maria Picco, Natalia Alustiza, Fabrisio Eduardo Grosso, M. Carolina Vivas, Adriana Acevedo, Diego F. Barbero, Cesar A. Nanocomposites based on pH-sensitive hydrogels and chitosan decorated carbon nanotubes with antibacterial properties |
| title | Nanocomposites based on pH-sensitive hydrogels and chitosan decorated carbon nanotubes with antibacterial properties |
| title_full | Nanocomposites based on pH-sensitive hydrogels and chitosan decorated carbon nanotubes with antibacterial properties |
| title_fullStr | Nanocomposites based on pH-sensitive hydrogels and chitosan decorated carbon nanotubes with antibacterial properties |
| title_full_unstemmed | Nanocomposites based on pH-sensitive hydrogels and chitosan decorated carbon nanotubes with antibacterial properties |
| title_short | Nanocomposites based on pH-sensitive hydrogels and chitosan decorated carbon nanotubes with antibacterial properties |
| title_sort | nanocomposites based on ph sensitive hydrogels and chitosan decorated carbon nanotubes with antibacterial properties |
| topic | Quitosano Geles Nanocompuestos pH Propiedades Antimicrobianas Chitosan Gels Nanocomposites Antimicrobial Properties Hidrogeles Propiedades Antibacterianas Biomateriales |
| url | https://www.sciencedirect.com/science/article/pii/S0928493117335361?via%3Dihub http://hdl.handle.net/20.500.12123/2755 https://doi.org/10.1016/j.msec.2018.04.090 |
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