Systemic antibodies administered by passive immunization prevent generalization of the infection by foot-and-mouth disease virus in cattle after oronasal challenge
The role of passively transferred sera in the protection against aerogenous foot-and-mouth disease (FMD) virus infection in cattle was evaluated using vaccine-induced immune serum preparations obtained at 7 and 26 days post-vaccination (dpv). We showed that circulating antibodies were sufficient to...
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| Format: | Artículo |
| Language: | Inglés |
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2018
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| Online Access: | https://www.sciencedirect.com/science/article/pii/S0042682218300552 http://hdl.handle.net/20.500.12123/2540 https://doi.org/10.1016/j.virol.2018.02.012 |
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| author | Barrionuevo, Florencia Mariel Di Giacomo, Sebastián Bucafusco, Danilo Ayude, Andrea Fabiana Schammas, Juan Manuel Miraglia, María Cruz Capozzo, Alejandra Victoria Borca, Manuel Victor Perez Filgueira, Daniel Mariano |
| author_browse | Ayude, Andrea Fabiana Barrionuevo, Florencia Mariel Borca, Manuel Victor Bucafusco, Danilo Capozzo, Alejandra Victoria Di Giacomo, Sebastián Miraglia, María Cruz Perez Filgueira, Daniel Mariano Schammas, Juan Manuel |
| author_facet | Barrionuevo, Florencia Mariel Di Giacomo, Sebastián Bucafusco, Danilo Ayude, Andrea Fabiana Schammas, Juan Manuel Miraglia, María Cruz Capozzo, Alejandra Victoria Borca, Manuel Victor Perez Filgueira, Daniel Mariano |
| author_sort | Barrionuevo, Florencia Mariel |
| collection | INTA Digital |
| description | The role of passively transferred sera in the protection against aerogenous foot-and-mouth disease (FMD) virus infection in cattle was evaluated using vaccine-induced immune serum preparations obtained at 7 and 26 days post-vaccination (dpv). We showed that circulating antibodies were sufficient to prevent disease generalization after oronasal infection in animals passively transferred with 26-dpv serum but not with the 7-dpv serum. Conversely, conventional FMD vaccination provided clinical protection at 7 dpv, promoting fast and robust antibody responses upon challenge and even though antibody titers were similar to those found in animals passively immunized with 7-dpv serum. These results demonstrate that presence of antigen-specific antibodies is critical to prevent the dissemination of the virus within the animal. Conventional FMD vaccination additionally promoted the deployment of rapid, high titer and isotype-switched antibody responses at systemic and mucosal levels after infection, thus conferring protection even in the presence of low pre-challenge antibody titers. |
| format | Artículo |
| id | INTA2540 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| record_format | dspace |
| spelling | INTA25402018-06-28T12:46:59Z Systemic antibodies administered by passive immunization prevent generalization of the infection by foot-and-mouth disease virus in cattle after oronasal challenge Barrionuevo, Florencia Mariel Di Giacomo, Sebastián Bucafusco, Danilo Ayude, Andrea Fabiana Schammas, Juan Manuel Miraglia, María Cruz Capozzo, Alejandra Victoria Borca, Manuel Victor Perez Filgueira, Daniel Mariano Ganado Bovino Enfermedades de los Animales Fiebre Aftosa Anticuerpos Inmunidad Pasiva Cattle Animal Diseases Foot and Mouth Disease Antibodies Passive Immunity The role of passively transferred sera in the protection against aerogenous foot-and-mouth disease (FMD) virus infection in cattle was evaluated using vaccine-induced immune serum preparations obtained at 7 and 26 days post-vaccination (dpv). We showed that circulating antibodies were sufficient to prevent disease generalization after oronasal infection in animals passively transferred with 26-dpv serum but not with the 7-dpv serum. Conversely, conventional FMD vaccination provided clinical protection at 7 dpv, promoting fast and robust antibody responses upon challenge and even though antibody titers were similar to those found in animals passively immunized with 7-dpv serum. These results demonstrate that presence of antigen-specific antibodies is critical to prevent the dissemination of the virus within the animal. Conventional FMD vaccination additionally promoted the deployment of rapid, high titer and isotype-switched antibody responses at systemic and mucosal levels after infection, thus conferring protection even in the presence of low pre-challenge antibody titers. Instituto de Virología Fil: Barrionuevo, Florencia Mariel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Di Giacomo, Sebastián. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Bucafusco, Danilo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Ayude, Andrea Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Schammas, Juan Manuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Miraglia, María Cruz. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Capozzo, Alejandra Victoria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Borca, Manuel Victor. USDA. Agricultural Research Service. Plum Island Animal Disease Center; Estados Unidos Fil: Perez Filgueira, Daniel Mariano. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2018-06-04T13:59:45Z 2018-06-04T13:59:45Z 2018-05 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.sciencedirect.com/science/article/pii/S0042682218300552 http://hdl.handle.net/20.500.12123/2540 0042-6822 https://doi.org/10.1016/j.virol.2018.02.012 eng info:eu-repo/semantics/restrictedAccess application/pdf Virology 518 : 143-151. (May 2018) |
| spellingShingle | Ganado Bovino Enfermedades de los Animales Fiebre Aftosa Anticuerpos Inmunidad Pasiva Cattle Animal Diseases Foot and Mouth Disease Antibodies Passive Immunity Barrionuevo, Florencia Mariel Di Giacomo, Sebastián Bucafusco, Danilo Ayude, Andrea Fabiana Schammas, Juan Manuel Miraglia, María Cruz Capozzo, Alejandra Victoria Borca, Manuel Victor Perez Filgueira, Daniel Mariano Systemic antibodies administered by passive immunization prevent generalization of the infection by foot-and-mouth disease virus in cattle after oronasal challenge |
| title | Systemic antibodies administered by passive immunization prevent generalization of the infection by foot-and-mouth disease virus in cattle after oronasal challenge |
| title_full | Systemic antibodies administered by passive immunization prevent generalization of the infection by foot-and-mouth disease virus in cattle after oronasal challenge |
| title_fullStr | Systemic antibodies administered by passive immunization prevent generalization of the infection by foot-and-mouth disease virus in cattle after oronasal challenge |
| title_full_unstemmed | Systemic antibodies administered by passive immunization prevent generalization of the infection by foot-and-mouth disease virus in cattle after oronasal challenge |
| title_short | Systemic antibodies administered by passive immunization prevent generalization of the infection by foot-and-mouth disease virus in cattle after oronasal challenge |
| title_sort | systemic antibodies administered by passive immunization prevent generalization of the infection by foot and mouth disease virus in cattle after oronasal challenge |
| topic | Ganado Bovino Enfermedades de los Animales Fiebre Aftosa Anticuerpos Inmunidad Pasiva Cattle Animal Diseases Foot and Mouth Disease Antibodies Passive Immunity |
| url | https://www.sciencedirect.com/science/article/pii/S0042682218300552 http://hdl.handle.net/20.500.12123/2540 https://doi.org/10.1016/j.virol.2018.02.012 |
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