Influence of antibodies transferred by colostrum in the immune responses of calves to current foot-and-mouth disease vaccines
Immunity to currently used oil-adjuvanted inactivated vaccines against foot-and-mouth disease virus (FMDV) has been studied in detail in adult animals; however, the influence of maternally derived antibodies transferred through colostrum (Mat-Abs) in the immune responses of vaccinated calves is less...
| Autores principales: | , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
2018
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| Acceso en línea: | https://www.sciencedirect.com/science/article/pii/S0264410X14008573 http://hdl.handle.net/20.500.12123/2515 https://doi.org/10.1016/j.vaccine.2014.06.056 |
| _version_ | 1855483070003544064 |
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| author | Bucafusco, Danilo Di Giacomo, Sebastián Pega, Juan Franco Juncos, María Sol Schammas, Juan Manuel Perez Filgueira, Daniel Mariano Capozzo, Alejandra Victoria |
| author_browse | Bucafusco, Danilo Capozzo, Alejandra Victoria Di Giacomo, Sebastián Juncos, María Sol Pega, Juan Franco Perez Filgueira, Daniel Mariano Schammas, Juan Manuel |
| author_facet | Bucafusco, Danilo Di Giacomo, Sebastián Pega, Juan Franco Juncos, María Sol Schammas, Juan Manuel Perez Filgueira, Daniel Mariano Capozzo, Alejandra Victoria |
| author_sort | Bucafusco, Danilo |
| collection | INTA Digital |
| description | Immunity to currently used oil-adjuvanted inactivated vaccines against foot-and-mouth disease virus (FMDV) has been studied in detail in adult animals; however, the influence of maternally derived antibodies transferred through colostrum (Mat-Abs) in the immune responses of vaccinated calves is less clear. Here, we report the anti-FMDV humoral responses elicited in calves with or without Mat-Abs that received one or two doses of the current tetravalent oil-adjuvanted commercial vaccine used in Argentina. Anti-FMDV (O1/Campos strain) antibodies (Abs) were evaluated by Liquid Phase Blocking ELISA (LPB-ELISA), virus neutralization test (VNT), isotype ELISA (IgG1, IgG2 and IgM) and avidity ELISA, to allow for the first time a more detailed description of the humoral responses elicited. Our results show that primary IgM responses to FMDV vaccination only became evident as Mat-Abs titers decreased. Likewise, prime and boost vaccination schedules, applied 35 days apart to groups of calves with high or low levels of Mat-Abs, showed that the levels of preexisting neutralizing Mat-Abs prevented the loss of total Abs measured by LPB-ELISA but negatively interfered with the induction of virus neutralizing responses. Altogether, these findings indicate that comprehensive serological characterization of immune responses generated after vaccination in calves may reveal important information on the actual effectiveness of vaccination strategies for young animals, particularly in endemic settings. |
| format | Artículo |
| id | INTA2515 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| record_format | dspace |
| spelling | INTA25152018-06-19T18:14:59Z Influence of antibodies transferred by colostrum in the immune responses of calves to current foot-and-mouth disease vaccines Bucafusco, Danilo Di Giacomo, Sebastián Pega, Juan Franco Juncos, María Sol Schammas, Juan Manuel Perez Filgueira, Daniel Mariano Capozzo, Alejandra Victoria Ternero Enfermedades de los Animales Fiebre Aftosa Anticuerpos Calostro Respuesta Inmunológica Vacuna Calves Animal Diseases Foot and Mouth Disease Antibodies Colostrum Immune Response Vaccines Immunity to currently used oil-adjuvanted inactivated vaccines against foot-and-mouth disease virus (FMDV) has been studied in detail in adult animals; however, the influence of maternally derived antibodies transferred through colostrum (Mat-Abs) in the immune responses of vaccinated calves is less clear. Here, we report the anti-FMDV humoral responses elicited in calves with or without Mat-Abs that received one or two doses of the current tetravalent oil-adjuvanted commercial vaccine used in Argentina. Anti-FMDV (O1/Campos strain) antibodies (Abs) were evaluated by Liquid Phase Blocking ELISA (LPB-ELISA), virus neutralization test (VNT), isotype ELISA (IgG1, IgG2 and IgM) and avidity ELISA, to allow for the first time a more detailed description of the humoral responses elicited. Our results show that primary IgM responses to FMDV vaccination only became evident as Mat-Abs titers decreased. Likewise, prime and boost vaccination schedules, applied 35 days apart to groups of calves with high or low levels of Mat-Abs, showed that the levels of preexisting neutralizing Mat-Abs prevented the loss of total Abs measured by LPB-ELISA but negatively interfered with the induction of virus neutralizing responses. Altogether, these findings indicate that comprehensive serological characterization of immune responses generated after vaccination in calves may reveal important information on the actual effectiveness of vaccination strategies for young animals, particularly in endemic settings. Instituto de Virología Fil: Bucafusco, Danilo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Di Giacomo, Sebastián. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Pega, Juan Franco. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Juncos, María Sol. Médica Veterinaria Independiente; Argentina Fil: Schammas, Juan Manuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Perez Filgueira, Daniel Mariano. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Capozzo, Alejandra Victoria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2018-05-30T13:15:25Z 2018-05-30T13:15:25Z 2014-11-12 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.sciencedirect.com/science/article/pii/S0264410X14008573 http://hdl.handle.net/20.500.12123/2515 0264-410X https://doi.org/10.1016/j.vaccine.2014.06.056 eng info:eu-repo/semantics/restrictedAccess application/pdf Vaccine 32 (48) : 6576-6582. (November 2014) |
| spellingShingle | Ternero Enfermedades de los Animales Fiebre Aftosa Anticuerpos Calostro Respuesta Inmunológica Vacuna Calves Animal Diseases Foot and Mouth Disease Antibodies Colostrum Immune Response Vaccines Bucafusco, Danilo Di Giacomo, Sebastián Pega, Juan Franco Juncos, María Sol Schammas, Juan Manuel Perez Filgueira, Daniel Mariano Capozzo, Alejandra Victoria Influence of antibodies transferred by colostrum in the immune responses of calves to current foot-and-mouth disease vaccines |
| title | Influence of antibodies transferred by colostrum in the immune responses of calves to current foot-and-mouth disease vaccines |
| title_full | Influence of antibodies transferred by colostrum in the immune responses of calves to current foot-and-mouth disease vaccines |
| title_fullStr | Influence of antibodies transferred by colostrum in the immune responses of calves to current foot-and-mouth disease vaccines |
| title_full_unstemmed | Influence of antibodies transferred by colostrum in the immune responses of calves to current foot-and-mouth disease vaccines |
| title_short | Influence of antibodies transferred by colostrum in the immune responses of calves to current foot-and-mouth disease vaccines |
| title_sort | influence of antibodies transferred by colostrum in the immune responses of calves to current foot and mouth disease vaccines |
| topic | Ternero Enfermedades de los Animales Fiebre Aftosa Anticuerpos Calostro Respuesta Inmunológica Vacuna Calves Animal Diseases Foot and Mouth Disease Antibodies Colostrum Immune Response Vaccines |
| url | https://www.sciencedirect.com/science/article/pii/S0264410X14008573 http://hdl.handle.net/20.500.12123/2515 https://doi.org/10.1016/j.vaccine.2014.06.056 |
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