Exploring the association between polymorphisms at 3’UTR SLC11A1 gene microsatellites and resistance to tuberculosis: A case-control study in Bos taurus dairy cattle
Bovine tuberculosis is a contagious infectious disease that causes significant economic impact in dairy and meat farms throughout the world. Multiple factors, including host genome, determine the outcome of the infection. Several studies have associated polymorphisms at the two microsatellites (Ms)...
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| Format: | Artículo |
| Language: | Inglés |
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2018
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| Online Access: | https://www.sciencedirect.com/science/article/pii/S1871141318300192 http://hdl.handle.net/20.500.12123/2539 https://doi.org/10.1016/j.livsci.2018.01.012 |
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| author | Hasenauer, Flavia Carolina Garbaccio, Sergio Gabriel Caffaro, María Eugenia Garro, Carlos Javier Huertas, Pablo Sebastian Poli, Mario Andres Rossetti, Carlos Alberto |
| author_browse | Caffaro, María Eugenia Garbaccio, Sergio Gabriel Garro, Carlos Javier Hasenauer, Flavia Carolina Huertas, Pablo Sebastian Poli, Mario Andres Rossetti, Carlos Alberto |
| author_facet | Hasenauer, Flavia Carolina Garbaccio, Sergio Gabriel Caffaro, María Eugenia Garro, Carlos Javier Huertas, Pablo Sebastian Poli, Mario Andres Rossetti, Carlos Alberto |
| author_sort | Hasenauer, Flavia Carolina |
| collection | INTA Digital |
| description | Bovine tuberculosis is a contagious infectious disease that causes significant economic impact in dairy and meat farms throughout the world. Multiple factors, including host genome, determine the outcome of the infection. Several studies have associated polymorphisms at the two microsatellites (Ms) -Ms1 and Ms2- at the 3´unstranslated (UTR) region of the SLC11A1 bovine gene with innate resistance or susceptibility to some facultative intracellular bacterial infections, such as Brucella abortus and Mycobacterium avium subsp. paratuberculosis. Today, the few studies that investigated the association of those polymorphisms with innate resistance or susceptibility to tuberculosis in cattle, have shown opposite results. The aim of this study was to evaluate the role, if any, of the Ms1 and/or Ms2 polymorphisms at the 3´UTR of the SLC11A1 gene in Mycobacterium bovis infection phenotypes in Bos taurus dairy cattle. Jersey (n = 149) and Holstein (n = 427) cattle under risk of natural M. bovis infection were classified like controls (n = 326) and cases (n = 250) based on the response to caudal fold tuberculin skin test. Cattle population was genotyped by capillary electrophoresis based on polymorphisms in Ms1 and Ms2 at the 3´UTR SLC11A1 gene. The results presented here showed a lack of association (p > .05) between polymorphisms at the 3´UTR SLC11A1 gene and the response to tuberculin skin test in dairy Bos taurus cattle. Further studies are necessary to establish robustly genes or genome regions determining the innate R/S phenotype to Mycobacterium bovis. |
| format | Artículo |
| id | INTA2539 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| record_format | dspace |
| spelling | INTA25392018-06-29T17:28:31Z Exploring the association between polymorphisms at 3’UTR SLC11A1 gene microsatellites and resistance to tuberculosis: A case-control study in Bos taurus dairy cattle Hasenauer, Flavia Carolina Garbaccio, Sergio Gabriel Caffaro, María Eugenia Garro, Carlos Javier Huertas, Pablo Sebastian Poli, Mario Andres Rossetti, Carlos Alberto Ganado de Leche Enfermedades de los Animales Microsatélites Bos Taurus Resistencia a la Enfermedad Tuberculosis Dairy Cattle Animal Diseases Microsatellites Disease Resistance Bovine tuberculosis is a contagious infectious disease that causes significant economic impact in dairy and meat farms throughout the world. Multiple factors, including host genome, determine the outcome of the infection. Several studies have associated polymorphisms at the two microsatellites (Ms) -Ms1 and Ms2- at the 3´unstranslated (UTR) region of the SLC11A1 bovine gene with innate resistance or susceptibility to some facultative intracellular bacterial infections, such as Brucella abortus and Mycobacterium avium subsp. paratuberculosis. Today, the few studies that investigated the association of those polymorphisms with innate resistance or susceptibility to tuberculosis in cattle, have shown opposite results. The aim of this study was to evaluate the role, if any, of the Ms1 and/or Ms2 polymorphisms at the 3´UTR of the SLC11A1 gene in Mycobacterium bovis infection phenotypes in Bos taurus dairy cattle. Jersey (n = 149) and Holstein (n = 427) cattle under risk of natural M. bovis infection were classified like controls (n = 326) and cases (n = 250) based on the response to caudal fold tuberculin skin test. Cattle population was genotyped by capillary electrophoresis based on polymorphisms in Ms1 and Ms2 at the 3´UTR SLC11A1 gene. The results presented here showed a lack of association (p > .05) between polymorphisms at the 3´UTR SLC11A1 gene and the response to tuberculin skin test in dairy Bos taurus cattle. Further studies are necessary to establish robustly genes or genome regions determining the innate R/S phenotype to Mycobacterium bovis. Instituto de Patobiología Fil: Hasenauer, Flavia Carolina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Garbaccio, Sergio Gabriel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina Fil: Caffaro, María Eugenia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina Fil: Garro, Carlos Javier. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina Fil: Huertas, Pablo Sebastian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina Fil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina Fil: Rossetti, Carlos Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina 2018-06-04T13:38:52Z 2018-06-04T13:38:52Z 2018-04 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.sciencedirect.com/science/article/pii/S1871141318300192 http://hdl.handle.net/20.500.12123/2539 1871-1413 https://doi.org/10.1016/j.livsci.2018.01.012 eng info:eu-repo/semantics/restrictedAccess application/pdf Livestock science 210 : 1-7. (April 2018) |
| spellingShingle | Ganado de Leche Enfermedades de los Animales Microsatélites Bos Taurus Resistencia a la Enfermedad Tuberculosis Dairy Cattle Animal Diseases Microsatellites Disease Resistance Hasenauer, Flavia Carolina Garbaccio, Sergio Gabriel Caffaro, María Eugenia Garro, Carlos Javier Huertas, Pablo Sebastian Poli, Mario Andres Rossetti, Carlos Alberto Exploring the association between polymorphisms at 3’UTR SLC11A1 gene microsatellites and resistance to tuberculosis: A case-control study in Bos taurus dairy cattle |
| title | Exploring the association between polymorphisms at 3’UTR SLC11A1 gene microsatellites and resistance to tuberculosis: A case-control study in Bos taurus dairy cattle |
| title_full | Exploring the association between polymorphisms at 3’UTR SLC11A1 gene microsatellites and resistance to tuberculosis: A case-control study in Bos taurus dairy cattle |
| title_fullStr | Exploring the association between polymorphisms at 3’UTR SLC11A1 gene microsatellites and resistance to tuberculosis: A case-control study in Bos taurus dairy cattle |
| title_full_unstemmed | Exploring the association between polymorphisms at 3’UTR SLC11A1 gene microsatellites and resistance to tuberculosis: A case-control study in Bos taurus dairy cattle |
| title_short | Exploring the association between polymorphisms at 3’UTR SLC11A1 gene microsatellites and resistance to tuberculosis: A case-control study in Bos taurus dairy cattle |
| title_sort | exploring the association between polymorphisms at 3 utr slc11a1 gene microsatellites and resistance to tuberculosis a case control study in bos taurus dairy cattle |
| topic | Ganado de Leche Enfermedades de los Animales Microsatélites Bos Taurus Resistencia a la Enfermedad Tuberculosis Dairy Cattle Animal Diseases Microsatellites Disease Resistance |
| url | https://www.sciencedirect.com/science/article/pii/S1871141318300192 http://hdl.handle.net/20.500.12123/2539 https://doi.org/10.1016/j.livsci.2018.01.012 |
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